Cationic and amphipathic cell-penetrating peptides (CPPs): Their structures and

2015年第9卷第4期

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《化学科学与工程前沿（英文）》 >> 2015年第9卷第4期 doi: 10.1007/s11705-015-1538-y

Cationic and amphipathic cell-penetrating peptides (CPPs): Their structures and

Department of Pharmacology and Pharmaceutical Science, University of Southern California, Los Angeles, CA 90033, USA

录用日期： 2015-11-04 发布日期： 2015-11-26

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摘要

Over the past few decades, cell penetrating peptides (CPPs) have become an important class of drug carriers for small molecules, proteins, genes and nanoparticle systems. CPPs represent a very diverse set of short peptide sequences (10?30 amino acids), generally classified as cationic or amphipathic, with various mechanisms in cellular internalization. In this review, a more comprehensive assessment of the chemical structural characteristics, including net cationic charge, hydrophobicity and helicity was assembled for a large set of commonly used CPPs, and compared to results from numerous drug delivery studies. This detailed information can aid in the design and selection of effective CPPs for use as transport carriers in the delivery of different types of drug for therapeutic applications.

关键词

cell penetrating peptides ; amphipathic peptides ; drug delivery