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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: Mechanistically, FRMD6 interacts and colocalizes with mTOR and S6K, which are the key molecules of themTOR signaling pathway.FRMD6 markedly enhances the interaction between mTOR and S6K, subsequently increasing the levels of endogenousFurthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6Altogether, our results show that FRMD6 contributes to lung cancer progression by activating the mTOR

Keywords: FRMD6     lung cancer     mTOR pathway    

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: The mammalian target of rapamycin (mTOR) critically regulates several essential biological functions,cell growth, metabolism, survival, and immune response by forming two important complexes, namely, mTORcomplex 1 (mTORC1) and complex 2 (mTORC2). mTOR signaling is often dysregulated in cancers and has beenGreat efforts have been made to develop efficacious mTOR inhibitors, particularly mTOR kinase inhibitorstherapeutic strategies with mTOR inhibitors against cancer.

Keywords: mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 448-459 doi: 10.1007/s11684-020-0805-6

Abstract: The PI3K–Akt–mTOR axis is one of the most frequently modified signaling pathways whose activation sustainsFK506 binding protein 8 (FKBP8) is an intrinsic inhibitor of mTOR kinase that also exerts an anti-apoptoticFurthermore, the downregulation of PHB1 inhibited the proliferation of ovarian cancer cells and the mTORMoreover, concomitant with these changes, the interaction between FKBP8 and mTOR substantially increasedfinding highlights PHB1 as a potential regulator of FKBP8 because of its subcellular localization and mTOR

Keywords: prohibitin 1     FKBP8     mTOR     cell proliferation     cancer    

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 697-706 doi: 10.1007/s11684-018-0655-7

Abstract: Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway.suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR

Keywords: resveratrol     reactive oxygen species     AMPK     mTOR     autophagy    

Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 3,   Pages 222-230 doi: 10.15302/J-FASE-2016106

Abstract: During their growth and development, animals adapt to tremendous changes in order to survive. These include responses to both environmental and physiological changes and autophagy is one of most important adaptive and regulatory mechanisms. Autophagy is defined as an autolytic process to clear damaged cellular organelles and recycle the nutrients via lysosomic degradation. The process of autophagy responds to special conditions such as nutrient withdrawal. Once autophagy is induced, phagophores form and then elongate and curve to form autophagosomes. Autophagosomes then engulf cargo, fuse with endosomes, and finally fuse with lysosomes for maturation. During the initiation process, the ATG1/ULK1 (unc-51-like kinase 1) and VPS34 (which encodes a class III phosphatidylinositol (PtdIns) 3-kinase) complexes are critical in recruitment and assembly of other complexes required for autophagy. The process of autophagy is regulated by autophagy related genes (ATGs). Amino acid and energy starvation mediate autophagy by activating mTORC1 (mammalian target of rapamycin) and AMP-activated protein kinase (AMPK). AMPK is the energy status sensor, the core nutrient signaling component and the metabolic kinase of cells. This review mainly focuses on the mechanism of autophagy regulated by nutrient signaling especially for the two important complexes, ULK1 and VPS34.

Keywords: Autophagy     ULK1 complex     VPS34 complex     AMPK     mTOR     nutrient signaling    

Diet Enhances Muscle Weight and Postprandial Protein Synthesis of Skeletal Muscle by Promoting the mTOR

Bo Zhang, Licui Chu, Hong Liu, Chunyuan Xie, Shiyan Qiao, Xiangfang Zeng

Engineering 2017, Volume 3, Issue 5,   Pages 760-765 doi: 10.1016/J.ENG.2017.03.008

Abstract: were harvested and weighed, and the fractional synthesis rate (FSR) and mammalian target of rapamycin (mTORsupplementation moderately improves body weight gain and increases muscle protein synthesis through mTOR

Keywords: Low-protein diet     Leucine     Growth performance     Muscle weight     Protein synthesis     Adult rats    

Title Author Date Type Operation

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Prohibitin regulates mTOR pathway via interaction with FKBP8

Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu

Journal Article

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Journal Article

Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Journal Article

Diet Enhances Muscle Weight and Postprandial Protein Synthesis of Skeletal Muscle by Promoting the mTOR

Bo Zhang, Licui Chu, Hong Liu, Chunyuan Xie, Shiyan Qiao, Xiangfang Zeng

Journal Article