2020年 第7卷 第2期
《农业科学与工程前沿（英文）》 >> 2020年 第7卷 第2期 doi: 10.15302/J-FASE-2019309
A brief review of genome editing technology for generating animal models
. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.. University of the Chinese Academy of Sciences, Beijing 100049, China.. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.. Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100193, China.. State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.. Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
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摘要
The recent development of genome editing technologies has given researchers unprecedented power to alter DNA sequences at chosen genomic loci, thereby generating various genetically edited animal models. This mini-review briefly summarizes the development of major genome editing tools, focusing on the application of these tools to generate animal models in multiple species.
关键词
animal model ; CRISPR ; genome editing ; TALEN ; ZFN
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