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2013 1

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acetaminophen 1

crystallization 1

induction time 1

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metastable zone width 1

supersaturation control 1

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Effects of a structurally related substance on the crystallization of paracetamol

Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 79-87 doi: 10.1007/s11705-013-1308-7

Abstract: Paracetamol (PCM) was crystallized from an isopropanol (IPA) solution containing various small amounts of metacetamolSmall amounts of metacetamol (1–4 mol-%) were found to cause significant inhibition to the nucleationThe dissolution rate of paracetamol was improved by the incorporation of metacetamol with 4 mol-% havingA supersaturation control (SSC) approach was implemented for the PCM-IPA system with and without metacetamolin an attempt to control and obtain larger metacetamol-doped paracetamol crystals.

Keywords: acetaminophen     metacetamol     crystallization     metastable zone width     induction time     supersaturation control    

Title Author Date Type Operation

Effects of a structurally related substance on the crystallization of paracetamol

Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY

Journal Article