期刊首页 优先出版 当期阅读 过刊浏览 作者中心 关于期刊 English

《医学前沿(英文)》 >> 2019年 第13卷 第5期 doi: 10.1007/s11684-019-0704-x

PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder

. Department of Nuclear Medicine and Medical PET Center, The Second Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China;.. Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China;.. Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China;.. Department of Psychiatry, The Second Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China;.. Department of Advanced Nuclear Medicine Sciences, National Institute of Radiological Sciences,?National Institutes for Quantum and Radiological Science and Technology,?Anagawa 4-9-1, Inage-ku, Chiba, 263-8555, Japan

录用日期: 2019-07-19 发布日期: 2019-07-19

下一篇 上一篇

摘要

Panic disorder (PD) is an acute paroxysmal anxiety disorder with poorly understood pathophysiology. The dorsal periaqueductal gray (dPAG) is involved in the genesis of PD. However, the downstream neurofunctional changes of the dPAG during panic attacks have yet to be evaluated . In this study, optogenetic stimulation to the dPAG was performed to induce panic-like behaviors, and positron emission tomography (PET) imaging with F-flurodeoxyglucose ( F-FDG) was conducted to evaluate neurofunctional changes before and after the optogenetic stimulation. Compared with the baseline, post-optogenetic stimulation PET imaging demonstrated that the glucose metabolism significantly increased ( <0.001) in dPAG, the cuneiform nucleus, the cerebellar lobule, the cingulate cortex, the alveus of the hippocampus, the primary visual cortex, the septohypothalamic nucleus, and the retrosplenial granular cortex but significantly decreased ( <0.001) in the basal ganglia, the frontal cortex, the forceps minor corpus callosum, the primary somatosensory cortex, the primary motor cortex, the secondary visual cortex, and the dorsal lateral geniculate nucleus. Taken together, these data indicated that PET imaging can successfully detect downstream neurofunctional changes involved in the panic attacks after optogenetic stimulation to the dPAG.

相关研究