Effects of DNA damage on oocyte meiotic maturation and early embryonic development

2014年第1卷第3期

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《农业科学与工程前沿（英文）》 >> 2014年第1卷第3期 doi: 10.15302/J-FASE-2014035

Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China

录用日期： 2015-01-16 发布日期： 2015-01-27

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摘要

DNA damage is one of the most common threats to meiotic cells. It has the potential to induce infertility and genetic abnormalities that may be passed to the embryo. Here, we reviewed exogenous factors which could induce DNA damage. Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic development. Complex DNA damage, double-strand breaks, represents a more difficult repair process and involves various repair pathways. Understanding the mechanisms involved in DNA damage responses may improve therapeutic strategies for ovarian cancer and fertility preservation.

关键词

DNA damage ; double-strand breaks (DSBs) ; oocyte ; embryo