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TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 322-330 doi: 10.1007/s11684-015-0408-9

Abstract:

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular

Keywords： TCGA     whole-transcriptome sequencing     HCC     liver cancer    

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Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 48-55 doi: 10.1007/s11684-012-0182-x

Abstract:

The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genomeThe increased efficiency and resolution of next-generation sequencing greatly facilitate the detectionComprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptomesequencing has significantly improved the understanding of cancer biology, diagnosis, and therapy.The present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides

Keywords： next-generation sequencing     cancer genome     whole genome sequencing     exome     transcriptome    

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Exome sequencing greatly expedites the progressive research of Mendelian diseases

Xuejun Zhang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 42-57 doi: 10.1007/s11684-014-0303-9

Abstract:

The advent of whole-exome sequencing (WES) has facilitated the discovery of rare structure and functionalCombining exome sequencing with linkage studies is one of the most efficient strategies in searchingWe illustrate the workflow of exome capture and sequencing to highlight the advantages of WES.

Keywords： genetics     whole-exome sequencing     Mendelian disease     disease gene    

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Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 23-33 doi: 10.1007/s11684-017-0607-7

Abstract:

Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunityIn recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resultedBacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirementsIn this review, we outline the significance and summarize the roles of bacterial genome sequencing inWide applications of genome sequencing and data sharing in infectious disease surveillance networks will

Keywords： genome sequencing     genomic epidemiology     bacteria     surveillance     infectious diseases    

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Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptomesequencing

Lijuan Hu,Zhirui Lin,Yanheng Wu,Juqin Dong,Bo Zhao,Yanbing Cheng,Peiyu Huang,Lihua Xu,Tianliang Xia,Dan Xiong,Hongbo Wang,Manzhi Li,Ling Guo,Elliott Kieff,Yixin Zeng,Qian Zhong,Musheng Zeng

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 61-75 doi: 10.1007/s11684-016-0436-0

Abstract: However, comprehensive information through EBV transcriptome analysis in NPC is limited.

Keywords： Epstein-Barr virus     paired-end transcriptome sequencing     latency genes     lytic genes     nasopharyngeal carcinoma    

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Plastic materials and water sources actively select and shape wastewater plastispheres over time

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 11, doi: 10.1007/s11783-022-1580-1

Abstract:

● Wastewater MPs exhibited resistomes and therefore health threats.

Keywords： Microplastics     Whole-genome metagenomic sequencing     Plastisphere     Plastic degradation     MHETase    

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine doi: 10.1007/s11684-022-0933-2

Abstract: In previous studies, the focus has been mainly on gene sequencing, and there has been a lack of researchpatients and to provide a basis for further study of the pathogenesis of the disease, we performed whole-exomeand Sanger sequencing on a large Chinese Clouston syndrome pedigree.

Keywords： Clouston syndrome     whole exome sequencing     GJB6 gene     novel variant     unique phenotype    

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Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 77-84 doi: 10.15302/J-FASE-2014010

Abstract: In this paper, we present a transcriptome analysis of , a deciduous conifer that is widely-grown inUsing high-throughput RNA sequencing, we obtained about 26 million reads from the stems of 1-, 2-, 5-Combining these with the published Roche 454 sequencing reads and the expressed sequence tags (both mainly

Keywords： Larix     transcriptome     age     wood formation     somatic embryogenesis     molecular marker    

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METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: We focused on the metabolites and key genes in the phenylpropanoid/flavonoid pathway integrated with transcriptome
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Comparative transcriptome analysis of purple-fleshed sweet potato provides insights into the molecular

Hongyuan ZHAO, Shanshan ZHANG, Feibing WANG, Ning ZHAO, Shaozhen HE, Qingchang LIU, Hong ZHAI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 214-225 doi: 10.15302/J-FASE-2018219

Abstract: Jingshu 6 and its mutant JS6-5 with high anthocyanin content by high-throughput RNA sequencing.

Keywords： anthocyanin     gene expression     mutant     purple-fleshed sweet potato     transcriptome    

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Organizational evolution of project management teams over the whole lifecycle of megaprojects: Case study

Frontiers of Engineering Management doi: 10.1007/s42524-022-0211-7

Abstract: Project management teams are critical in the implementation of megaprojects, but their evolution throughout the project lifecycle has not been clearly explained. This paper explores the organizational evolution of megaproject management teams through a longitudinal retrospective case study of the Hong Kong–Zhuhai–Macao Bridge (HZMB) project. The organizational evolution is examined in terms of management objectives, management content, and organizational structure. The organizational evolution of the HZMB project management team exhibits stage differentiation with the coexistence of turbulence and stability. Changes in the external environment are the driving force for organizational evolution, whereas a flexible organizational strategy is critical in promoting this evolution. Basing on the HZMB case study, this paper summarizes six critical measures that facilitate the organizational evolution of megaproject management teams. Our findings add value to megaproject management theory and provide a better understanding of the dynamics and complexity of megaproject organizational management.

