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《工程(英文)》 >> 2019年 第5卷 第1期 doi: 10.1016/j.eng.2018.11.008

中医方证代谢组学——中药效应评价的有效途径

National Chinmedomics Research Center & Sino-America Chinmedomics Technology Collaboration Center & National TCM Key Laboratory of Serum Pharmacochemistry & Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150040, China

收稿日期: 2018-05-23 修回日期: 2018-09-20 录用日期: 2018-11-06 发布日期: 2018-11-30

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摘要

有效性评价是发现中药药效物质基础、先导化合物和质量标志物的重要前提,因此急需建立一种生物学语言,将中药有效性科学地表达出来,进一步凸显中医药的实用价值。证候和方剂是中医药的重要组成部分,与中药有效性直接相关。我们以证候和方剂为研究对象,建立了科学评价中药有效性的创新方法学体系——中医方证代谢组学。它将中药血清药物化学理论与代谢组学技术有机整合,在解决证候生物标记物的基础上,建立方剂药效生物评价体系,发现并确认中药药效物质基础。该策略为提高中医理论和临床实践的科学价值提供了有力支持。本文概述了中医方证代谢组学的研究策略,利用该方法揭示临床常见中医证候生物标记物及开展相关方剂的有效性评价研究,着重阐述了中药药效物质基础及质量标记物的发现。

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