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antibiotic resistance 2

resistome 2

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Bacterial taxonomy 1

Biofiltration 1

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract: ecological point of view, the important research progress regarding the collective ARGs (antibiotic resistome

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Antibiotic resistome of : molecular determinants for the emergence of drug resistance

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 693-703 doi: 10.1007/s11684-020-0777-6

Abstract: Resistome is a cluster of microbial genes encoding proteins with necessary functions to resist the actionResistome governs essential and separate biological functions to develop resistance against antibioticsof antibiotics over the years have combined to select antibiotic-resistant determinants and develop resistomeAntibiotic resistome is a dynamic and ever-expanding component in Salmonella.The foundation of resistome in Salmonella is laid long before; therefore, the antibiotic resistome

Keywords： S. typhi     antibiotic resistance     mechanism     resistome     identification methods    

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Antibiotic resistome mostly relates to bacterial taxonomy along a suburban transmission chain

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 3, doi: 10.1007/s11783-021-1466-7

Abstract:

• The α-diversities of resistome were lower in manure and compost than

Keywords： Antibiotic resistance genes     Resistome     Bacterial taxonomy     Transmission chain    

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Biofiltration and disinfection codetermine the bacterial antibiotic resistome in drinking water: A review

Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1189-1

Abstract: The bacterial antibiotic resistome (BAR) is one of the most serious contemporary medical challenges.biofiltration and chlorination were discovered to play important roles in shaping the bacterial antibiotic resistomeBoth biofiltration and chlorination altered the structure of the resistome by affecting relative ARGanalyzed the mechanism behind the impact of biofiltration and chlorination on the bacterial antibiotic resistome

Keywords： Drinking water treatment     Antibiotic resistance gene     Biofiltration     Chlorination    

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Culturomics and metagenomics: In understanding of environmental resistome

Monika Nowrotek, Łukasz Jałowiecki, Monika Harnisz, Grażyna Anna Płaza

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1121-8

Abstract:

State of the art of culturomics and metagenomics to study resistome

Keywords： Culturomics     Metagenomics     Antibiotic resistance     Resistome    

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Three-Year Consecutive Field Application of Erythromycin Fermentation Residue Following Hydrothermal Treatment: Cumulative Effect on Soil Antibiotic Resistance Genes Article

Ziming Han, Haodi Feng, Xiao Luan, Yunpeng Shen, Liren Ren, Liujie Deng, D.G. Joakim Larsson, Michael Gillings, Yu Zhang, Min Yang

Engineering 2022, Volume 15, Issue 8,   Pages 78-88 doi: 10.1016/j.eng.2022.05.011

Abstract:

Fermentation-based antibiotic production results in abundant nutrient-rich fermentation residue with high potential for recycling, but the high antibiotic residual concentration restricts its usefulness (e.g., in land application as organic fertilizer). In this study, an industrial-scale hydrothermal facility for the treatment of erythromycin fermentation residue (EFR) was investigated, and the potential risk of the long-term soil application of treated EFR promoting environmental antibiotic resistance development was evaluated. The treatment effectively removed bacteria and their DNA, and an erythromycin removal ratio of up to approximately 98% was achieved. The treated EFR was utilized as organic fertilizer for consecutive field applications from 2018 to 2020, with dosages ranging from 3750 to 15 000 kg∙hm－2, resulting in sub-inhibitory levels of erythromycin (ranging from 0.83–76.00 μg∙kg－1) in soils. Metagenomic shotgun sequencing was then used to characterize the antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), and bacterial community composition of the soils. The soil ARG abundance and diversity did not respond to the treated EFR application in the first year, but gradually changed in the second and third year of application. The highest fold change in relative abundance of macrolide-lincosamidestreptogramin (MLS) and total ARGs were 12.59 and 2.75 times, compared with the control (CK; without application), respectively. The soil MGEs and taxonomic composition showed similar temporal trends to those of the ARGs, and appeared to assist in driving increasing ARG proliferation, as revealed by correlation analysis and structural equation models (SEMs). The relative abundance of particular erm resistance genes (RNA methyltransferase genes) increased significantly in the third year of treated EFR application. The close association of erm with MGEs suggested that horizontal gene transfer played a critical role in the observed erm gene enrichment. Metagenomic binning results demonstrated that the proliferation of mac gene-carrying hosts was responsible for the increased abundance of mac genes (efflux pump genes). This study shows that sub-inhibitory levels of erythromycin in soils had a cumulative effect on soil ARGs over time and emphasizes the importance of long-term monitoring for assessing the risk of soil amendment with treated industrial waste.

Keywords： Pharmaceutical manufacturing     Resistome     Antibiotic     Risk assessment     Remediation     Land application    

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Title Author Date Type Operation

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Antibiotic resistome of : molecular determinants for the emergence of drug resistance

Journal Article

Antibiotic resistome mostly relates to bacterial taxonomy along a suburban transmission chain

Journal Article

Biofiltration and disinfection codetermine the bacterial antibiotic resistome in drinking water: A review

Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu

Journal Article

Culturomics and metagenomics: In understanding of environmental resistome

Monika Nowrotek, Łukasz Jałowiecki, Monika Harnisz, Grażyna Anna Płaza

Journal Article

Three-Year Consecutive Field Application of Erythromycin Fermentation Residue Following Hydrothermal Treatment: Cumulative Effect on Soil Antibiotic Resistance Genes

Ziming Han, Haodi Feng, Xiao Luan, Yunpeng Shen, Liren Ren, Liujie Deng, D.G. Joakim Larsson, Michael Gillings, Yu Zhang, Min Yang

Journal Article