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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract:

Over the past few years, several new achievements have been made from stem cell studies, many of whichMoreover, some stem cell-based products have been approved for marketing by different national regulatoryHowever, many critical issues associated mainly with incomplete understanding of stem cell biology andIn this review, we summarize some new achievements in stem cell studies, especially the preclinical andtherapies abreast of evolvement of stem cell sciences and technologies.

Keywords： stem cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines    

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Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 26-32 doi: 10.1007/s11684-011-0107-0

Abstract: Stem cell therapy, with the ability for self-renewal and potential for multilineage differentiation,Several studies have demonstrated that transplantation of hepatic stem/progenitor cells or hepatocyte-likecells derived from multipotent stem cells leads to donor cell-mediated repopulation of the liver andHowever, a registered clinical application based on stem cell technology will take at least an additionalThis review summarizes the general understanding of the therapeutic potentials of stem cells in liver

Keywords： stem cell     liver disease     regenerative medicine    

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The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: Research into the biological properties and clinical potential of stem cells has spurred strong publicof demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stembasis notwithstanding, hundreds of companies and private clinics around the world now sell putative stemIn this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords： stem cell tourism     medical ethics     stem cell policy and regulation     alternative medicine    

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Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11684-014-0336-0

Abstract:

Stem cells are capable of self-renewal and differentiation, and the processes regulating these eventsIn particular, the molecular mechanisms of the self-renewal, proliferation, and differentiation of stemcombined with proteomics, is one of the most promising approaches to the systemic investigation of stemand proteomic characterization of the different stem cell processes.cell biology and promote the clinical applications of stem cells.

Keywords： embryonic stem cells     transcriptomics     proteomics    

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Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 227-239 doi: 10.1007/s11684-021-0896-8

Abstract: Chronic stress impairs radial neural stem cell (rNSC) differentiation and adult hippocampal neurogenesis

Keywords： cannabidiol     depression     radial neural stem cells     neurogenesis    

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Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 41-47 doi: 10.1007/s11684-012-0175-9

Abstract:

Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial sourceof early stem cells that can be readily manipulated.the most common pluripotent cell, bone marrow-derived MSCs display limitations with the progress of stem

Keywords： umbilical cord     mesenchymal stem cells     cutaneous regeneration    

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Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract: mutations provides the first proof-of-principle investigation on the identification of preleukemic stemAlthough DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneThis is of special importance for the existence of tissue stem cells because they are exclusively immortalImpairment of tissue stem cells is usually accompanied by a reduction in cell number, slows down theIn this study, telomerase activity was measured and compared in breast cancer stem cells and non-stemThe results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
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Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract:

Adult stem cells are responsible for homeostasis and repair of many tissues.Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichIn wound healing and tissue repair, stem cells are mobilized and recruited to the site of wound, andMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesand hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords： stem cell     stem cell niche     electric field     tissue repair    

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Progress, problems and prospects of porcine pluripotent stem cells

Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 6-15 doi: 10.15302/J-FASE-2014009

Abstract: Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), can differentiate

Keywords： induced pluripotent stem cells     embryonic stem cells     pig     reprogramming    

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The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract:

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purposeof gene-targeting, true pluripotent stem cells in this economically important species are still elusivein genome-editing and cloning using homologously recombined somatic cells, the need for pluripotent stempluripotency circuitry across mammalian species may be the main objective for studying pluripotent stem

Keywords： bovine     embryonic     induced     pluripotent stem cells    

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Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 372-378 doi: 10.1007/s11684-011-0164-4

Abstract: an emerging interdisciplinary field of research that uses several technological approaches including stemMesenchymal stem cells (MSCs), a type of adult stem cell, have generated a great amount of interest over

Keywords： mesenchymal stem cells     differentiation     immunomodulation     regenerative medicine    

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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

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Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapiesRemarkable progress has been made in understanding the biology and purpose of stem cells.The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied forthis study discusses current developments in the use of some kinds of MSCs such as adipose-derived stem

Keywords： infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

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The stem cell and tissue engineering research in Chinese ophthalmology

GE Jian, LIU Jingbo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 6-10 doi: 10.1007/s11684-007-0002-x

Abstract: Much has been considerably developed recently in the ophthalmic research of stem cell (SC) and tissue

Keywords： available     observable     neuroregeneration     protection     function reconstruction    

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Title Author Date Type Operation

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Journal Article

The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Journal Article

Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Journal Article

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Journal Article

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Journal Article

Progress, problems and prospects of porcine pluripotent stem cells

Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

Journal Article

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Journal Article

Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic methods

Journal Article

The stem cell and tissue engineering research in Chinese ophthalmology

GE Jian, LIU Jingbo

Journal Article