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chicken 1

chronic kidney disease 1

epigenetic modification 1

hepatocellular carcinoma 1

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mineral bone disorder 1

nonalcoholic fatty liver disease 1

nonalcoholic steatohepatitis 1

skeletal muscle development 1

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Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 378-385 doi: 10.1007/s11684-017-0541-8

Abstract: meta-signature that characterizes the significant intersection of differentially expressed mRNA and expected miRNAsregulation based on weighted ranked expression and putative microRNA targets (IMRE) method to identify miRNAsDifferentially expressed miRNAs associated with CKD-MBD were identified through a computational analysis

Keywords: chronic kidney disease     microRNA     mineral bone disorder     uremia    

miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 389-396 doi: 10.1007/s11684-016-0468-5

Abstract: cause of liver cirrhosis and hepatocellular carcinoma and is a considerable threat to public health. miRNAsare important post-transcriptional regulators of gene expression, and the dysregulation of miRNAs ishave shown that circulating miRNAs reflect histological changes in the liver.Therefore, circulating miRNAs have potential use for the evaluation of NAFLD severity.In this review, we discuss the involvement of miRNAs in NAFLD pathogenesis and the key role of miRNAs

Keywords: nonalcoholic fatty liver disease     nonalcoholic steatohepatitis     hepatocellular carcinoma     miRNA    

The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 295-304 doi: 10.15302/J-FASE-2017159

Abstract: Skeletal muscle development is a complex multi-process trait regulated by various genetic factors. The chicken embryo is an ideal model system for studying skeletal muscle development. However, only a small proportion of the genetic factors affecting skeletal muscle development have been identified in chicken. The aim of this review is to summarize recent knowledge about the genetic factors involved in the regulation of skeletal muscle development in the chicken, such as gene polymorphisms, epigenetic modification, noncoding RNAs and transcription factors, which can influence skeletal muscle development at the genome, epigenome, transcriptome and proteome levels. Research on the regulation of skeletal muscle development in chicken is not yet comprehensive and most of the candidate genes and single nucleotide polymorphisms related to chicken muscle growth remain to be verified in experimental studies. In addition, the data derived from transcriptome sequencing and genome-wide association studies still require further investigation and analysis and comprehensive studies on the regulation of chicken skeletal muscle development will continue as a major research focus.

Keywords: chicken     epigenetic modification     miRNAs     skeletal muscle development     SNP     transcription factor    

Title Author Date Type Operation

Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Journal Article

miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Journal Article

The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Journal Article