The brazed plate heat exchanger (BPHE) has some advantages over the plate-fin heat exchanger (PFHE) when used in natural gas liquefaction processes, such as the convenient installation and transportation, as well as the high tolerance of carbon dioxide (CO ) impurities. However, the BPHEs with only two channels cannot be applied directly in the conventional liquefaction processes which are designed for multi-stream heat exchangers. Therefore, the liquefaction processes using BPHEs are different from the conventional PFHE processes. In this paper, four different liquefaction processes using BPHEs are optimized and comprehensively compared under respective optimal conditions. The processes are compared with respect to energy consumption, economic performance, and robustness. The genetic algorithm (GA) is applied as the optimization method and the total revenue requirement (TRR) method is adopted in the economic analysis. The results show that the modified single mixed refrigerant (MSMR) process with part of the refrigerant flowing back to the compressor at low temperatures has the lowest specific energy consumption but the worst robustness of the four processes. The MSMR with fully utilization of cold capacity of the refrigerant shows a satisfying robustness and the best economic performance. The research in this paper is helpful for the application of BPHEs in natural gas liquefaction processes.