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is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent fibrinolysis and matrix invasion

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract:

Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusion protein causes lethal hyperfibrinolysis in acute promyelocytic leukemia (APL), but the mechanism is unclear. To facilitate the investigation of regulatory association between ANXA2 and promyelocytic leukemia/retinoic acid receptor a (PML/RARα) fusion protein, this work was performed to determine the transcription start site of ANXA2 promoter with rapid amplification of 5′-cDNA ends analysis. Zinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2 transcripts and translational expressions of both ANXA2 and S100A10, while S100A10 transcripts remained constitutive. The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higher than that by control pSG5 vector or wild-type RARα. The overexpression of ANXA2 in U937 transfected with full-length ANXA2 cDNA was associated with increased S100A10 subunit, although S100A10 transcripts remained constitutive. The tPA-dependent initial rate of plasmin generation (IRPG) in zinc-treated U937/PR9 increased by 2.13-fold, and cell invasiveness increased by 27.6%. Antibodies against ANXA2, S100A10, or combination of both all remarkably inhibited the IRPG and invasiveness in U937/PR9 and NB4. Treatment of zinc-induced U937/PR9 or circulating APL blasts with all-trans retinoic acid (ATRA) significantly reduced cell surface ANXA2 and S100A10 and associated reductions in IRPG and invasiveness. Thus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate S100A10. Increased AIIt promoted IRPG and invasiveness, both of which were partly abolished by antibodies against ANXA2 and S100A10 or by ATRA.

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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Disabled homolog 2 is required for migration and invasion of prostate cancer cells

Yinyin Xie,Yuanliang Zhang,Lu Jiang,Mengmeng Zhang,Zhiwei Chen,Dan Liu,Qiuhua Huang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 312-321 doi: 10.1007/s11684-015-0401-3

Abstract: the tumorigenicity, whereas DAB2 overexpression enhanced LNCaP cell migration and invasion

Keywords： DAB2     prostate cancer     migration     invasion     acetylation    

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on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 649-656 doi: 10.1007/s11684-021-0830-0

Abstract: immune microenvironment, participate in epithelial–mesenchymal transition, and then regulate tumor invasionare abnormally expressed in many types of tumors and are highly correlated with tumor migration and invasionMGLL, their relationship with abnormal lipid metabolism, and the mechanism of the regulation of tumor invasionand metastasis and reviews the research progress of the relationship of FASN and MGLL with tumor invasion

Keywords： FASN     MGLL     lipid metabolism     tumor invasion     metastasis    

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Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 456-463 doi: 10.1007/s11684-014-0353-z

Abstract: of miRNA-200c (miR-200c) on the biological behavior and mechanism of proliferation, migration, and invasionThe proliferation, migration, and invasion abilities of Du145 cells were detected by CCK8 assays, migrationassays and invasion assays, respectively.then transfected with miR-200c mimics and displayed lower abilities of proliferation, migration, and invasionproliferation of the prostate cancer cell line Du145; likewise, miR-200c could inhibit migration and invasion

Keywords： miR-200c     proliferation     migration     invasion     prostate cancer     Du145 cell     ZEB1    

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Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 303-308 doi: 10.1007/s11684-009-0060-3

Abstract: The effects of hypoxia on the invasion and the related protein expression of Hela cells and the roleThe scratch test and the invasion assay were applied to examine the invasion in each group.It was concluded that the effects of hypoxia on the invasion of human cervical cancer Hela cells and

Keywords： hypoxia     actin     β     -catenin     E-cadherin     invasion    

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The Characteristics of Mangrove Wetlands and Some Ecological Engineering Questions in China

Lin Peng

Strategic Study of CAE 2003, Volume 5, Issue 6,   Pages 33-38

Abstract: afforestation; 2) The ecological models of sea beach building in mangrove areas; 3) Prevention of ecological invasion

Keywords： mangroves     wetlands     ecological rehabilitation     ecological invasion    

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A Discussion of Ecological Engineering Benefits of Spartina spp and Its Ecological Invasion

Tang Tinggui,Zhang Wanjun

Strategic Study of CAE 2003, Volume 5, Issue 3,   Pages 15-20

Abstract: Therefore Spartina alterniflora and S. anglica are not ecological invasion species.

Keywords： coastal zone     spartina     ecological engineering     created land with silt     protecting seacoast    

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Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 336-340 doi: 10.1007/s11684-009-0053-2

Abstract: to inhibit the high expression of in carcinoma cells and play a clue for inhibiting the growth and invasion

Keywords： proliferation     c-met     invasion     lanthanum chloride    

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Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver, gallbladder, and duodenum

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 434-437 doi: 10.1007/s11684-011-0157-3

Abstract: Locally advanced colorectal cancer complicated with adjacent organic invasion may remain confined towe report on a patient with advanced right colon cancer, including liver, gallbladder, and duodenal invasion

Keywords： liver abscess     locally advanced colon cancer     multiorganic invasion    

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Optimized deployment of a radar network based on an improved firefly algorithm Regular Papers

Xue-jun ZHANG, Wei JIA, Xiang-min GUAN, Guo-qiang XU, Jun CHEN, Yan-bo ZHU

Frontiers of Information Technology & Electronic Engineering 2019, Volume 20, Issue 3,   Pages 425-437 doi: 10.1631/FITEE.1800749

Abstract:

The threats and challenges of unmanned aerial vehicle (UAV) invasion defense due to rapid UAV developmentOne of the important UAV invasion defense methods is radar network detection.

Keywords： firefly algorithm     Radar surveillance network     Deployment optimization     Unmanned aerial vehicle (UAV) invasion    

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Title Author Date Type Operation

is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent fibrinolysis and matrix invasion

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

Disabled homolog 2 is required for migration and invasion of prostate cancer cells

Yinyin Xie,Yuanliang Zhang,Lu Jiang,Mengmeng Zhang,Zhiwei Chen,Dan Liu,Qiuhua Huang

Journal Article

on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion

Jingyue Zhang, Yawen Song, Qianqian Shi, Li Fu

Journal Article

Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and

Runlin Shi,Haibing Xiao,Tao Yang,Lei Chang,Yuanfeng Tian,Bolin Wu,Hua Xu

Journal Article

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Journal Article

The Characteristics of Mangrove Wetlands and Some Ecological Engineering Questions in China

Lin Peng

Journal Article

A Discussion of Ecological Engineering Benefits of Spartina spp and Its Ecological Invasion

Tang Tinggui,Zhang Wanjun

Journal Article

Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

Journal Article

Pyogenic liver abscess as initial presentation in locally advanced right colon cancer invading the liver, gallbladder, and duodenum

Kai Qu, Chang Liu, Aasef M A Mansoor, Bo Wang, Jincai Chen, Liang Yu, Yi Lv

Journal Article

Optimized deployment of a radar network based on an improved firefly algorithm

Xue-jun ZHANG, Wei JIA, Xiang-min GUAN, Guo-qiang XU, Jun CHEN, Yan-bo ZHU

Journal Article