Resource Type

Journal Article 9

Year

2022 1

2021 1

2018 1

2014 1

2008 2

2007 1

2000 1

1999 1

open ︾

Keywords

case study 2

critical success factors 2

success 2

China 1

Electrostatic hazards 1

O-glycans 1

October 1

adoptive cell therapy 1

alimentary 1

anastomosis 1

availability 1

cancer immunotherapy 1

challenging operation 1

chimeric antigen receptor 1

construction innovation 1

driving factors 1

dunking pancreaticojejunostomy 1

duplex system 1

effect mechanism 1

fault judgement ratio 1

open ︾

Search scope:

排序： Display mode:

Identification of Critical Success Factors for Construction Innovation: From the Perspective of Strategic

Hui Liu,Meng-jun Wang,Miroslaw J. Skibniewski,Ji-shan He,Zhen-sen Zhang

Frontiers of Engineering Management 2014, Volume 1, Issue 2,   Pages 202-209 doi: 10.15302/J-FEM-2014027

Abstract: Therefore, it is significant to explore the Critical Success Factors (CSFs) of construction innovation

Keywords： critical success factors     construction innovation     identification     strategic cooperation    

HTML PDF Collect

Success criteria of large scale construction project based on system thinking

WangJin,Xu Yujie

Strategic Study of CAE 2008, Volume 10, Issue 12,   Pages 79-85

Abstract: And it gives a comprehensive evaluation of the large scale project success from three perspectives of

Keywords： large scale construction project     system thinking     triple bottom line     success criteria    

HTML PDF Collect

cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

Keywords： cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation     O-glycans     adoptive cell therapy    

HTML PDF Collect

The Development in Electrostatic Protection Engineering

Liu Shanghe,Tan Zhiliang,Wu Zhancheng

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 17-24

Abstract: The success and development in electrostatic protection engineering in China are introduced.

Keywords： Electrostatic hazards     effect mechanism     protection engineering     success and development    

HTML PDF Collect

Identifying the driving factors of successful megaproject construction management: Findings from three Chinese cases

Qinghua HE, Junyan XU, Ting WANG, Albert P. C. CHAN

Frontiers of Engineering Management 2021, Volume 8, Issue 1,   Pages 5-16 doi: 10.1007/s42524-019-0058-8

Abstract: Although many studies on megaproject success have been conducted, existing studies on the driving factorsconducting further empirical studies and apply them in future projects to enhance their chances of success

Keywords： megaproject management     driving factors     project success     case study     China    

HTML PDF Collect

Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe graft: experience of 124 cases

YAN Lunan, WEN Tianfu, WANG Wentao, YANG Jiayin, XU Mingqing, CHEN Zheyu, WU Hong

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 130-133 doi: 10.1007/s11684-008-0024-z

Abstract: We ascribe our success to the introduction of microsurgical techniques and the use of fixed operators

Keywords： microsurgical     October     improved     success     transplantation    

HTML PDF Collect

Study of a High-Availability Dual Computer System with Fault Tolerant Architecture

Jin Shiyao,Hu Huaping,Li Hongliang

Strategic Study of CAE 1999, Volume 1, Issue 3,   Pages 46-50

Abstract:

To ensure the high availability, the duplex-computer system with fault tolerance architecture is used in crucial projects. The similarites and differences of the two results from the duplex system have been the key difficulty of this domain. In this paper, there are great progresses in the analysis of availability, the judgement over of two results and the switch over two systems. The techniques have been realized in an important project with significant effect.

Keywords： availability     duplex system     fault judgement ratio     switch success ratio    

HTML PDF Collect

A novel method for reconstruction in laparoscopic pancreaticoduodenectomy: an experience of 13 cases

LU Bangyu, HUANG Yubin, CAI Xiaoyong, HUANG Fei, LU Wenqi, XU Jing, LIU Zujun, YAN Yihe, LI Jianjun, LI Jie

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 369-372 doi: 10.1007/s11684-007-0071-x

Abstract: The reconstruction of alimentary system is a key procedure to ensure success of the whole surgery.

Keywords： alimentary     dunking pancreaticojejunostomy     challenging operation     anastomosis     success    

HTML PDF Collect

Supplier development and its incentives in infrastructure mega-projects: A case study on Hong Kong-Zhuhai-Macao Bridge project

Wei ZENG, Jinwen ZHANG, Hongwei WANG, Hongtao ZHOU

Frontiers of Engineering Management 2018, Volume 5, Issue 1,   Pages 88-97 doi: 10.15302/J-FEM-2018077

Abstract: In this paper the Hong Kong-Zhuhai-Macao Bridge project is taken as a case to analyze supplier development in infrastructure mega-projects. Compared with manufacturing industry, the characteristics of supplier development in infrastructure mega-projects is analyzed in term of development motives, supplier selection, quality management, production mode, owner participation and risks. The critical factors influencing the construction supplier development are identified, which include incentives, collaboration, future market, trust and bilateral communication. Furthermore, focusing on the incentives for the supplier’s product quality and production capacity improvement, decision-making framework models are proposed to design the incentive mechanisms.

Keywords： infrastructure mega-project     supplier development     critical success factors     incentives     case study    

HTML PDF Collect

Title Author Date Type Operation

Identification of Critical Success Factors for Construction Innovation: From the Perspective of Strategic

Hui Liu,Meng-jun Wang,Miroslaw J. Skibniewski,Ji-shan He,Zhen-sen Zhang

Journal Article

Success criteria of large scale construction project based on system thinking

WangJin,Xu Yujie

Journal Article

cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success

Journal Article

The Development in Electrostatic Protection Engineering

Liu Shanghe,Tan Zhiliang,Wu Zhancheng

Journal Article

Identifying the driving factors of successful megaproject construction management: Findings from three Chinese cases

Qinghua HE, Junyan XU, Ting WANG, Albert P. C. CHAN

Journal Article

Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe graft: experience of 124 cases

YAN Lunan, WEN Tianfu, WANG Wentao, YANG Jiayin, XU Mingqing, CHEN Zheyu, WU Hong

Journal Article

Study of a High-Availability Dual Computer System with Fault Tolerant Architecture

Jin Shiyao,Hu Huaping,Li Hongliang

Journal Article

A novel method for reconstruction in laparoscopic pancreaticoduodenectomy: an experience of 13 cases

LU Bangyu, HUANG Yubin, CAI Xiaoyong, HUANG Fei, LU Wenqi, XU Jing, LIU Zujun, YAN Yihe, LI Jianjun, LI Jie

Journal Article

Supplier development and its incentives in infrastructure mega-projects: A case study on Hong Kong-Zhuhai-Macao Bridge project

Wei ZENG, Jinwen ZHANG, Hongwei WANG, Hongtao ZHOU

Journal Article