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acute coronary syndromes 1

adherence to secondary prevention medications 1

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Developing a new agenda for increased food and climate security

Frontiers of Agricultural Science and Engineering doi: 10.15302/J-FASE-2023514

Abstract:

● The urgent need to address increasing worldwide food and climate insecurity.

Keywords： climate resilience     food security     human health     planetary health     regenerative agriculture    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: Yes-associated protein 1 (YAP1) expression increased in liver tumor cells in early HCC, and AkkermansiaHere, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1knockout (Yap1LKO) maintained bile acid homeostasis in the liver, resulting in an increasedDihydroartemisinin (DHA), acting as YAP1 inhibitor, increased A. muciniphila abundance to sensitizeA. muciniphila by gavage increased the number and activation of CD8+ T cells in liver

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis. Patients were recruited from prospective skin cancer centers and the German national skin cancer registry (ADOReg) of the German Dermatologic Cooperative Oncology Group (DeCOG). Two cohorts were compared: patients with LDT (cohort A, n = 78) versus those without LDT (cohort B, n = 104). Data were analyzed for response to treatment, progression-free survival (PFS), and overall survival (OS). The median OS was significantly longer in cohort A than in cohort B (20.1 vs. 13.8 months; P = 0.0016) and a trend towards improved PFS was observed for cohort A (3.0 vs. 2.5 months; P = 0.054). The objective response rate to any ICB (16.7% vs. 3.8%, P = 0.0073) and combined ICB (14.1% vs. 4.5%, P = 0.017) was more favorable in cohort A. Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM.

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Predication of increased plasma homocysteine level on the prognosis of Chinese patients with first-onset

YAN Jiangtao, SHAO Jiaomei, WANG Daowen, YUE Zhengliang, HUI Rutai

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 352-355 doi: 10.1007/s11684-008-0067-1

Abstract: Epidemiological studies show that increased plasma total homocysteine (tHcy) level was an independentThe increased tHcy level was significantly associated with the risk of death or new vascular events (Increased tHcy level was an independent risk factor for a worse outcome in patients with first-onset
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Cotransfecting norepinephrine transporter and vesicular monoamine transporter 2 genes for increased retention

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 120-128 doi: 10.1007/s11684-017-0501-3

Abstract: Cotransfection of HepG2 cells with NET and VMAT2resulted in increased 

Keywords： norepinephrine transporter     vesicular monoamine transporter 2     -MIBG     gene therapy     lentivirus vector    

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Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 411-415 doi: 10.1007/s11684-012-0226-2

Abstract: pretreatment reinforces the ketamine-elicited antidepressant effects, which is associated with the increased

Keywords： tramadol     ketamine     antidepressant     brain-derived neurotrophic factor     tropomyosin-related kinase B    

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Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

Yang Sun,Chenze Li,Lina Zhang,Dong Hu,Xudong Zhang,Ting Yu,Min Tao,Dao Wen Wang,Xiaoqing Shen

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 53-61 doi: 10.1007/s11684-017-0502-2

Abstract:

Low adherence to secondary prevention medications (ATM) of patients after acute coronary syndrome (ACS) is associated with poor clinical outcomes. However, literature provides limited data on assessment of ATM and risks associated with poor in Chinese patients with ACS. In the current work, ATM was assessed in consecutively recruited patients with ACS in Tongji Hospital from November 5, 2013 to December 31, 2014. A total of 2126 patients were classified under low adherence (proportion of days covered (PDC)<50%) and high adherence (PDC>50%) groups based on their performance after discharge. All patients were followed up at the 1st, 6th, and 12th month of discharge while recording ATM and major adverse cardiac events (MACE). Bivariate logistic regression was used to identify the factors associated with ATM. Cox regression was used to analyze the association between ATM and MACE within one year after discharge. Results showed that coronary artery bypass grafting (CABG) alone had significantly lower proportion of high adherence to P2Y12 antagonists (83.0% vs. 90.7%, P<0.01) than patients treated with percutaneous coronary intervention (PCI) only. Moreover, in patients undergoing PCI, high adherence to P2Y12 antagonists decreased the risk of MACE (hazard ratio=0.172, 95% confidence interval: 0.039–0.763; P=0.021). In conclusion, PCI-treated patients are more prone to remaining adherent to medications than CABG-treated patients. High adherence to P2Y12 antagonists was associated with lower risk of MACE.

