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《中国工程科学》 >> 2014年 第16卷 第5期

锑元素与先天性心脏病关系的病例对照研究

福建医科大学教学医院,福建省妇幼保健院,福州 350000

资助项目 :福建临床重点专科建设资助项目[闽卫科教(2012)92号];福建省科技计划项目(2012Y0011);国家重点基础研究发展计划项目腔北调(2010CB529501) 收稿日期: 2014-04-08 发布日期: 2014-05-26 15:13:53.000

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摘要

采用以院为基础的病例对照研究,在福建省妇幼保健院(三级甲等医院)募集新近发生的69 例胎儿先天性心脏病病例,以1∶1 配对的方法设立对照组,采用电感耦合等离子体质谱仪分析方法,测定病例组和对照组孕妇孕期头发中锑、锌、铜、铁、铅等元素的含量,并问卷调查孕早期危险因素的暴露情况,用SPSS19.0 Cox 比例风险模型进行流行病学多因素分析。孕妇发锑含量偏高(相对危险度的比值比(OR) =33.833;95 %可信区间(CI):4.060~281.929)、孕期使用不锈钢餐具(OR=8.981,95 % CI:1.085~74.327)、居所周围50 m有马路(OR=11.067,95 % CI:1.025~119.521)是先天性心脏病的危险因素。孕期锑负荷增加可能是先天性心脏病的原因之一。

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