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《工程(英文)》 >> 2017年 第3卷 第5期 doi: 10.1016/J.ENG.2017.03.011

植物化学物质的生物功能及其在家畜中的应用研究——以Nrf2/Keap1系统为目标

a Key Laboratory for Food Science and Biotechnology of Hunan Province, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China
b Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China
c The United Graduate School of Agricultural Sciences, Faculty of Agriculture, Kagoshima University, Korimoto, Kagoshima 890-0065, Japan

录用日期: 2017-07-05 发布日期: 2017-10-31

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摘要

活性氧(ROS)对人类和其他动物健康的负面影响非常值得关注。ROS可能由机械伤害、热刺激、感染和化学刺激产生。核转录相关因子(Nrf2)及其伴侣蛋白Keap1组成的Nrf2/Keap1系统在抗氧化作用中扮演着重要角色。Nrf2/Keap1系统通过与抗氧化反应元件(ARE)相互作用,调控一系列解毒酶和抗氧化酶基因的表达来维持机体氧化还原的平衡状态。膳食植物化学物质在蔬菜、水果、谷物和草药中普遍存在,研究发现其有益健康,还可通过多种途径调节Nrf2介导的II相酶来提高家畜的生长性能和肉质。然而,关于植物化学物质作用效果的大量数据有些混乱,需要根据植物化学物质的功能和作用机制进行相应的分类。在本文中,我们首先介绍了植物化学物质的抗氧化性及其与Nrf2/Keap1系统的关系,并总结了植物化学物质通过靶向Nrf2/Keap1系统,对家畜生长性能、肉质和肠道菌群的影响。这些详尽的数据有助于阐述植物化学物质在家畜中潜在的生物功能特性。

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