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《中国工程科学》 >> 2014年 第16卷 第5期

HCG注射日血清雌孕激素对试管婴儿妊娠结局的影响

武汉大学人民医院生殖医学中心,武汉 430060

收稿日期: 2014-03-31 发布日期: 2014-05-26 15:12:54.000

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摘要

探究体外受精—胚胎移植/单精子卵泡浆内注射-胚胎移植(IVF/ICSI)患者注射人绒毛膜促性腺激素(HCG)日血清雌孕激素水平对妊娠结局的影响。回顾分析武汉大学人民医院生殖医学中心2011 年9 月—2012 年9 月符合相关条件行IVF的新鲜周期患者1 270 例,按血清孕酮值将其分为两组进行比较,低孕酮组HCG日血清孕酮值<2.0 pg/mL,高孕酮组HCG日血清孕酮值≥2.0 pg/mL;再按照孕酮与雌二醇比值(P/E2)分为两组,以0.6 作为P/E2切点。比较两组间的女方年龄、不孕年限、基础卵泡刺激素(FSH)值、促性腺激素(Gn)天数、Gn用量、获卵数、MII 卵数、受精数、卵裂数、优胚数、移植数、E2值、临床妊娠率、胚胎着床率。高孕酮组Gn天数、Gn用量、获卵数、MII数、卵裂数、E2值增加,但临床妊娠率、胚胎着床率减少;高P/E2比值组女方年龄、基础FSH、Gn 天数、Gn 用量、获卵数、受精数、优胚数、P 值均增加,妊娠结局无明显差异。HCG注射日血清孕酮水平过高会降低临床妊娠率及胚胎着床率。

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参考文献

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