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Crown ether-thiourea conjugates as ion transporters

Zhixing Zhao, Bailing Tang, Xiaosheng Yan, Xin Wu, Zhao Li, Philip A. Gale, Yun-Bao Jiang

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1, Pages 81-91 doi: 10.1007/s11705-021-2049-7

Abstract: Na , Cl and K are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both Na and Cl across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of K ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for K ions, which led to predominant partitioning of the transporters as the K complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with Na , Cl and K transport capabilities may have potential biological and medicinal applications.

Keywords： ion transport thiourea crown ether symport