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Transcriptome resources and genome-wide marker development for Japanese larch (
Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG
Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1, Pages 77-84 doi: 10.15302/J-FASE-2014010
Keywords: Larix transcriptome age wood formation somatic embryogenesis molecular marker
Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 322-330 doi: 10.1007/s11684-015-0408-9
This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular
Keywords: TCGA whole-transcriptome sequencing HCC liver cancer
Frontiers of Medicine doi: 10.1007/s11684-023-1029-3
Keywords: tumor prognosis molecular Microbiome subsets determine center analysis microbiome transcriptome data
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,
Hongyuan ZHAO, Shanshan ZHANG, Feibing WANG, Ning ZHAO, Shaozhen HE, Qingchang LIU, Hong ZHAI
Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2, Pages 214-225 doi: 10.15302/J-FASE-2018219
Keywords: anthocyanin gene expression mutant purple-fleshed sweet potato transcriptome
Lijuan Hu,Zhirui Lin,Yanheng Wu,Juqin Dong,Bo Zhao,Yanbing Cheng,Peiyu Huang,Lihua Xu,Tianliang Xia,Dan Xiong,Hongbo Wang,Manzhi Li,Ling Guo,Elliott Kieff,Yixin Zeng,Qian Zhong,Musheng Zeng
Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 61-75 doi: 10.1007/s11684-016-0436-0
Keywords: Epstein-Barr virus paired-end transcriptome sequencing latency genes lytic genes nasopharyngeal carcinoma
Exploring the cancer genome in the era of next-generation sequencing
Hui Dong, Shengyue Wang
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 48-55 doi: 10.1007/s11684-012-0182-x
Keywords: next-generation sequencing cancer genome whole genome sequencing exome transcriptome
Nan Ding,Jiafei Xi,Yanming Li,Xiaoyan Xie,Jian Shi,Zhaojun Zhang,Yanhua Li,Fang Fang,Sihan Wang,Wen Yue,Xuetao Pei,Xiangdong Fang
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 297-310 doi: 10.1007/s11684-016-0452-0
Keywords: erythroid differentiation hematopoietic stem cell RNA-seq miRNA lncRNA
Transcriptome analysis of wheat grain using RNA-Seq
Liu WEI,Zhihui WU,Yufeng ZHANG,Dandan GUO,Yuzhou XU,Weixia CHEN,Haiying ZHOU,Mingshan YOU,Baoyun LI
Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3, Pages 214-222 doi: 10.15302/J-FASE-2014024
Keywords: transcriptome analysis wheat grain differentially expressed genes enrichment analysis
Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN
Frontiers of Agricultural Science and Engineering Pages 215-230 doi: 10.15302/J-FASE-2021382
Keywords: harvest season metabolites tea shoots transcriptomics untargeted metabolomics
Jian Yang, Lili Zhao, Sheng Yi, Fei Ding, Yumin Yang, Yan Liu, Yongjun Wang, Mei Liu, Chengbin Xue, Lian Xu, Leilei Gong, Xinghui Wang, Yu Zhang, Bin Yu, Guo-li Ming, Xiaosong Gu
Engineering 2021, Volume 7, Issue 11, Pages 1592-1602 doi: 10.1016/j.eng.2021.10.001
The molecular network features of spinal cord development that are integral to tissue engineering remain poorly understood in placental mammals, especially in terms of their relationships with vital biological processes such as regeneration. Here, using a large-scale temporal transcriptomic analysis of rat spinal cord from the embryonic stage to adulthood, we show that fluctuating RNA expression levels reflect highly active transcriptional regulation, which may initiate spinal cord patterning. We also demonstrate that microRNAs (miRNAs) and transcriptional factors exhibit a mosaic profile based on their expression patterns, while differential alternative splicing events reveal that alternative splicing may be a driving force for the development of the node of Ranvier. Our study also supports the existence of a negative correlation between innate immunity and intrinsic growth capacity. Epigenetic modifications appear to perform their respective regulatory functions at different stages of development, while guanine nucleotide-binding protein (G protein)-coupled receptors (including olfactory receptors (ORs)) may perform pleiotropic roles in axonal growth. This study provides a valuable resource for investigating spinal cord development and complements the increasing number of single-cell datasets. These findings also provide a genetic basis for the development of novel tissue engineering strategies.
