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Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4

Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5, Pages 880-888 doi: 10.1007/s11705-019-1864-6

Abstract: The tubulin staining study indicates that Azo-CA4 loses the potency of switching off microtubule dynamics

Keywords： hypoxia microtubule inhibitor drug delivery azo-combretastatin A4 photo-responsive

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Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 102-110 doi: 10.1007/s11684-021-0850-9

Abstract: January 2020 to March 2020 to investigate the association between the use of renin–angiotensin system inhibitorAssociations between the use of RAS-I (angiotensin-converting enzyme inhibitor (ACEI) or angiotensin

Keywords： COVID-19 RAS inhibitor hypertension all-cause mortality

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Comparison between inhibitor and uncoupler for minimizing excess sludge production of an activated sludge

CHEN Guowei, XI Pengge, XU Deqian, YU Hanqing

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1, Pages 63-66 doi: 10.1007/s11783-007-0012-6

Abstract: minimization of excess sludge production, the reduction in the excess sludge production in the presence of an inhibitor

Keywords： uncoupling coefficient Cu minimization presence uncoupling

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 403-409 doi: 10.1007/s11684-017-0522-y

Abstract:

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation

Keywords： arterial thrombosis conditional knockout mice tissue factor pathway inhibitor vascular smooth muscle

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Estimating the effect of urease inhibitor on rice yield based on NDVI at key growth stages

Kailou LIU,Yazhen LI,Huiwen HU

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2, Pages 150-157 doi: 10.15302/J-FASE-2014028

Abstract: The effect of the urease inhibitor, N-(n-butyl) thiophosphoric triamide (NBPT) at a range of applicationTherefore, it was feasible to estimate rice yield for different amounts of urease inhibitor using NDVI

Keywords： normalized difference vegetation index (NDVI) N-(n-butyl) thiophosphoric triamide (NBPT) rice grain yield

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A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 275-289 doi: 10.1007/s11684-022-0945-y

Abstract: treatment of nasopharyngeal carcinoma (NPC) and explored the anti-tumor effects of the novel pan-HER inhibitorThe pan-HER inhibitor HM781-36B alone or in combination with cisplatin represents promising therapeutic

Keywords： epidermal growth factor receptor ErbB receptors HM781-36B nasopharyngeal carcinoma molecular targeted therapy cisplatin

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Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 467-482 doi: 10.1007/s11684-021-0869-y

Abstract: resistance to cMet inhibitors, and the combination of cabozantinib and mammalian target of rapamycin (mTOR) inhibitorformation of human umbilical vascular endothelial cells and human growth factor-induced invasion of cMet inhibitor-resistant

Keywords： hepatocellular carcinoma cabozantinib primary resistance rapamycin

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Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken

Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3, Pages 242-249 doi: 10.15302/J-FASE-2014018

Abstract: This dermal hyperpigmentation phenotype is controlled by the sex-linked inhibitor of dermal melanin gene

Keywords： sex-linked inhibitor of dermal melanin (Id) Silkie chromosome Z

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Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Frontiers of Medicine 2020, Volume 14, Issue 3, Pages 273-283 doi: 10.1007/s11684-019-0728-2

Abstract: Up until 2017, treatment of advanced HCC was largely limited to sorafenib, an oral tyrosine kinase inhibitor

Keywords： hepatocellular carcinoma tyrosine kinase inhibitor check point inhibitor anti-angiogenesis

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Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 415-420 doi: 10.1007/s11684-009-0072-z

Abstract: this study was to investigate the inhibitory effects of recombinant adenovirus vector carrying tissue inhibitor

Keywords： tissue inhibitor of metalloproteinase-3 intervertebral disc rabbit gene therapy

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Fe–Cr–Ni based alloys exposed to molten MgCl₂–KCl–NaCl salt with over-added Mg corrosion inhibitor

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10, Pages 1608-1619 doi: 10.1007/s11705-023-2349-1

Abstract: Adding Mg into molten MgCl₂–NaCl–KCl salt as a corrosion inhibitor is one of the most effectivedirect contact of liquid Mg with Ni-containing alloys should be avoided during using Mg as a corrosion inhibitor