Keywords： megaproject     organizational evolution     whole lifecycle management     project management team    

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Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 46-57 doi: 10.1007/s11705-017-1609-3

Abstract: surface proteins using genetic engineering, and is important for the development of high-performance whole-celldiscuss advanced methods for displaying multiple enzymes and a new method for the immobilization of whole-cell

Keywords： cell surface engineering     surface display     whole-cell catalysts     bioprocess    

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Efficient acetoin production from pyruvate by engineered whole-cell biocatalysis

Frontiers of Chemical Science and Engineering   Pages 425-436 doi: 10.1007/s11705-022-2229-0

Abstract: Moreover, the reusability of the cell catalysis was also tested, and the result illustrated that the whole-cellThis work therefore provided an efficient H. bluephagenesis whole-cell catalysis with a broad

Keywords： -acetolactate synthetase     α-acetolactate decarboxylase     Halomonas bluephagenesis     whole-cell    

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Monocytes Associated with Severe COVID-19 in the PBMCs of Severely Infected Patients Through Single-Cell TranscriptomeSequencing Article

Yan Zhang, Shuting Wang, He Xia, Jing Guo, Kangxin He, Chenjie Huang, Rui Luo, Yanfei Chen, Kaijin Xu, Hainv Gao, Jifang Sheng, Lanjuan Li

Engineering 2022, Volume 17, Issue 10,   Pages 161-169 doi: 10.1016/j.eng.2021.05.009

Abstract: In this study, we performed single-cell transcriptomic sequencing of peripheral blood samples collected

Keywords： COVID-19     Severe infection     Critically ill     Monocytes     Fibrosis    

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Whole-life Thinking and Engineering the Future

Roger Flanagan

Frontiers of Engineering Management 2014, Volume 1, Issue 3,   Pages 290-296 doi: 10.15302/J-FEM-2014040

Abstract: Whole-life thinking for engineers working on the built environment has become more important in a fastWhole-life thinking is not new, every project attempts to balance the initial capital cost with the operatingSystems thinking provides one approach to developing a more robust whole-life approach.New approaches are needed to produce more reliable whole-life predictions.Best value, rather than lowest cost, can be achieved by using whole-life appraisal as a part of the design

Keywords： whole-life thinking     systems thinking     complexity     chaos     risk management through life    

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Title Author Date Type Operation

TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Journal Article

Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Journal Article

Exome sequencing greatly expedites the progressive research of Mendelian diseases

Xuejun Zhang

Journal Article

Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Journal Article

Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptomesequencing

Lijuan Hu,Zhirui Lin,Yanheng Wu,Juqin Dong,Bo Zhao,Yanbing Cheng,Peiyu Huang,Lihua Xu,Tianliang Xia,Dan Xiong,Hongbo Wang,Manzhi Li,Ling Guo,Elliott Kieff,Yixin Zeng,Qian Zhong,Musheng Zeng

Journal Article

Plastic materials and water sources actively select and shape wastewater plastispheres over time

Journal Article

A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Journal Article

Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

Journal Article

METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Journal Article

Comparative transcriptome analysis of purple-fleshed sweet potato provides insights into the molecular

Hongyuan ZHAO, Shanshan ZHANG, Feibing WANG, Ning ZHAO, Shaozhen HE, Qingchang LIU, Hong ZHAI

Journal Article

Organizational evolution of project management teams over the whole lifecycle of megaprojects: Case study

Journal Article

Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Journal Article

Efficient acetoin production from pyruvate by engineered whole-cell biocatalysis

Journal Article

Monocytes Associated with Severe COVID-19 in the PBMCs of Severely Infected Patients Through Single-Cell TranscriptomeSequencing

Yan Zhang, Shuting Wang, He Xia, Jing Guo, Kangxin He, Chenjie Huang, Rui Luo, Yanfei Chen, Kaijin Xu, Hainv Gao, Jifang Sheng, Lanjuan Li

Journal Article

Whole-life Thinking and Engineering the Future

Roger Flanagan

Journal Article