Keywords: Development Gene expression pattern Innate immunity Spinal cord Transcriptome
Polar Animal Genetic Resources: Current Situation and Development Strategies
Chen Songlin, Xu Wenteng, Chen Zhangfan
Strategic Study of CAE 2019, Volume 21, Issue 6, Pages 39-47 doi: 10.15302/J-SSCAE-2019.06.007
Keywords: polar animal genome transcriptome genetic resources
Haiyan WANG, Qiaoxia ZHANG, Lilin YIN, Xiangdong LIU, Shuhong ZHAO, Mengjin ZHU, Changchun LI
Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 342-352 doi: 10.15302/J-FASE-2017162
Keywords: neutrophil peripheral blood pig poly I:C transcriptome
Yan Zhang, Shuting Wang, He Xia, Jing Guo, Kangxin He, Chenjie Huang, Rui Luo, Yanfei Chen, Kaijin Xu, Hainv Gao, Jifang Sheng, Lanjuan Li
Engineering 2022, Volume 17, Issue 10, Pages 161-169 doi: 10.1016/j.eng.2021.05.009
Understanding the immunological characteristics of monocytes—including the characteristics associated with fibrosis—in severe coronavirus disease 2019 (COVID-19) is crucial for understanding the pathogenic mechanism of the disease and preventing disease severity. In this study, we performed single-cell transcriptomic sequencing of peripheral blood samples collected from six healthy controls and 14 COVID-19 samples including severe, moderate, and convalescent samples from three severely/critically ill and four moderately ill patients. We found that the monocytes were strongly remodeled in the severely/critically ill patients with COVID-19, with an increased proportion of monocytes and seriously reduced diversity. In addition, we discovered two novel severe-disease-specific monocyte subsets: Mono 0 and Mono 5. These subsets expressed amphiregulin (AREG), epiregulin (EREG), and cytokine interleukin-18 (IL-18) gene, exhibited an enriched erythroblastic leukemia viral oncogene homolog (ErbB) signaling pathway, and appeared to exhibit pro-fibrogenic and pro-inflammation characteristics. We also found metabolic changes in Mono 0 and Mono 5, including increased glycolysis/gluconeogenesis and an increased hypoxia inducible factor-1 (HIF-1) signaling pathway. Notably, one pre-severe sample displayed a monocyte atlas similar to that of the severe/critical samples. In conclusion, our study discovered two novel severe-disease-specific monocyte subsets as potential predictors and therapeutic targets for severe COVID-19. Overall, this study provides potential predictors for severe disease and therapeutic targets for COVID-19 and thus provides a resource for further studies on COVID-19.
Keywords: COVID-19 Severe infection Critically ill Monocytes Fibrosis
Shuang Yu, Yanqiang Ding, Xuejie Wang, Siu Kin Ng, Siting Cao, Weixin Liu, Zhuming Guo, Yubin Xie, Shubin Hong, Lixia Xu, Xiaoxing Li, Jie Li, Weiming Lv, Sui Peng, Yanbing Li, Joseph J.Y. Sung, Jun Yu, Haipeng Xiao
Engineering 2023, Volume 28, Issue 9, Pages 179-192 doi: 10.1016/j.eng.2023.01.007
Keywords: Papillary thyroid cancer Benign thyroid nodule Bacteria Transcriptome Hashimoto's thyroiditis
Title Author Date Type Operation
Transcriptome resources and genome-wide marker development for Japanese larch (
Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG
Journal Article
TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways
Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng
Journal Article
clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome
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METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN
Journal Article
Comparative transcriptome analysis of purple-fleshed sweet potato provides insights into the molecular
Hongyuan ZHAO, Shanshan ZHANG, Feibing WANG, Ning ZHAO, Shaozhen HE, Qingchang LIU, Hong ZHAI
Journal Article
Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome
Lijuan Hu,Zhirui Lin,Yanheng Wu,Juqin Dong,Bo Zhao,Yanbing Cheng,Peiyu Huang,Lihua Xu,Tianliang Xia,Dan Xiong,Hongbo Wang,Manzhi Li,Ling Guo,Elliott Kieff,Yixin Zeng,Qian Zhong,Musheng Zeng
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Exploring the cancer genome in the era of next-generation sequencing
Hui Dong, Shengyue Wang
Journal Article
Global transcriptome analysis for identification of interactions between coding and noncoding RNAs during
Nan Ding,Jiafei Xi,Yanming Li,Xiaoyan Xie,Jian Shi,Zhaojun Zhang,Yanhua Li,Fang Fang,Sihan Wang,Wen Yue,Xuetao Pei,Xiangdong Fang
Journal Article
Transcriptome analysis of wheat grain using RNA-Seq
Liu WEI,Zhihui WU,Yufeng ZHANG,Dandan GUO,Yuzhou XU,Weixia CHEN,Haiying ZHOU,Mingshan YOU,Baoyun LI
Journal Article
METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN
Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN
Journal Article
Developmental Temporal Patterns and Molecular Network Features in the Transcriptome of Rat Spinal Cord
Jian Yang, Lili Zhao, Sheng Yi, Fei Ding, Yumin Yang, Yan Liu, Yongjun Wang, Mei Liu, Chengbin Xue, Lian Xu, Leilei Gong, Xinghui Wang, Yu Zhang, Bin Yu, Guo-li Ming, Xiaosong Gu
Journal Article
Polar Animal Genetic Resources: Current Situation and Development Strategies
Chen Songlin, Xu Wenteng, Chen Zhangfan
Journal Article
Transcriptomic basis of neutrophil ratio variation induced by poly I:C stimulation in porcine peripheral blood
Haiyan WANG, Qiaoxia ZHANG, Lilin YIN, Xiangdong LIU, Shuhong ZHAO, Mengjin ZHU, Changchun LI
Journal Article
Monocytes Associated with Severe COVID-19 in the PBMCs of Severely Infected Patients Through Single-Cell Transcriptome
Yan Zhang, Shuting Wang, He Xia, Jing Guo, Kangxin He, Chenjie Huang, Rui Luo, Yanfei Chen, Kaijin Xu, Hainv Gao, Jifang Sheng, Lanjuan Li
Journal Article
Intratumoral Bacteria Dysbiosis Is Associated with Human Papillary Thyroid Cancer and Correlated with Oncogenic Signaling Pathways
Shuang Yu, Yanqiang Ding, Xuejie Wang, Siu Kin Ng, Siting Cao, Weixin Liu, Zhuming Guo, Yubin Xie, Shubin Hong, Lixia Xu, Xiaoxing Li, Jie Li, Weiming Lv, Sui Peng, Yanbing Li, Joseph J.Y. Sung, Jun Yu, Haipeng Xiao
Journal Article