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The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 33-41 doi: 10.1007/s11684-013-0301-3

Abstract:

Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC).Hypoxia stabilizes transcription factor, hypoxia-inducible factor (HIF), to activate gene transcriptionExpression of HIF is closely associated with metastasis and poor prognosis in HCC.Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when usedThis review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular

Keywords： hypoxia     hepatocellular carcinoma (HCC)     metastasis     hypoxia-inducible factor (HIF)    

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Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: to explore the effects and signaling pathway of ultraviolet-B (UVB) irradiation on the expression of hypoxia-induciblefactor 1α (HIF-1α) and transferrin receptor (TfR).HIF-1α protein was measured by Western blot method.Expressions of epidermal growth factor receptor (EGFR), phosphor-EGF-R and TfR after UVB irradiationPI3K inhibitors, LY294002 and wortmannin, inhibited HIF-1?
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Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 303-308 doi: 10.1007/s11684-009-0060-3

Abstract: The effects of hypoxia on the invasion and the related protein expression of Hela cells and the roleof hypoxia inducible factor-1α (HIF-1α) were investigated.-1α-shRNA plasmid-transfected Hela cells), and were cultured under hypoxia (1% O) and normoxia forwere detected in the H and H groups under hypoxia for 48h.of HIF-1α was detectable.

Keywords： hypoxia     actin     β     -catenin     E-cadherin     invasion    

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Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion

Geqing XIA, Chaoying WU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 216-219 doi: 10.1007/s11684-009-0028-3

Abstract: The purpose of this study was to investigate the expression of inducible nitric oxide synthase in trophoblastsin early medical abortion, and study the relationship of medical abortion through mifepristone and inducible

Keywords： mifepristone     inducible nitric oxide synthase     early pregnancy     placental immunity    

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Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4

Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 880-888 doi: 10.1007/s11705-019-1864-6

Abstract: It was postulated that the Azo-CA4 might be degraded under hypoxia, resulting in the decrease of itsstaining study indicates that Azo-CA4 loses the potency of switching off microtubule dynamics under hypoxiaTherefore, the cytotoxicity of Azo-CA4 is compromised under hypoxia.

Keywords： hypoxia     microtubule inhibitor     drug delivery     azo-combretastatin A4     photo-responsive    

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Effects of hypoxia on mRNA expression of housekeeping genes in rat brain tissue and primary cultured

YANG Yingzhong, MA Lan, GE Rili, FAN Wenhong, ZHU Lingling, ZHAO Tong, WU Yan, FAN Ming

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 239-243 doi: 10.1007/s11684-008-0045-7

Abstract: Rats subjected to acute hypoxia for 2 hours were used for tissue detection.In both experiments, expression levels of 28S rRNA and 18S rRNA were constant, independent of hypoxia18S rRNA and 28S rRNA are reliable internal controls for comparative analyses of transcription under hypoxia

Keywords： Glyceraldehyde-3-phosphate dehydrogenase     comparative     constant     unfavorable     independent    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract: Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 6,   Pages 1015-1024 doi: 10.1007/s11783-014-0670-0

Abstract: land area types with different levels of productivity, they introduced the concept of an equivalence factorSecondly, China’s equivalence factor for 6 land area types was calculated based on NPP: arable land andbuilt-up land has an equivalence factor of 1.71, forest and fossil energy land has a factor of 1.41,pasture has a factor of 0.44 and water/fishery 0.35; Finally, the equivalence factor of 6 land areaThe NPP of each ecosystem type varies along with the equivalence factor in different provinces.

Keywords： ecological footprint     equivalence factor     net primary production     biological capacity     land types    

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LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 7,   Pages 871-881 doi: 10.1007/s11709-022-0863-8

Abstract: failure criteria of practical soil mass are very complex, and have significant influence on the safety factorto determine the failure criterion, the limit equilibrium method can be used to calculate the safety factorAnalysis of results of the safety factor of two three-dimensional homogeneous slopes shows that the maximum

Keywords： slope stability     safety factor     failure criterion     least square support vector machine    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3IMechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 877-894 doi: 10.1007/s11709-021-0756-2

Abstract: Many bridge design specifications consider multi-lane factors (MLFs) a critical component of the traffic load model. Measured multi-lane traffic data generally exhibit significant lane disparities in traffic loads over multiple lanes. However, these disparities are not considered in current specifications. To address this drawback, a multi-coefficient MLF model was developed based on an improved probabilistic statistical approach that considers the presence of multiple trucks. The proposed MLF model and approach were calibrated and demonstrated through an example site. The model sensitivity analysis demonstrated the significant influence of lane disparity of truck traffic volume and truck weight distribution on the MLF. Using the proposed approach, the experimental site study yielded MLFs comparable with those directly calculated using traffic load effects. The exclusion of overloaded trucks caused the proposed approach, existing design specifications, and conventional approach of ignoring lane load disparity to generate comparable MLFs, while the MLFs based on the proposed approach were the most comprehensive. The inclusion of overloaded trucks caused the conventional approach and design specifications to overestimate the MLFs significantly. Finally, the benefits of the research results to bridge practitioners were discussed.

Keywords： bridges     multi-lane factor     traffic load     lane load disparity     multi-truck presence     weigh-in-motion    

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Numerical investigation of the influence of kinetics and shape factor on barium sulfate precipitation

Zheng WANG, Zai-Sha MAO, Chao YANG, Qinghua ZHANG, Jingcai CHENG

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 272-281 doi: 10.1007/s11705-009-0023-x

Abstract: The effect of kinetics and shape factor on barium sulfate precipitation in a continuous stirred tankThe simulation results show that the value of shape factor used in the model affected greatly the meanIt is important to investigate the relationship of the shape factor with the precipitator type and other

Keywords： stirred tank     numerical simulation     precipitation     shape factor     crystal kinetics    

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The formation mechanism and the influence factor of residual stress in machining

Zhaoxu QI,Bin LI,Liangshan XIONG

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 3,   Pages 265-269 doi: 10.1007/s11465-014-0311-0

Abstract: An important conclusion is drawn that the accumulated plastic strain is the main factor which determines

Keywords： residual stress     analytical model     strain     plastic     cutting parameter    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 403-409 doi: 10.1007/s11684-017-0522-y

Abstract:

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation

Keywords： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Title Author Date Type Operation

The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K

LI Yanhua, BI Zhigang

Journal Article

Effects of hypoxia inducible factor-1alpha siRNA on the invasion of human Hela cells and expression of

Bin YANG MS , Xianglin YUAN , Yanmei ZOU , Qingsong XI , Guoxian LONG , Qiang FU , Guangyuan HU MM ,

Journal Article

Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion

Geqing XIA, Chaoying WU

Journal Article

Hypoxia-induced activity loss of a photo-responsive microtubule inhibitor azobenzene combretastatin A4

Yang An, Chao Chen, Jundong Zhu, Pankaj Dwivedi, Yanjun Zhao, Zheng Wang

Journal Article

Effects of hypoxia on mRNA expression of housekeeping genes in rat brain tissue and primary cultured

YANG Yingzhong, MA Lan, GE Rili, FAN Wenhong, ZHU Lingling, ZHAO Tong, WU Yan, FAN Ming

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

Journal Article

LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

Journal Article

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

Journal Article

Numerical investigation of the influence of kinetics and shape factor on barium sulfate precipitation

Zheng WANG, Zai-Sha MAO, Chao YANG, Qinghua ZHANG, Jingcai CHENG

Journal Article

The formation mechanism and the influence factor of residual stress in machining

Zhaoxu QI,Bin LI,Liangshan XIONG

Journal Article

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article