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Occupational risk of exposure to methicillin-resistant (MRSA) and the quality of infection hygiene in nursing homes

《环境科学与工程前沿（英文）》 2021年第15卷第3期 doi: 10.1007/s11783-020-1333-y

摘要：

• Staff members were not colonised with MRSA.

关键词： Antibiotic resistance Airborne MRSA Bioaerosols Healthcare-associated infections Healthcare worker Occupational health

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Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

null

《医学前沿（英文）》 2013年第7卷第3期页码 275-276 doi: 10.1007/s11684-013-0285-z

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Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell

《医学前沿（英文）》页码 957-968 doi: 10.1007/s11684-021-0910-1

摘要： Skin and soft tissue infections (SSTIs) refer to infections involving the skin, subcutaneous tissue, fascia, and muscle. In transplant populations with hematological malignancies, an immunocompromised status and the routine use of immunosuppressants increase the risk of SSTIs greatly. However, to date, the profiles and clinical outcomes of SSTIs in hematopoietic stem cell transplantation (HSCT) patients remain unclear. This study included 228 patients (3.67%) who developed SSTIs within 180 days after allogeneic HSCT from January 2004 to December 2019 in Peking University People’s Hospital. The overall annual survival rate was 71.5%. We compared the differences between survivors and non-survivors a year after transplant and found that primary platelet graft failure (PPGF), comorbidities of acute kidney injury (AKI), and hospital-acquired pneumonia (HAP) were independent risk factors for death in the study population. A PPGF–AKI–HAP risk stratification system was established with a mortality risk score of 1×PPGF+1×AKI+1×HAP. The areas under the curves of internal and external validation were 0.833 (95% CI 0.760–0.906) and 0.826 (95% CI 0.715–0.937), respectively. The calibration plot revealed the high consistency of the estimated risks, and decision curve analysis showed considerable net benefits for patients.

关键词： skin and soft tissue infections hematopoietic stem cell transplantation risk stratification system mortality

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Blockchain application in healthcare service mode based on Health Data Bank

Jianxia GONG, Lindu ZHAO

《工程管理前沿（英文）》 2020年第7卷第4期页码 605-614 doi: 10.1007/s42524-020-0138-9

摘要： Blockchain is commonly considered a potential disruptive technology. Moreover, the healthcare industry has experienced rapid growth in the adoption of health information technology, such as electronic health records and electronic medical records. To guarantee data privacy and data security as well as to harness the value of health data, the concept of Health Data Bank (HDB) is proposed. In this study, HDB is defined as an integrated health data service institution, which bears no “ownership” of health data and operates health data under the principal–agent model. This study first comprehensively reviews the main characters of blockchain and identifies the blockchain-based healthcare industry projects and startups in the areas of health insurance, pharmacy, and medical treatment. Then, we analyze the fundamental principles of HDB and point out four challenges faced by HDB’s sustainable development: (1) privacy protection and interoperability of health data; (2) data rights; (3) health data supervision; (4) and willingness to share health data. We also analyze the important benefits of blockchain adoption in HDB. Furthermore, three application scenarios including distributed storage of health data, smart-contract-based healthcare service mode, and consensus-algorithm-based incentive policy are proposed to shed light on HDB-based healthcare service mode. In the end, this study offers insights into potential research directions and challenges.

关键词： Health Data Bank blockchain data assets smart contract incentive mechanism

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中国健康服务业发展战略研究

韩德民,卢九星,李星明,李建

《中国工程科学》 2017年第19卷第2期页码 21-28 doi: 10.15302/J-SSCAE-2017.02.004

摘要：

为落实健康中国发展战略，推进中国健康服务业的发展，中国工程院于2015 年启动“中国健康服务业发展战略研究”重大咨询项目。课题自启动以来，组织了28位院士和150余位专家，对京上广深等一至三线共12个城市进行了广泛的社会调查。本文在大量社会调查的基础上，从健康服务业的概念、内涵、发展特点入手，深入分析了国内健康服务业的发展现状；以全方位、全覆盖、全过程建立健康服务保障体系为目标，对健康服务业的定位、发展思路，城乡理想模式等进行了深入探讨；并针对健康管理体系建设、养生养老、医养结合、健康保险、社会办医、金融保障等重点问题，提出了为顺应中国健康服务业发展战略顺畅实施的保障措施和相关建议。

