Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

2009年第3卷第3期

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《医学前沿（英文）》 >> 2009年第3卷第3期 doi: 10.1007/s11684-009-0053-2

Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Department of Clinical Laboratory Sciences, Tianjin Medical University, Tianjin 300203, China;

发布日期： 2009-09-05

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摘要

Lanthanum salt is a prescription drug, but its underlying functions and mechanisms are not fully understood currently. To explore the potential therapeutic value of , cytotoxicity test was applied to investigate its effects on cell proliferation. Furthermore, we observed its influence on pro-oncogene by reverse transcription polymerase chain reaction (RT-PCR). In MCF-7 cell line, repressed cell proliferation at high concentration but had no significant inhibition effect on cell growth at low concentration. However, we observed that repressed transcription at a low concentration. This may suggest that is a potent drug to inhibit the high expression of in carcinoma cells and play a clue for inhibiting the growth and invasion of tumor.

关键词

proliferation ; c-met ; invasion ; lanthanum chloride