The Qinghai Lake Watershed, containing the largest saline lake in northwest of China, has suffered from severe sandy land development in recent years. This paper analyzes its daily precipitation, temperature, and wind from 1958 to 2001, and the spatial and temporal distributions of sandy land through the interpretation of remote sensing images covering four years (1977, 1987, 2000, and 2004). Results showed that since the middle of the 1960s, the daily precipitation () of 0 < ≤ 5 mm decreased, while the > 20 mm increased significantly ( < 0.05) in their annual total amounts and days. The maximum daily precipitation also increased significantly. Both the maximum dry spell and the total dry spell of more than ten days had a significant upward trend. Since the beginning of the 1960s, all the extremely high, extremely low and mean temperatures increased significantly ( < 0.01), at a rate of 0.1°C/10a, 0.2°C/10a, and 0.2°C/10a, respectively. The days with extremely high temperature had a significant upward trend, while the days with extremely low temperature had a significant downward trend. The Qinghai Lake was significantly shrinking ( < 0.01) and provided abundant sediments for Aeolian erosion. The NNW wind prevailed in the watershed, and the largest scale wind was from the west and concentrated on the dry months. As a result, the sandy land was mainly born on the east bank of Qinghai Lake. The total sandy land area in the watershed had grown from 587.4 km, 660.7 km, 697.6 km to 805.8 km, accordingly, its area percentage growing from 2.0%, 2.2%, 2.4% to 2.7%, respectively.