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《工程(英文)》 >> 2021年 第7卷 第2期 doi: 10.1016/j.eng.2020.12.006

基于就医人群的中国多囊卵巢综合征女性的临床表型和治疗结局—— 身体质量指数与地理分布的影响

a First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China
b Xuzhou Central Hospital, Xuzhou 221009, China

# These authors contributed equally to this work.

收稿日期: 2019-04-13 修回日期: 2020-02-15 录用日期: 2020-08-20 发布日期: 2021-02-10

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摘要

遗传因素、生活方式和环境因素与多囊卵巢综合征(PCOS)的发生相关。身体质量指数(BMI)的增加会加剧生殖及代谢障碍,降低PCOS女性的生育能力。本文对在中国大陆21个研究中心开展的一项大样本、多中心、随机对照试验进行二次分析。共有1000名PCOS女性参加本试验。其中,998名PCOS女性被纳入分析。BMI增加与月经失调加剧、高睾酮水平、高代谢综合征患病率以及生活质量降低相关。BMI正常组、超重组和肥胖组的女性人均排卵率分别为83.0%、78.2%和63.6%(P < 0.001),活产率分别为23.6%、18.1%和15.3%(P = 0.030)。与中国南方的PCOS患者相比,北方的PCOS患者生殖结局较差,血糖和血脂代谢不良,运动量少,以及总排卵率更低(81.2% vs 74.8%,绝对差:6.4%,95%置信区间:1.2%~11.5%)。结果显示,中国南北方的汉族PCOS女性具有典型的表型特征。与生活在中国南方的女性相比,在同样的干预措施下,中国北方的女性BMI更高,糖脂代谢障碍更严重,临床结局更差。表型特征及排卵的差异可以通过BMI差异加以解释。

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