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Gut microbial balance and liver transplantation: alteration, management, and prediction

Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 123-129 doi: 10.1007/s11684-017-0563-2

Abstract: Importantly, the resulting alteration of gut microbiota aggravates graft dysfunctions during the processThis article reviews the research progress for gut microbial alterations and liver transplantation.Especially, this work also evaluates research on the management of gut microbial alteration and the predictionIn addition, we propose possible directions for research on gut microbial alteration during liver transplantation

Keywords: gut microbial balance     liver transplantation     ischemia–reperfusion     acute rejection    

Integrated analysis of gut microbiome and host immune responses in COVID-19

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 263-275 doi: 10.1007/s11684-022-0921-6

Abstract: Emerging evidence indicates that the gut microbiome contributes to the host immune response to infectiousHere, to explore the role of the gut microbiome in the host immune responses in COVID-19, we conductedWe found that the diversity of the gut microbiome was reduced in severe/critical COVID-19 cases comparedWe identified the abundance of some gut microbes altered post-SARS-CoV-2 infection and related to diseasea correlation map between clinical features of COVID-19 and 16 severity-related gut microbe, including

Keywords: COVID-19     SARS-COV-2     gut microbiome     immune response    

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: disease because of the intricate role of gut microbiota in maintaining human health and disease formationMoreover, gut microbiota is even regarded as a “metabolic organ” that play complementary roles to thatAs a result, gut microbiota have been emerging as a novel therapeutic target for NAFLD by manipulatingIn this review, we summarized the most recent advances in gut microbiota-mediated mechanisms, as wellas gut microbiota-targeted therapies on NAFLD.

Keywords: gut microbiota     NAFLD     obesity     insulin resistance     bile acids     probiotic    

Calorie restriction and its impact on gut microbial composition and global metabolism

Xiaojiao Zheng, Shouli Wang, Wei Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 634-644 doi: 10.1007/s11684-018-0670-8

Abstract: In the present review, we focus on the general effect of CR on gut microbiota composition and globalAnalyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites wereThe observed phenotypes and the further verification of the direct link between gut microbiota and metabolomeThus, improved gut microbiota composition and metabolome are potential biomarkers for determining the

Keywords: caloric restriction     gut microbiota     metabolome    

ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Frontiers of Medicine   Pages 972-992 doi: 10.1007/s11684-023-0990-1

Abstract: Owing to the increasing incidence and prevalence of inflammatory bowel disease (IBD) worldwide, effective and safe treatments for IBD are urgently needed. Hydrogen sulfide (H2S) is an endogenous gasotransmitter and plays an important role in inflammation. To date, H2S-releasing agents are viewed as potential anti-inflammatory drugs. The slow-releasing H2S donor 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT-OH), known as a potent therapeutic with chemopreventive and cytoprotective properties, has received attention recently. Here, we reported its anti-inflammatory effects on dextran sodium sulfate (DSS)-induced acute (7 days) and chronic (30 days) colitis. We found that ADT-OH effectively reduced the DSS-colitis clinical score and reversed the inflammation-induced shortening of colon length. Moreover, ADT-OH reduced intestinal inflammation by suppressing the nuclear factor kappa-B pathway. In vivo and in vitro results showed that ADT-OH decreased intestinal permeability by increasing the expression of zonula occludens-1 and occludin and blocking increases in myosin II regulatory light chain phosphorylation and epithelial myosin light chain kinase protein expression levels. In addition, ADT-OH restored intestinal microbiota dysbiosis characterized by the significantly increased abundance of Muribaculaceae and Alistipes and markedly decreased abundance of Helicobacter, Mucispirillum, Parasutterella, and Desulfovibrio. Transplanting ADT-OH-modulated microbiota can alleviate DSS-induced colitis and negatively regulate the expression of local and systemic proinflammatory cytokines. Collectively, ADT-OH is safe without any short-term (5 days) or long-term (30 days) toxicological adverse effects and can be used as an alternative therapeutic agent for IBD treatment.

Keywords: inflammatory bowel disease     ADT-OH     intestinal permeability     gut microbiota    

From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 191-200 doi: 10.1007/s11684-013-0258-2

Abstract:

Increasing evidence suggests that the gut may influence the host’s metabolism and ultimatelyWe review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgery, and discuss the potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changes, altered gut cells, and gut hormone modulation.

Keywords: gastric bypass     T2DM     gut    

Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Engineering doi: 10.1016/j.eng.2022.10.010

Abstract: Through the metagenomic sequencing of stool samples, we found that PTH administration restored the gutIn addition, PTH restored the gut barrier function in mice with steatohepatitis, as evidenced by reducedWe further confirmed that an intact gut microbiota is necessary for PTH to exhibit anti-steatohepatitisIn conclusion, PTH protects against steatohepatitis development by modulating the gut microbiota and

Keywords: Pien Tze Huang     Non-alcoholic steatohepatitis     Gut barrier function     Gut microbiota    

Biodegradation of waste refrigerator polyurethane by mealworms

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1638-8

Abstract:

● Waste refrigerator polyurethane (WRPU) was ingested and biodegraded by mealworms.

