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《工程(英文)》 >> 2016年 第2卷 第1期 doi: 10.1016/J.ENG.2016.01.028

生物材料在心脏修复和再生中的应用

a. Institute of Medical Science & Department of Surgery, Division of Cardiovascular Surgery, University of Toronto, Toronto, ON M5G 2M9, Canada
b. Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150001, China
c. Division of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada

收稿日期: 2015-11-24 修回日期: 2017-03-07 录用日期: 2017-03-09 发布日期: 2016-03-31

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摘要

心血管疾病是全世界主要致死原因之一。人们对新的干预性治疗手段的需求与日俱增。虽然药物和手术治疗极大地改善了心血管疾病患者的生活质量,但人们还是需要价格更便宜、副作用更小的治疗手段。天然和合成生物材料无论是作为给药载体,还是替代支架的细胞外基质,在心脏修复和再生中都展现出巨大的潜力。本文探讨了目前治疗心血管疾病的几种方式和应用于上述疾病干预性治疗的生物材料;着重研究了导电聚合物在纠正局部缺血性心脏病引发的传导异常及其在心脏起搏器中应用的可能性,以改善心肌梗死状态下的传导路径。

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