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《工程(英文)》 >> 2023年 第20卷 第1期 doi: 10.1016/j.eng.2021.11.018

宿主微生物组内的基因组突变——适应性进化或净化选择

a School of Food Science and Engineering, Hainan University, Haikou 570228, China
b Department of Pediatrics, University of California San Diego, La Jolla, CA, 92093, USA
c Center for Microbiome Innovation, Jacobs School of Engineering, University of California San Diego, La Jolla, CA 92093, USA
d Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA
e Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, 92093, USA

收稿日期 :2021-08-16 修回日期 :2021-10-23 录用日期 : 2021-11-15 发布日期 :2022-01-21

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摘要

二代测序技术转变了人们评估宿主相关微生物区系和微生物组的分类组成功能的能力。未来10 年将会开展更多的人类微生物组研究,特别是那些探索微生物组内基因组突变的研究。本文聚焦于微生物组内菌株之间的共同进化,塑造了宿主肠道微生物种内和种间的菌株水平多样性。还探讨了微生物基因组突变与常见代谢疾病之间的关联,以及病原体和益生菌在入侵和定植过程中的适应性进化。最后,讨论了注释和分析微生物基因组突变方法和算法的研究进展。

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