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Frontiers of Engineering Management 2022, Volume 9, Issue 2, Pages 221-238 doi: 10.1007/s42524-022-0195-3
Keywords: knowledge transfer knowledge management project management project environment literature review
Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy
Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li
Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 386-392 doi: 10.1007/s11684-017-0574-z
Keywords: diabetic nephropathy clinical characteristics renal biopsy outcomes
Clinical manifestations and outcomes in severe ulcerative colitis
YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin
Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 192-195 doi: 10.1007/s11684-007-0036-0
RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping
Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 157-160 doi: 10.1007/s11684-007-0029-z
Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in
WANG Zhiqiang
Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 171-173 doi: 10.1007/s11684-008-0031-0
Keywords: significant difference predictive medication first-line treatment bleeding
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
Shi-Yong Sun
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 221-231 doi: 10.1007/s11684-020-0812-7
Keywords: mTOR cancer therapy resistance GSK3 protein degradation E3 ubiquitin ligase PD-L1
Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 91-95 doi: 10.1007/s11684-014-0305-7
Keywords: ovarian carcinoma prognostic factors surgery chemotherapy survival
Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 86-93 doi: 10.1007/s11684-011-0118-x
Keywords: adeno-associated virus angiogenesis gene transfer ischemia middle cerebral artery occlusion netrin-1
Jing Yue, Bo Zhang, Mingyue Wang, Junning Yao, Yifan Zhou, Ding Ma, Lei Jin
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 121-125 doi: 10.1007/s11684-018-0615-2
Keywords: antitubercular treatment pregnancy prognosis genital tuberculosis
Xiangwei Li, Yu Yang, Jianmin Liu, Feng Zhou, Wei Cui, Ling Guan, Fei Shen, Cong Gao, Mufei Li, Qi Jin, Lei Gao
Frontiers of Medicine 2013, Volume 7, Issue 3, Pages 354-366 doi: 10.1007/s11684-013-0257-3
Keywords: tuberculosis treatment outcome China meta-analysis
Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 718-727 doi: 10.1007/s11684-020-0807-4
Keywords: severe aplastic anemia non-severe acquired aplastic anemia haploidentical bone marrow transplantation outcomes
Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 231-239 doi: 10.1007/s11684-022-0939-9
Keywords: neoadjuvant radiotherapy oligometastatic prostate cancer radical prostatectomy
Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin
Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 518-524 doi: 10.1007/s11684-017-0575-y
The increased levels of intracellular reactive oxygen species (ROS) in granulosa cells (GCs) may affect the pregnancy results in women with polycystic ovary syndrome (PCOS). In this study, we compared thein vitro fertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factor infertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group had significantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factor group (P<0.05); however, the number of retrieved oocytes was not significantly different between the two groups (P>0.05). PCOS group had slightly lower fertilization, cleavage, grade I/II embryo, clinical pregnancy, and implantation rates and higher miscarriage rate than the tubal factor group (P>0.05). We further found a significantly higher ROS level of GCs in the PCOS group than in the tubal factor group (P<0.05). The increased ROS levels in GCs caused GC apoptosis, whereas NADPH oxidase 2 (NOX2) specific inhibitors (diphenyleneiodonium and apocynin) significantly reduced the ROS production in the PCOS group. In conclusion, the increased ROS expression levels in PCOS GCs greatly induced cell apoptosis, which further affected the oocyte quality and reduced the positive IVF-ET pregnancy results of women with PCOS. NADPH oxidase pathway may be involved in the mechanism of ROS production in GCs of women with PCOS.
Keywords: PCOS ROS granulosa cell IVF-ET NADPH oxidase
Ye Yin, Ge Chen, Kezhen Li, Qiuyue Liao, Sijia Zhang, Nieying Ma, Jing Chen, Yan Zhang, Jihui Ai
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 563-569 doi: 10.1007/s11684-017-0535-6
The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer
Keywords: blastocyst embryo transfer cumulative pregnancy rate cumulative live birth rate IVF
Farhad Sahebjam,John M. Vierling
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 187-219 doi: 10.1007/s11684-015-0386-y
Autoimmune hepatitis is a chronic liver disease putatively caused by loss of tolerance to hepatocyte-specific autoantigens. It is characterized by female predilection, elevated aminotransferase levels, autoantibodies, increased γ-globulin or IgG levels and biopsy evidence of interface hepatitis. It is currently divided into types 1 and 2, based on expression of autoantibodies. Autoantigenic epitopes have been identified only for the less frequent type 2. Although autoimmune hepatitis occurs in childhood, this review focuses on disease in adults. In the absence of pathognomonic biomarkers, diagnosis requires consideration of clinical, biochemical, serological and histological features, which have been codified into validated diagnostic scoring systems. Since many features also occur in other chronic liver diseases, these scoring systems aid evaluation of the differential diagnosis. New practice guidelines have redefined criteria for remission to include complete biochemical and histological normalization on immunosuppressive therapy. Immunosuppression is most often successful using prednisone or prednisolone and azathioprine; however, the combination of budesonide and azathioprine for non-cirrhotic patients offers distinct advantages. Patients failing standard immunosuppression are candidates for alternative immunosuppressive regimens, yet none of the options has been studied in a randomized, controlled trial. Overlap syndromes with either primary sclerosing cholangitis or primary biliary cirrhosis occur in a minority. Liver transplantation represents a life-saving option for patients presenting with acute liver failure, severely decompensated cirrhosis or hepatocellular carcinoma. Transplant recipients are at risk for recurrent autoimmune hepatitis in the allograft, and de novo disease may occur in patients transplanted for other indications. Patients transplanted for AIH are also at risk for recurrent or de novo inflammatory bowel disease. Progress in our understanding of the immunopathogenesis should lead to identification of specific diagnostic and prognostic biomarkers and new therapeutic strategies.
Keywords: autoantibodies diagnosis immunological diseases drug-induced liver injury therapy immunosuppression outcomes
Title Author Date Type Operation
Linking elements to outcomes of knowledge transfer in the project environment: Current review and future
Journal Article
Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy
Li Zhuo, Nianrong Zhang, Guming Zou, Dapeng Chen, Wenge Li
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Clinical manifestations and outcomes in severe ulcerative colitis
YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin
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Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma
RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping
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Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in
WANG Zhiqiang
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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
Shi-Yong Sun
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Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line
Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie
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Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral
Haiyan LU, Yongting WANG, Falei YUAN, Jianrong LIU, Lili ZENG, Guo-Yuan YANG
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Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis
Jing Yue, Bo Zhang, Mingyue Wang, Junning Yao, Yifan Zhou, Ding Ma, Lei Jin
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Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis
Xiangwei Li, Yu Yang, Jianmin Liu, Feng Zhou, Wei Cui, Ling Guan, Fei Shen, Cong Gao, Mufei Li, Qi Jin, Lei Gao
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Outcomes of haploidentical bone marrow transplantation in patients with severe aplastic anemia-II that
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Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes
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Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with
Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin
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Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo
Ye Yin, Ge Chen, Kezhen Li, Qiuyue Liao, Sijia Zhang, Nieying Ma, Jing Chen, Yan Zhang, Jihui Ai
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