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Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellularcarcinoma

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 467-482 doi: 10.1007/s11684-021-0869-y

Abstract: vascular endothelial growth factor receptor 2, is the second-line treatment for patients with advanced hepatocellularcarcinoma (HCC).In this study, we found that cMet-low HCC cells showed primary resistance to cMet inhibitors, and the

Keywords： hepatocellular carcinoma     cabozantinib     primary resistance     rapamycin    

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Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 183-190 doi: 10.1007/s11684-016-0440-4

Abstract: weighted gene coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellularcarcinoma (HCC).

Keywords： hepatocellular carcinoma     coexpression     module     microarray     prognosis    

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The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 33-41 doi: 10.1007/s11684-013-0301-3

Abstract:

Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC).

Keywords： hypoxia     hepatocellular carcinoma (HCC)     metastasis     hypoxia-inducible factor (HIF)    

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Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 273-283 doi: 10.1007/s11684-019-0728-2

Abstract: In terms of global cancer-related deaths, hepatocellular carcinoma (HCC) has the fourth highest mortality

Keywords： hepatocellular carcinoma     tyrosine kinase inhibitor     check point inhibitor     anti-angiogenesis    

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Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract: expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellularcarcinoma (HCC).

Keywords： osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic    

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Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract:

Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading

Keywords： natural killer cell     hepatocellular carcinoma     immunotherapy    

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Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric

Jianpeng Liu, Xinhua Chen, Shusen Zheng

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 170-177 doi: 10.1007/s11684-020-0747-z

Abstract: Recent animal experiments show that nsPEF can induce the immunogenic cell death of hepatocellular carcinoma

Keywords： nanosecond pulsed electric fields (nsPEF)     hepatocellular carcinoma (HCC)     immune response     recurrence     metastasis    

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Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 191-202 doi: 10.1007/s11684-017-0512-0

Abstract:

Primary hepatic carcinoma (PHC) is a common malignant tumor in China.systematic review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primaryhepatic carcinoma.

Keywords： traditional Chinese medicine     primary hepatic carcinoma     meta-analysis    

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Advances in managing hepatocellular carcinoma

Marielle Reataza,David K. Imagawa

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 175-189 doi: 10.1007/s11684-014-0332-4

Abstract:

Multiple modalities for treatment of hepatocellular carcinoma are available, depending on tumor sizeCurrently, sorafenib is the only US Food and Drug Administration-approved chemotherapeutic for hepatocellularcarcinoma.This review serves to emphasize the current and new technologies emerging in the treatment of hepatocellularcarcinoma.

Keywords： hepatocellular carcinoma     radiofrequency ablation     microwave ablation     chemoembolization     radioembolization    

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Translational medicine in hepatocellular carcinoma

Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 122-133 doi: 10.1007/s11684-012-0193-7

Abstract:

Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly

Keywords： hepatocellular carcinoma     molecular classification     molecular targeted therapies     tumor microenvironment    

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Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated

Guanghua Rong,Wenlin Bai,Zheng Dong,Chunping Wang,Yinying Lu,Zhen Zeng,Jianhui Qu,Min Lou,Hong Wang,Xudong Gao,Xiujuan Chang,Linjing An,Yan Chen,Yongping Yang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 63-71 doi: 10.1007/s11684-014-0342-2

Abstract:

Cryoablation is a less prevalent percutaneous ablative therapy for hepatocellular carcinoma (HCC),

Keywords： hepatocellular carcinoma     percutaneous cryoablation     efficacy     safety    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma

Frontiers of Medicine doi: 10.1007/s11684-022-0978-2

Abstract: The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellularcarcinoma (HCC).

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

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polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations with hepatocellularcarcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: nbsp;gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the risk of hepatocellularcarcinoma (HCC).

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 476-492 doi: 10.1007/s11684-022-0966-6

Abstract: However, their exact presence and function in hepatocellular carcinoma (HCC) remain unclear.

Keywords： EIF4A1     G-quadruplex     hepatocellular carcinoma     tRNA-derived small RNA     translation initiation    

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Title Author Date Type Operation

Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellularcarcinoma

Journal Article

Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Journal Article

The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Journal Article

Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Journal Article

Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric

Jianpeng Liu, Xinhua Chen, Shusen Zheng

Journal Article

Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Journal Article

Advances in managing hepatocellular carcinoma

Marielle Reataza,David K. Imagawa

Journal Article

Translational medicine in hepatocellular carcinoma

Qiang Gao, Yinghong Shi, Xiaoying Wang, Jian Zhou, Shuangjian Qiu, Jia Fan

Journal Article

Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated

Guanghua Rong,Wenlin Bai,Zheng Dong,Chunping Wang,Yinying Lu,Zhen Zeng,Jianhui Qu,Min Lou,Hong Wang,Xudong Gao,Xiujuan Chang,Linjing An,Yan Chen,Yongping Yang

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma

Journal Article

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations with hepatocellularcarcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction

Journal Article