Cystine oligomers successfully attached to peptide cysteine-rich fibrils

2016年第10卷第1期

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《化学科学与工程前沿（英文）》 >> 2016年第10卷第1期 doi: 10.1007/s11705-016-1554-6

Cystine oligomers successfully attached to peptide cysteine-rich fibrils

Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C 8000, Denmark

录用日期： 2016-01-25 发布日期： 2016-02-29

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摘要

Amyloid peptides are renowned to be related to neurodegenerative diseases, however, a fruitful avenue is to employ them as high-performance nanomaterials. These materials benefit from the intrinsic outstanding mechanical robustness of the amyloid backbone made of -strands. In this work, we exploited amyloid-like fibrils as functional material to attach pristine L-cysteine aggregates (cystine oligomers) and gold nanoparticles, without the need of templating compounds. This work will open new avenues on functional materials design and their realisation.

关键词

cysteine ; peptide fibrils ; gold nanoparticles ; amyloids ; oligomers ; nanomaterials