Air pollution remediation using photocatalytic construction materials was tested. NO and VOC uptake rates on different materials were measured in the laboratory. Effective NO and VOC abatement levels were tested under real conditions. Recommendations for implementation of photocatalytic materials are provided. In the recent years, photocatalytic self-cleaning and “depolluting” materials have been suggested as a remediation technology mainly for NO and aromatic VOCs in urban areas. A number of products incorporating the aforementioned technology have been made commercially available with the aim to improve urban air quality. These commercial products are based on the photocatalytic properties of a thin layer of TiO at the surface of the material (such as glass, pavement, etc.) or embedded in paints or concrete. The use of TiO photocatalysts as an emerging air pollution control technology has been reported in many locations worldwide. However, up to now, the effectiveness measured in situ and the expected positive impact on air quality of this relatively new technology has only been demonstrated in a limited manner. Assessing and demonstrating the effectiveness of these depolluting techniques in real scale applications aims to create a real added value, in terms of policy making (i.e., implementing air quality strategies) and economics (by providing a demonstration of the actual performance of a new technique).