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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 388-397 doi: 10.1007/s11684-018-0624-1

Abstract: Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloidleukemia (AML).) AML.) AML.) AML cell line and mouse model.

Keywords: AML1–ETO     c-KIT     homoharringtonine     oridonin     t(8     21) AML     synergistic effect    

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentBoth human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis-ETO to induce AML in vivo.We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting theRecently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may

Keywords: AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy withTwo leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21) AML clinical prognosis.In this study, 85 patients with t(8;21) AML were enrolled.) AML.

Keywords: t(8     21)(q22     q22) AML     CD34+CD117dim/ CD34+CD117bri cell population    

Orienting the Forest Remote Sensing of the 21st Century in China

Zhao Xianwen

Strategic Study of CAE 1999, Volume 1, Issue 3,   Pages 16-21

Abstract:

In the light of the mentioned above, the forest remote sensing perspective of the 21 st century

Keywords: forestry     remote sensing     developing of sustainable forestry     forestry towards the 21 st century    

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolismMoreover, FGF21 also plays important roles in some physiological processes, such as fasting and feedingClinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21This article concentrates on recent advances in our understanding of FGF21.

Keywords: FGF21     metabolism     pharmacology     physiology     clinical relevance    

An Opinion on the Development of Oil and Gas Industry in the 21st Century

Chen Junwu

Strategic Study of CAE 2000, Volume 2, Issue 4,   Pages 21-24

Abstract:

The speed of international social-economic development closely depends upon the growth of world energy consumption, which in turn has to meet the stringent environmental protection policy that controls the total amount of greenhouse gas released to the atmosphere in the burning of fuel. In order to achieve the sustainable development of all nations, it is advisable to give an outlook to the future situation of world oil and gas industry as the representatives of the non-regenerable energy resources. This paper presents an opinion on the future development of oil and gas industry based on limited data published in literature together with controversial forecasts by different authors and covers four subjects: (1) the demand and supply of oil and gas in the new century; (2) the specifications of oil products to meet the environmental regulations; (3) the role of unconventional oil in the energy industry and (4) the brilliant future of natural gas.

Keywords: 21st centurey     petroleum     natural gas     oil and gas industry    

Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Strategic Study of CAE 2002, Volume 4, Issue 4,   Pages 1-11

Abstract:

This article, from the angle of management, reviews the world history over the past century, studies the prospective progress in the new century, and discusses ways for promoting world peace and cooperation and realizing common development.

Keywords: 21st century     progress in science and technology     human's living and survival    

Digital manufacturing—the development direction of the manufacturing technology in the 21st century

XIONG You-lun, YIN Zhou-ping

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 2,   Pages 125-130 doi: 10.1007/s11465-006-0021-3

Abstract: After introducing the concepts of digital manufacturing technology, the discipline framework of digital manufacturing is presented in the paper by discussing its basic concept, theory foundation, key technology and scientific problems in detail. As the core of the advanced manufacturing technology, digital manufacturing is gradually becoming the main manufacturing technology of the twenty-first century. Firstly, the main features of digital manufacturing are indicated and its key supporting technologies are investigated by grouping them into four levels related to product development, numerical control, production management, and enterprise collaboration, respectively. Moreover, the existing problems in the research on the multi-discipline theory foundation of digital manufacturing such as manufacturing informatics, computational manufacturing, and manufacturing intelligence, are also indicated. Then, the core scientific problems of digital manufacturing are discussed in depth, which focuses on digitization of manufacturing information, modeling of manufacturing constraints, high-speed and high-precision numerical control theory, and Internet-based collaboration and integration. Lastly, the development trends and application perspectives of digital manufacturing are concluded.

Keywords: development     foundation     multi-discipline     scientific     supporting    

The Challenge of Computing and Information Technology in the 21st Century

Wm. A. Wulf

Strategic Study of CAE 2000, Volume 2, Issue 10,   Pages 9-12

How diplomacy saved the COP21 Paris Climate Conference, but now, can we save ourselves?

D. Nathaniel MULCAHY, David L. MULCAHY

Frontiers in Energy 2018, Volume 12, Issue 3,   Pages 344-352 doi: 10.1007/s11708-017-0498-y

Abstract: The 2015 COP21 Paris accord was a masterful, perhaps even world-saving, diplomatic advance toward makingsome scientific truths, written specifically to be overlooked, were presented in order to prepare COP21

Keywords: COP21     Paris     climate     agreement     offsets     mitigation     IPCC    

Development Trends of Chemical and Biological Weapons and Defense Technology in the 21st Century

Chen Jisheng

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 25-28

Abstract: An realized risk of chemical and biological threat still remain in the 21st century.

Keywords: chemical and biological weapon     chemical and biological defense     medical protection     chemical and biological agents spectrum    

Ultrasonic Motor Techniques for 21st Century

Zhao Chunsheng

Strategic Study of CAE 2002, Volume 4, Issue 2,   Pages 86-91

Abstract: Secondly, the author predicts that a great and growing market for the motors will be found in the 21stFinally, the trend of the development of the motor in the 21st century is pointed out.

Keywords: ultrasonic motor     piezoelectric ceramics     friction materials    

Sustainable intensification of agriculture is key to feeding Africa in the 21st century

Shenggen FAN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 4,   Pages 366-370 doi: 10.15302/J-FASE-2020342

Abstract:

Africa in facing numerous challenges in the 21st century in feeding its rapidly increasing population

Keywords: Africa     sustainable intensification     Agricultural Green Development     climate change     malnutrition    

Title Author Date Type Operation

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

Orienting the Forest Remote Sensing of the 21st Century in China

Zhao Xianwen

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

An Opinion on the Development of Oil and Gas Industry in the 21st Century

Chen Junwu

Journal Article

Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Journal Article

Digital manufacturing—the development direction of the manufacturing technology in the 21st century

XIONG You-lun, YIN Zhou-ping

Journal Article

The Challenge of Computing and Information Technology in the 21st Century

Wm. A. Wulf

Journal Article

Seminar on the Current Situation and Development Trend of New Materials in the 21st Century

Journal Article

How diplomacy saved the COP21 Paris Climate Conference, but now, can we save ourselves?

D. Nathaniel MULCAHY, David L. MULCAHY

Journal Article

Summary of the Symposium on the Current Situation and Development Trend of New Materials in the 21st

null

Journal Article

Development Trends of Chemical and Biological Weapons and Defense Technology in the 21st Century

Chen Jisheng

Journal Article

Ultrasonic Motor Techniques for 21st Century

Zhao Chunsheng

Journal Article

Sustainable intensification of agriculture is key to feeding Africa in the 21st century

Shenggen FAN

Journal Article