关键词：健康服务业全民健康发展战略

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Personalized biomedical devices & systems for healthcare applications

I-Ming CHEN, Soo Jay PHEE, Zhiqiang LUO, Chee Kian LIM

《机械工程前沿（英文）》 2011年第6卷第1期页码 3-12 doi: 10.1007/s11465-011-0209-z

摘要：

With the advancement in micro- and nanotechnology, electromechanical components and systems are getting smaller and smaller and gradually can be applied to the human as portable, mobile and even wearable devices. Healthcare industry have started to benefit from this technology trend by providing more and more miniature biomedical devices for personalized medical treatments in order to obtain better and more accurate outcome. This article introduces some recent development in non-intrusive and intrusive biomedical devices resulted from the advancement of niche miniature sensors and actuators, namely, wearable biomedical sensors, wearable haptic devices, and ingestible medical capsules. The development of these devices requires carful integration of knowledge and people from many different disciplines like medicine, electronics, mechanics, and design. Furthermore, designing affordable devices and systems to benefit all mankind is a great challenge ahead. The multi-disciplinary nature of the R&D effort in this area provides a new perspective for the future mechanical engineers.

关键词： personalized medical devices wearable sensor haptic device ingestible medical capsule

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Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

《医学前沿（英文）》 2008年第2卷第4期页码 323-331 doi: 10.1007/s11684-008-0062-6

摘要： Hypertension is characterized by vascular smooth muscle constriction and vascular remodeling involving cell migration, hypertrophy and growth. Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has been shown to be a critical cellular component that regulates various smooth muscle functions. In this review, the molecular structure and protein interactions of the CAS family members are summarized. Evidence for the role of CAS in the regulation of vascular smooth muscle contractility is presented. Contraction stimulation induces CAS phosphorylation on Tyr-410 in arterial smooth muscle, creating the binding site for the Src homology (SH) 2/SH3 protein CrkII, which activates neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin assembly and force development. The functions of CAS in cell migration, hypertrophy and growth are also summarized. Abelson tyrosine kinase (Abl), c-Src, focal adhesion kinase (FAK), proline-rich tyrosine kinase 2 (PYK2), protein tyrosine phosphatase-proline, glutamate, serine and threonine sequence protein (PTP-PEST) and SHP-2 have been documented to coordinate the phosphorylation and dephosphorylation of CAS. The downstream signaling partners of CAS in the context of cell motility, hypertrophy, survival and growth are also discussed. These new findings establish the important role of CAS in the modulation of vascular smooth muscle functions. Furthermore, the upstream regulators of CAS may be new biologic targets for the development of more effective and specific treatment of cardiovascular diseases such as hypertension.

关键词： Contraction stimulation phosphatase-proline molecular structure discovered hypertension

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区域性医疗集团资源协同仿真建模和政策建议研究

胡依群,苏强,李晓雪,郑静晨

《中国工程科学》 2017年第19卷第2期页码 43-49 doi: 10.15302/J-SSCAE-2017.02.007

摘要：

为了缓解居民“看病难、看病贵”的问题，我们构建了“社区–医院”的二级医疗服务系统概念模型，并建立了患者偏好的函数模型和转诊机制，采用AnyLogic软件对系统进行建模，并以上海市嘉定区为例，通过引入实际案例数据展示了该模型如何用于探讨不同医疗合作模式和医疗改革政策，结果显示，提升基层医疗服务质量以及医保报销比例能够有效提升医疗服务系统的整体效率。