Keywords： concentrated solar power (CSP) Mg corrosion inhibitor Mg–Ni intermetallic salt purification thermal

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The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of

Shixin ZHANG,Shaohua WU,Weimin TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 4, Pages 357-362 doi: 10.15302/J-FASE-2016125

Abstract: using an experimental morphological technique, the present study revealed that trichostatin A (TSA), an inhibitor

Keywords： Hevea brasiliensis histone acetylation laticifer differentiation trichostatin vascular cambia

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Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 437-443 doi: 10.1007/s11684-016-0472-9

Abstract:

A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib

Keywords： JAK ruxolitinib Chinese patients myelofibrosis

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Frontiers of Medicine 2019, Volume 13, Issue 4, Pages 427-437 doi: 10.1007/s11684-018-0672-6

Abstract: Desmoid-type fibromatosis (DF) is a rare monoclonal fibroblastic proliferation that is characterized by locally infiltrative but rarely metastatic lesions. Tyrosine kinase and γ-secretase inhibitors are primarily used in the targeted therapy of DF. The use of these drugs, however, is mainly based on the recommendations of retrospective studies with small sample sizes. Previous studies that focused on the mechanism, efficacy, and safety of targeted therapy for DF were reviewed to provide references for clinical applications and research. The efficacy and safety of targeted therapy were compared with those of other systemic therapy options. Targeted therapy does not provide considerable advantages in efficacy and safety over other medical treatments and is usually applied after the failure of antihormonal therapies, nonsteroidal anti-inflammatory drugs, and chemotherapy. Further studies are required to explore the mechanism, indications, and appropriate drug dosage of the targeted therapy of DF.

Keywords： targeted therapy desmoid-type fibromatosis tyrosine kinase inhibitor γ-secretase inhibitor

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Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 153-157 doi: 10.1007/s11684-009-0034-5

Abstract: To clarify the effect of DNA methylation and histone deacetylase inhibitors on the expression of the E-cadherin gene and the invasiveness of the QBC cells, the QBC cells were separately treated with hydralazine, valproate, or combination of the two drugs. The mRNA expression of E-cadherin was examined with reverse transcription-polymerase chain reaction (RT-PCR), the protein of the gene with Western blotting. The methylation status of the promoter region of the gene was detected with methylation-specific PCR (MSP). The invasiveness of QBC cells was detected with transwell assay. It was found that the promoter region of the E-cadherin gene of QBC cells was hypermethylated. Valproate alone could not contribute to demethylation of the gene, whereas hydralazine could make them to be partly demethylated. However, the methylation status of the gene could be thoroughly reversed by using valproate and hydralazine in combination. What’s more, it was confirmed that the E-cadherin gene of QBC cells could not be transcriptionally reactivated by Valproate alone, whereas hydralazine alone could induce moderate reexpression of the gene. However, using valproate and hydralazine in combination could result in robust reexpression of the E-cadherin gene ( =0.000). Likewise, the invasiveness of the QBC939 cells was sharply decreased by treatment with two drugs in combination and slightly decreased with one drug alone. It could be concluded that the two drugs have synergistic effect on the demethylation and reexpression of the E-cadherin gene of QBC cells, and also on the reduction of the invasiveness of the QBC939 cells.

Keywords： DNA methylation inhibitor histone deacetylase inhibitor bile duct carcinoma E-cadherin

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Title Author Date Type Operation

Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4

Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang

Journal Article

Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID

Journal Article

Comparison between inhibitor and uncoupler for minimizing excess sludge production of an activated sludge

CHEN Guowei, XI Pengge, XU Deqian, YU Hanqing

Journal Article

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Journal Article

Estimating the effect of urease inhibitor on rice yield based on NDVI at key growth stages

Kailou LIU,Yazhen LI,Huiwen HU

Journal Article

A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal

Journal Article

Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

Journal Article

Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken

Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI

Journal Article

Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Journal Article

Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Journal Article

Fe–Cr–Ni based alloys exposed to molten MgCl₂–KCl–NaCl salt with over-added Mg corrosion inhibitor

Journal Article

The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of

Shixin ZHANG,Shaohua WU,Weimin TIAN

Journal Article

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential

Xin Du,Daobin Zhou

Journal Article

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Journal Article

Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Journal Article

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