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《工程(英文)》 >> 2022年 第13卷 第6期 doi: 10.1016/j.eng.2021.10.021

用于细胞疗法的大尺寸装载器械

a College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
b Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
c Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, United States
d Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, San Antonio, TX, 78249, United States
e Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, United States
f Zhejiang Laboratory of Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, China
g MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

# These authors contributed equally to this work.

收稿日期: 2021-07-07 修回日期: 2021-09-24 录用日期: 2021-10-25 发布日期: 2022-02-17

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摘要

大尺寸装载器械可为移植的自体或异体细胞提供免疫豁免环境而被广泛应用于细胞疗法。大尺寸装载器械可为细胞提供力学及理化条件支持,维持细胞的增殖,提升细胞的治疗功能。包括膜控释放系统、水凝胶、微针阵列贴片和3D支架等在内的大尺寸装载器械在维持细胞长期生存和加强其治疗功能方面已经展现出优异的实验室和临床前治疗效果。最近,本领域的研究重点是将这些器械的应用扩展到新的细胞疗法,如用于嵌合抗原受体(CAR)-T细胞递送和心血管疾病治疗,以及探索新的材料、构建方法和工作原理用以提高细胞治疗效果和延长治疗时间。本文中,我们综述了与改善大尺寸装载器械性能及推进其临床应用相关的创新性平台、方法及转化成果。此外,本文对该领域存在的机遇和挑战进行了总结和展望。

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