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clindamycin phosphate 1

crystal structure 1

moisture stability 1

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Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies

Junbo Gong, Dejiang Zhang, Yuanyuan Ran, Keke Zhang, Shichao Du

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 2,   Pages 220-230 doi: 10.1007/s11705-017-1624-4

Abstract: The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate(solvate V), have been determined by single crystal X-ray diffraction.When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phaseAt the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C.In contrast, solvate V did not transform at any of the humidities studied.

Keywords： clindamycin phosphate     solvate     crystal structure     thermal stability     moisture stability    

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Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies

Junbo Gong, Dejiang Zhang, Yuanyuan Ran, Keke Zhang, Shichao Du

Journal Article