Keywords： acute coronary syndromes     adherence to secondary prevention medications     clinical outcome    

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Optimal Su-Do-Ku based interconnection scheme for increased power output from PV array under partial

P. SRINIVASA RAO,P. DINESH,G. SARAVANA ILANGO,C. NAGAMANI

Frontiers in Energy 2015, Volume 9, Issue 2,   Pages 199-210 doi: 10.1007/s11708-015-0350-1

Abstract: Partial shading is a common phenomenon in PV arrays. They drastically reduce the power output because of mismatch losses, which are reliant on the shape of the shade as well as the locations of shaded panels in the array. The power output can be improved by distributing the shade over various rows to maximize the current entering the node. A Su-Do-Ku configuration can be used to rearrange the physical locations of the PV modules in a total cross tied PV array with the electrical connections left unchanged. However, this arrangement increases the length of the wire required to interconnect the panels thus increasing the line losses. In this paper, an improved Su-Do-Ku arrangement that reduces the length of the wire required for the connection is proposed. The system is designed and simulated in a Matlab/Simulink environment for various shading patterns and the efficacies of various arrangements are compared. The results prove that the power output is higher in the proposed improved Su-Do-Ku reconfiguration technique compared to the earlier proposed Su-Do-Ku technique.

Keywords： array configuration     mismatch losses     partial shading     line losses     Su-Do-Ku arrangement    

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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 723-735 doi: 10.1007/s11684-021-0905-y

Abstract: CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALSCORO1A overexpression resulted in increased apoptosis and oxidative stress, overactivated autophagy,

Keywords： amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

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Aerodynamic performance of bowed compressor cascades with different camber angles

CHEN Shaowen, CHEN Fu, WANG Keli, GU Jun, WANG Zhongqi

Frontiers in Energy 2008, Volume 2, Issue 3,   Pages 306-312 doi: 10.1007/s11708-008-0056-8

Abstract: results show that the value of the optimum bowed angle and optimum bowed height decrease because of the increased

Keywords： increase     different     blockage     increased     ink-trace    

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Cavitation in semi-open centrifugal impellers for a miniature pump

LUO Xianwu, LIU Shuhong, ZHANG Yao, XU Hongyuan

Frontiers in Energy 2008, Volume 2, Issue 1,   Pages 31-35 doi: 10.1007/s11708-008-0011-8

Abstract: performances as an ordinary-size pump, with the cavitation performance of the semi-open impeller reduced by increased

Keywords： cavitation performance     semi-open impeller     increased     two-dimensional     efficiency    

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Title Author Date Type Operation

Developing a new agenda for increased food and climate security

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

Predication of increased plasma homocysteine level on the prognosis of Chinese patients with first-onset

YAN Jiangtao, SHAO Jiaomei, WANG Daowen, YUE Zhengliang, HUI Rutai

Journal Article

Cotransfecting norepinephrine transporter and vesicular monoamine transporter 2 genes for increased retention

Yanlin Zhao,Xiao Zhong,Xiaohong Ou,Huawei Cai,Xiaoai Wu,Rui Huang

Journal Article

Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic

Chun Yang, Xiaomin Li, Nan Wang, Shixia Xu, Jianjun Yang, Zhiqiang Zhou

Journal Article

Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

Yang Sun,Chenze Li,Lina Zhang,Dong Hu,Xudong Zhang,Ting Yu,Min Tao,Dao Wen Wang,Xiaoqing Shen

Journal Article

Optimal Su-Do-Ku based interconnection scheme for increased power output from PV array under partial

P. SRINIVASA RAO,P. DINESH,G. SARAVANA ILANGO,C. NAGAMANI

Journal Article

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

Journal Article

Aerodynamic performance of bowed compressor cascades with different camber angles

CHEN Shaowen, CHEN Fu, WANG Keli, GU Jun, WANG Zhongqi

Journal Article

Cavitation in semi-open centrifugal impellers for a miniature pump

LUO Xianwu, LIU Shuhong, ZHANG Yao, XU Hongyuan

Journal Article