期刊首页 优先出版 当期阅读 过刊浏览 作者中心 关于期刊 English

2017年 第11卷 第2期

摘要

关键词

相关研究

回顶部

《化学科学与工程前沿（英文）》 >> 2017年 第11卷 第2期 doi: 10.1007/s11705-017-1624-4

Solvates and polymorphs of clindamycin phosphate: Structural, thermal stability and moisture stability studies

. School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China.. Collaborative Innovation Center of Chemical Seience and Engineering (Tianjin), Tianjin University, Tianjin 300072, China

录用日期： 2017-03-17 发布日期： 2017-05-12
HTML8 PDF 28 收藏 0

下一篇 上一篇

摘要

Clindamycin phosphate (CP), an antibacterial agent, has been reported to form several solid-state forms. The crystal structures of two CP solvates, a dimethyl sulfoxide (DMSO) solvate and a methanol/water solvate (solvate V), have been determined by single crystal X-ray diffraction. The properties and transformations of these forms were characterized by powder X-ray diffraction, Single-crystal X-ray diffraction, differential scanning calorimetry, thermo gravimetric analysis, hot-stage microscopy, and dynamic vapor sorption. Very different hydrogen bonding networks exist among the host-host and host-solvent molecules in the two crystal structures, resulting in different moisture stabilities. The thermal stabilities of the two solvates upon heating and desolvation were also studied. When the temperature was above the boiling point of methanol, solvate V converted to a polymorphic phase after a one step desolvation process, whereas the desolvation temperature of the DMSO solvate was below the boiling point of DMSO. At the relative humidity above 43%, the DMSO solvate transformed to a hydrate at 25 °C. In contrast, solvate V did not transform at any of the humidities studied.

相关研究