关键词：智能体仿真政策仿真医疗改革患者选择行为

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Serologic study on the outbreak of acute upper respiratory tract infections caused by adenovirus 3

JIANG Lufang, JU Liwen, LIN Yuzun, ZHOU Liandi, YU Shunzhang, JIANG Qingwu, JIANG Renjie

《医学前沿（英文）》 2007年第1卷第2期页码 215-218 doi: 10.1007/s11684-007-0041-3

摘要： From April to June, 2004, an outbreak of acute upper respiratory tract infections (AURTI) occurred in the north area of Jiangsu Province, China. Twenty throat swabs were collected with 13 of them presenting an adenovirus (Ad)-like cytopathogenic effect on HEp-2. These were verified as Ad by the electron microscope, direct immunofluorescence assay and Ad primer-mediated PCR. Moreover, they were identified as adenovirus type 3 (Ad3) by type-specific PCR and sequencing of the amplification products. Subsequent serologic studies were carried out to finally diagnose and document the outbreak. The neutralization test of paired serum of six in nine cases show obviously increased antibodies titers. The positive rate of IgM, IgG and recovery phase neutralization antibodies of the cases were 3.7%, 44.4% and 59.5% respectively while those of the controls were 0%, 8.3% and 33.3% respectively. The values of Chi-Square were 0.510, 0.018 and 0.226 respectively. The concordance between IgG detected by ELISA and neutralization anti bodies detected by the neutralization test was 61.4% and the value of Kappa was 0.070. By the serologic study, we can definitively diagnose that this outbreak of acute respiratory infections was caused by Adenovirus 3.

关键词： Twenty Adenovirus cytopathogenic type-specific AURTI

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Epidemiology of fungal infections in China

null

《医学前沿（英文）》 2018年第12卷第1期页码 58-75 doi: 10.1007/s11684-017-0601-0

摘要：

With the increasing number of immunocompromised hosts, the epidemiological characteristics of fungal infections have undergone enormous changes worldwide, including in China. In this paper, we reviewed the existing data on mycosis across China to summarize available epidemiological profiles. We found that the general incidence of superficial fungal infections in China has been stable, but the incidence of tinea capitis has decreased and the transmission route has changed. By contrast, the overall incidence of invasive fungal infections has continued to rise. The occurrence of candidemia caused by species other than and including some uncommon species has increased recently in China. Infections caused by have also propagated in recent years, particularly with the emergence of azole-resistant . An increasing trend of cryptococcosis has been noted in China, with var. ST 5 genotype isolates as the predominant pathogen. Retrospective studies have suggested that the epidemiological characteristics of pneumonia in China may be similar to those in other developing countries. Endemic fungal infections, such as sporotrichosis in Northeastern China, must arouse research, diagnostic, and treatment vigilance. Currently, the epidemiological data on mycosis in China are variable and fragmentary. Thus, a nationwide epidemiological research on fungal infections in China is an important need for improving the country’s health.

关键词： fungi infection epidemiology China

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Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

《医学前沿（英文）》 2022年第16卷第3期页码 459-466 doi: 10.1007/s11684-021-0841-x

摘要： Whether Fanconi anemia (FA) heterozygotes are predisposed to bone marrow failure and hematologic neoplasm is a crucial but unsettled issue in cancer prevention and family consulting. We retrospectively analyzed rare possibly significant variations (PSVs) in the five most obligated FA genes, BRCA2, FANCA, FANCC, FANCD2, and FANCG, in 788 patients with aplastic anemia (AA) and hematologic malignancy. Sixty-eight variants were identified in 66 patients (8.38%). FANCA was the most frequently mutated gene (n = 29), followed by BRCA2 (n = 20). Compared with that of the ExAC East Asian dataset, the overall frequency of rare PSVs was higher in our cohort (P = 0.016). BRCA2 PSVs showed higher frequency in acute lymphocytic leukemia (P = 0.038), and FANCA PSVs were significantly enriched in AA and AML subgroups (P = 0.020; P = 0.008). FA-PSV-positive MDS/AML patients had a higher tumor mutation burden, higher rate of cytogenetic abnormalities, less epigenetic regulation, and fewer spliceosome gene mutations than those of FA-PSV-negative MDS/AML patients (P = 0.024, P = 0.029, P = 0.024, and P = 0.013). The overall PSV enrichment in our cohort suggests that heterozygous mutations of FA genes contribute to hematopoietic failure and leukemogenesis.

