Resource Type

Journal Article 41

Conference Videos 1

Year

2023 3

2022 2

2021 6

2020 5

2018 2

2017 1

2016 1

2015 3

2014 4

2013 3

2012 2

2011 2

2010 2

2008 1

2007 1

1999 1

open ︾

Keywords

COVID-19 3

pathogenesis 3

therapeutic 3

DNA 2

Efficacy 2

SARS-CoV-2 2

cancer 2

therapeutic strategy 2

therapeutic target 2

21) 1

Klebsiella pneumoniae 1

ABE 1

ADAR 1

ADCP 1

AML1-ETO 1

Antibody–drug conjugate 1

Antigen 1

B7-H3 1

BCP-ALL 1

open ︾

Search scope:

排序： Display mode:

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 404-418 doi: 10.1007/s11684-014-0379-2

Abstract: functions of circulating miRNAs in cardiovascular system but also inform the development of miRNAs therapeuticthe potential roles of circulating miRNAs in a variety of cardiovascular diseases from biomarkers to therapeutic

Keywords： microRNA     cardiovascular disease     biomarkers     therapeutic target    

HTML PDF Collect

Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 162-172 doi: 10.1007/s11684-015-0382-2

Abstract: induce the development, the activation of brown or beige adipose tissue, which seem to be promising for therapeutic

Keywords： brown adipocyte     beige adipocyte     metabolism     obesity    

HTML PDF Collect

Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 36-42 doi: 10.1007/s11684-010-0020-y

Abstract: Vulnerable atherosclerotic plaque rupture leading to thrombosis is the major cause of acute coronary syndrome (ACS). Studies on the pathophysiologic mechanism of both ACS and plaque stabilizing treatment are driving the development of animal models of vulnerable plaque. In our laboratory, we established animal models of plaque rupture and thrombosis in rabbits and mice that are similar to human plaque rupture. Potential mechanisms involved in plaque vulnerability were studied from the inflammation-immunity, proliferation-apoptosis, oxidative stress and biomechanics aspects. Imaging markers and biomarkers were used to detect vulnerable plaques, including high frequency duplex ultrasound, intravascular ultrasound (IVUS), intravascular ultrasound elastography, magnetic resonance imaging (MRI) and inflammatory markers. Effective gene and drug strategies to treat vulnerable plaques were explored.

Keywords： vulnerable plaque     animal models     mechani-sm     detection     treatment    

HTML PDF Collect

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 117-125 doi: 10.1007/s11684-020-0773-x

Abstract: the insights in the virus, the responses of the host cells, the cytokine release syndrome, and the therapeutic

Keywords： COVID-19     SARS-CoV-2     pathogenesis     evidence-based medicine     control and therapeutic strategies    

HTML PDF Collect

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: of resistance to receptor tyrosine kinase inhibitors, which are the most prevalent class of targeted therapeutic

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

HTML PDF Collect

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 46-56 doi: 10.1007/s11684-015-0375-1

Abstract: important intermediate in these pathophysiological processes and is therefore an important target for therapeuticexpression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeuticThe article concludes with a perspective on the potential of the various therapeutic interventions to

Keywords： oxidative stress     Nrf2     triterpenoids     sickle cell disease     vaso-occlusion     CDDO-Me    

HTML PDF Collect

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Frontiers of Medicine doi: 10.1007/s11684-023-1050-6

Abstract: pancreatic cancer, encompassing its epidemiology, genomic characterization, risk factors, diagnosis, therapeuticthe primary mechanisms underlying treatment resistance in this malignancy, illustrating the latest therapeutic

Keywords： pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy resistance    

HTML PDF Collect

Base editors: development and applications in biomedicine

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 359-387 doi: 10.1007/s11684-023-1013-y

Abstract: summarize their applications in the biomedical field, and discuss future perspectives and challenges for therapeutic

Keywords： base editing     CBE     ABE     ADAR     DdCBE     disease model     therapeutic application    

HTML PDF Collect

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract: We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

HTML PDF Collect

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract:

Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

HTML PDF Collect

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 255-263 doi: 10.1007/s11684-012-0227-1

Abstract: We aimed to assess the therapeutic effect of UDCA on Chinese patients with PBC.

Keywords： primary biliary cirrhosis     ursodeoxycholic acid     Chinese     biochemical response     therapeutic efficacy    

HTML PDF Collect

Early diagnosis and therapeutic choice of

Jing LI, Ying FU, Ji-Yao WANG, Chuan-Tao TU, Xi-Zhong SHEN, Lei LI, Wei JIANG

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 308-316 doi: 10.1007/s11684-010-0103-9

Abstract: retained catheter, and aspiration plus antibiotics flushing and retained catheter), and corresponding therapeutic

Keywords： liver abscess     Klebsiella pneumoniae     computed tomography     therapy    

HTML PDF Collect

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 723-735 doi: 10.1007/s11684-021-0905-y

Abstract: Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.

Keywords： amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

HTML PDF Collect

Therapeutic application of hydrogen sulfide donors: the potential and challenges

Dan Wu,Qingxun Hu,Yizhun Zhu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 18-27 doi: 10.1007/s11684-015-0427-6

Abstract:

Hydrogen sulfide (H2S), a colorless gas smelling of rotten egg, has long been considered a toxic gas and environment hazard. However, evidences show that H2S plays a great role in many physiological and pathological activities, and it exhibits different effects when applied at various doses. In this review, we summarize the chemistry and biomedical applications of H2S-releasing compounds, including inorganic salts, phosphorodithioate derivatives, derivatives of Allium sativum extracts, derivatives of thioaminoacids, and derivatives of anti-inflammatory drugs.

Keywords： hydrogen sulfide     cardiovascular     cancer     hypertension    

HTML PDF Collect

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 275-286 doi: 10.1007/s11705-011-1203-z

Abstract: Polymer-based conjugates are an interesting option and challenge for the design of nano-sized drug-delivery systems, as they require advanced conjugation chemistry and precise engineering. In the case of nucleic acid therapy, non-viral carriers face several biological barriers during the delivery process, namely 1) protection of the cargo from extracellular degradation, 2) avoidance of non-specific interactions with non-targeted tissues, 3) efficient entry into the target cells, 4) intracellular trafficking to the site of action and 5) cargo release. To take on these obstacles, multifunctional conjugates can act as “smart polymers” with microenvironment-sensing dynamics to facilitate the separate delivery steps. Synthesis of defined polymer architectures with precise functionalization enables structure-activity relationships to be investigated and the integration of key functions for efficient delivery. Thus bioresponsive polymer conjugates, which are equipped with molecular devices responding to the certain microenvironments within the delivery pathway (e.g. pH, redox potential, enzymes) can be assembled. This review focuses on the modular engineering and conjugation of multifunctional polymeric structures for the utilization as “tailor-made” nucleic acid carriers.

Keywords： conjugate     DNA     gene transfer     polymer     RNA     targeting    

HTML PDF Collect

Title Author Date Type Operation

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Journal Article

Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Journal Article

Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

Journal Article

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Journal Article

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Journal Article

Base editors: development and applications in biomedicine

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Journal Article

Early diagnosis and therapeutic choice of

Jing LI, Ying FU, Ji-Yao WANG, Chuan-Tao TU, Xi-Zhong SHEN, Lei LI, Wei JIANG

Journal Article

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic

Journal Article

Therapeutic application of hydrogen sulfide donors: the potential and challenges

Dan Wu,Qingxun Hu,Yizhun Zhu

Journal Article

Invading target cells: multifunctional polymer conjugates as therapeutic nucleic acid carriers

Ulrich L?CHELT, Ernst WAGNER

Journal Article