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《中国工程科学》 >> 2009年 第11卷 第5期

诱导性多潜能干细胞(iPS)研究:现状与展望

1. 解放军总医院基础医学研究所,北京 100853;

2. 解放军总医院第一附属医院全军创伤修复重点实验室,北京 100037

资助项目 :国家重点基础研究规划项目(2005CB522603);国家自然科学基金资助项目(30672176,30730090) 收稿日期: 2008-12-16

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摘要

通过特定的基因组合与转染可以将已分化的体细胞诱导重编程为多潜能干细胞(iPS),是近年来干细胞研究领域最令人瞩目的一项新的干细胞制造技术。与胚胎干细胞(ES)不同,iPS细胞的制造不需要毁损胚胎,因而不会涉及更多的伦理学问题。iPS的出现不仅为体细胞重编程去分化机制的研究注入了新的活力,而且为疾病发生发展相关机制研究与特异的细胞治疗,特别是再生医学带来新的曙光。目前,iPS的研究尚处于初级阶段,文章就iPS的研究现状与应用前景进行综述和展望。

关键词

体细胞 ; 重编程 ; iPS细胞

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参考文献

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