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2015年 第2卷 第3期

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《农业科学与工程前沿（英文）》 >> 2015年 第2卷 第3期 doi: 10.15302/J-FASE-2015056

A comprehensive analysis of immunoglobulin heavy chain genes in the Bactrian camel (

1. Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China.2. State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China.3. Laboratory of Animal Molecular Genetics, College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China.4. Key Laboratory of Animal Genetics, Breeding and Reproduction, Inner Mongolia Agricultural University, Hohhot 010018, China.5. Bioyong Technology Inc., Beijing 100080, China

录用日期： 2015-06-18 发布日期： 2015-11-10
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Heavy chain only antibodies (HCAbs) represent a rare type of antibody that is devoid of light chains and the CH1 domain that have been reported in cartilaginous fish and camelids. By analyzing transcript data and genome sequences, we conducted a comprehensive analysis of Bactrian camel immunoglobulin heavy chain genes. Based on the transcript data, one gene, five genes, one gene and one gene were found. Additionally, the variable region of HCAbs (VHH) and the conventional antibodies (VH) sequences associated with the , and genes were amplified. Based on these genome sequences, seven , six , , , , , and genes and a portion of a gene were observed. Different Kozak sequences within different VH families were found in our analysis, and the variability index differed between the VHH3 and VH3 families. Phylogenetic analysis of the constant regions of the camelid immunoglobulin genes indicates that these genes appeared before the evolutionary divergence of Bactrian camels and dromedaries.

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