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《工程(英文)》 >> 2021年 第7卷 第3期 doi: 10.1016/j.eng.2020.06.026

植物乳杆菌CCFM8610缓解肠易激综合征并改善肠道菌群失调——一项随机、双盲、安慰剂对照的先导性临床试验

a State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
b School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Hwa Chong Institution (College), Singapore 269734, Singapore
d International Joint Research Laboratory for Probiotics, Jiangnan University, Wuxi 214122 China
e National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China
f Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi 214122, China
g (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China
h The Tinghu People's Hospital, Yancheng 224002, China
i Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China

收稿日期: 2020-04-09 修回日期: 2020-05-17 录用日期: 2020-06-18 发布日期: 2020-12-24

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摘要

腹泻型肠易激综合征(irritable bowel syndrome with diarrhea, IBS-D)是一种伴有腹泻等复杂临床症状的慢性肠功能障碍,对患者的日常生活和精神状态具有极大影响。一些研究报道称,摄入益生菌可显著缓解多种肠道疾病。本研究的目的是探究一株具有多种保健作用的益生植物乳杆菌(Lactobacillus plantarum)CCFM8610对IBS-D的缓解作用。这项研究是一项为期12周的随机、双盲、安慰剂对照的先导性临床试验。75名患者被随机分配接受安慰剂、低聚糖或植物乳杆菌CCFM8610 [每天1 × 1010 CFU(菌落形成单位)],进行为期两周的观察、8周的干预及两周的后续随访。采用IBS症状严重程度量表(IBS-SSS)及IBS生活质量量表(IBS-QOL)评定患者的临床症状和生活质量。在干预期结束时,测定肠道菌群组成和多样性的变化。结果表明,口服植物乳杆菌CCFM8610显著降低了IBS-SSS和IBS-QOL评分,减轻了IBS-D症状的严重程度,恢复了肠道菌群的多样性,降低了与腹胀相关的甲烷短杆菌属(Methanobrevibacter)的相对丰度,增加了厌氧棒状菌属(Anaerostipes)、双歧杆菌属(Bifidobacterium)、丁酸弧菌属(Butyricimonas)及臭杆菌属(Odoribacter)等丁酸生产种属的相对丰度。这些结果表明,摄入植物乳杆菌CCFM8610可以显著缓解IBS-D患者的临床症状及肠道菌群失调。植物乳杆菌CCFM8610对IBS-D的缓解作用可能与肠道中丁酸生产种属的相对丰度上升有关。

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