Keywords: Waste refrigerator polyurethane     Mealworms     Biodegradation     Carbon balance     Gut microorganism    

Modulation of Gut Microbiota in Pathological States

Yulan Wang, Baohong Wang, Junfang Wu, Xiangyang Jiang, Huiru Tang, Ole H. Nielsen

Engineering 2017, Volume 3, Issue 1,   Pages 83-89 doi: 10.1016/J.ENG.2017.01.013

Abstract: Our gut microbiota evolves with us and plays a pivotal role in human health and disease.The gut microbiota may be linked to malignancies such as gastric cancer and colorectal cancer., the aim of this review is to provide the reader with an updated overview of the importance of the gutmicrobiota for human health and the potential to manipulate gut microbial composition for purposes suchThe concept of altering the gut community by microbial intervention in an effort to improve health is

Keywords: Gut microbes     Diseases     Microbial modulation    

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 239-248 doi: 10.1007/s11684-018-0617-0

Abstract:

The gut microbiota is mainly composed of a diverse population of commensal bacterial species and playsThe influence of the gut microbiota on solid organ transplantation has recently been recognized.bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gutFurthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeuticGiven that current research on the gut microbiota has become increasingly sophisticated and comprehensive

Keywords: gut microbiota     small bowel transplantation     acute rejection     chronic rejection     mucosal immunity     biomarker    

The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Engineering 2017, Volume 3, Issue 1,   Pages 110-114 doi: 10.1016/J.ENG.2017.01.017

Abstract:

In recent decades, diseases concerning the gut microbiota have presented some of the most seriousExtensive epidemiological studies have revealed that there is a strong link between the gut microbiotaTo be specific, the gut milieu may play an important role in systemic inflammation, endotoxemia, andRelevant animal studies involving gut microbiota manipulations, combined with observational studies onStudies of the composition and function of the gut microbiota could shed some light on understanding

Keywords: Gut microbiota     Dysbiosis     Tumorigenesis     Hepatocellular carcinoma     Nonalcoholic fatty liver disease    

Treating Chronic Diseases by Regulating the Gut Microbiota

Bin Hong, Jian-Dong Jiang

Engineering 2022, Volume 18, Issue 11,   Pages 17-20 doi: 10.1016/j.eng.2021.08.015

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Intestinal homeostasis is maintained by specialized host cells and the gut microbiota.Here, we aim to demonstrate that intestinal Axin1 determines gut homeostasis and host response to inflammationThese data suggest non-colitogenic effects driven by the gut microbiome.

Keywords: Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia muciniphila     Wnt    

Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 307-321 doi: 10.1007/s11684-022-0927-0

Abstract: Studies have shown that the gut microbiota is essential for the interaction between immune checkpointantibiotics, with an in-depth discussion about the mechanisms and therapeutic potential of modulating gut

Keywords: tumor immunotherapy     immune checkpoint inhibitor     antibiotics     gut microbiota     drug–drug interaction    

Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders Review

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Engineering 2020, Volume 6, Issue 4,   Pages 415-423 doi: 10.1016/j.eng.2019.07.026

Abstract:

It is well known that the gut microbiota plays an extremely important role in modulating host physiologicalIn recent years, accumulated evidence has revealed that the gut microbiota can regulate the functionsof the central nervous system (CNS) through the gut–brain axis, which provides a novel insightinto the interactions between the gut and brain.gut microbiota dysbiosis.

Keywords: Gut microbiota     Gut–brain axis     Neurological disorders     Intervention strategies    

Title Author Date Type Operation

Gut microbial balance and liver transplantation: alteration, management, and prediction

Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng

Journal Article

Integrated analysis of gut microbiome and host immune responses in COVID-19

Journal Article

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Journal Article

Calorie restriction and its impact on gut microbial composition and global metabolism

Xiaojiao Zheng, Shouli Wang, Wei Jia

Journal Article

ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Journal Article

From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Journal Article

Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Journal Article

Biodegradation of waste refrigerator polyurethane by mealworms

Journal Article

Modulation of Gut Microbiota in Pathological States

Yulan Wang, Baohong Wang, Junfang Wu, Xiangyang Jiang, Huiru Tang, Ole H. Nielsen

Journal Article

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Journal Article

The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Journal Article

Treating Chronic Diseases by Regulating the Gut Microbiota

Bin Hong, Jian-Dong Jiang

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Journal Article

Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders

Wanqiang Wu, Qingmin Kong, Peijun Tian, Qixiao Zhai, Gang Wang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Yuan Kun Lee, Wei Chen

Journal Article