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《工程(英文)》 >> 2017年 第3卷 第1期 doi: 10.1016/J.ENG.2017.01.003

膝关节骨性关节炎治疗的再生工程:生物材料以及基于细胞的技术

a Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA
b Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
c Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
d Department of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, CT 06269, USA
e Department of Materials Science and Engineering, School of Engineering, University of Connecticut, Storrs, CT 06269, USA
f Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA
g Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
h Department of Chemical and Biomolecular Engineering, School of Engineering, University of Connecticut, Storrs, CT 06269, USA

# These authors contributed equally to this work

收稿日期: 2016-10-31 修回日期: 2016-12-28 录用日期: 2016-12-30 发布日期: 2017-02-14

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摘要

膝关节骨性关节炎(OA) 是世界上常见的关节炎,其发病率年上升。不断上涨的治疗费用给患者带来了经济负担。膝关节OA 治疗的两个早期干预目标是减轻膝关节的疼痛和关节软骨的损害。目前用于治疗膝关节OA 的方法虽取得了一定疗效,但仍没有种方法可达到全膝关节置换术(TKA) 的治疗效果TKA 主要应用于治疗末期膝关节OA,其缺点是有手术侵入性和手术费用昂贵。因而,应该重视创新性的再生术,以推迟甚至消除患者对TKA 的需求一些基于生物材料和细胞的疗法目前正处于发展阶段,并已在临床前和临床研究方面取得了初步进展单独或联合应用先进的生物材料和干细胞治疗膝关节OA 可减轻疼痛,使损害的关节软骨再生。在此综述中,我们讨论了膝关节OA 疼痛和软骨损害的发病机制,并探讨了该病的新治疗策略及其局限

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