关键词： Fanconi anemia aplastic anemia hematologic malignancy germline predisposition

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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

《医学前沿（英文）》页码 714-722 doi: 10.1007/s11684-021-0888-8

摘要： A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposed. We aim to examine the associations of MAFLD, particularly its discordance from non-alcoholic fatty liver disease (NAFLD), with the progression of elevated brachial-ankle pulse wave velocity (baPWV) and albuminuria in a community-based study sample in Shanghai, China. After 4.3 years of follow-up, 778 participants developed elevated baPWV and 499 developed albuminuria. In comparison with the non-MAFLD group, the multivariable adjusted odds ratio (OR) of MAFLD group for new-onset elevated baPWV was 1.25 (95% confidence interval (CI) 1.01–1.55) and 1.35 (95% CI 1.07–1.70) for albuminuria. Participants without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria (OR 1.77; 95% CI 1.07–2.94). Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or albuminuria. In conclusion, MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index, waist circumference, and hip circumference. Individuals without NAFLD but diagnosed as MAFLD had high risk of albuminuria, supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients.

关键词： metabolic dysfunction-associated fatty liver disease non-alcoholic fatty liver disease fibrosis score brachial-ankle pulse wave velocity albuminuria

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Protecting healthcare personnel from 2019-nCoV infection risks: lessons and suggestions

Zhiruo Zhang, Shelan Liu, Mi Xiang, Shijian Li, Dahai Zhao, Chaolin Huang, Saijuan Chen

《医学前沿（英文）》 2020年第14卷第2期页码 229-231 doi: 10.1007/s11684-020-0765-x

摘要： The outbreak of a novel coronavirus disease (COVID-19, caused by the 2019-nCoV infection) in December 2019 is one of the most severe public health emergencies since the founding of People’s Republic of China in 1949. Healthcare personnel (HCP) nationwide are facing heavy workloads and high risk of infection, especially those who care for patients at the epicenter of the outbreak, Hubei Province. Sadly, as of February 20, 2020, over two thousand COVID-19 cases are confirmed among HCP from 476 hospitals nationwide, with nearly 90% of them from Hubei Province. Based on literature search and interviews with some HCP working at Wuhan, capital city of Hubei, we have summarized some of the effective measures taken to reduce infection among HCP, and also made suggestions for improving occupational safety during an infectious disease outbreak. The experience and lessons learned should be a valuable asset for international health community to contain the ongoing COVID-19 epidemic around the world.

关键词： healthcare personnel COVID-19 infectious diseases

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Transparent exopolymer particles (TEPs)-associated protobiofilm: A neglected contributor to biofouling

《环境科学与工程前沿（英文）》 2021年第15卷第4期 doi: 10.1007/s11783-020-1361-7

摘要：

• Bacteria could easily and quickly attached onto TEP to form protobiofilms.

关键词： Transparent exopolymer particles (TEPs) TEP-protobiofilm Bacteria attachment Biofouling of membrane

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infections among diarrheal outpatients in Shanghai: a retrospective case study

null

《医学前沿（英文）》 2018年第12卷第1期页码 98-103 doi: 10.1007/s11684-018-0614-3

摘要：

Cyclospora cayetanensis is a foodborne and waterborne pathogen that causes endemic and epidemic human diarrhea worldwide. A few epidemiological studies regarding C. cayetanensis infections in China have been conducted. During 2013, a total of 291 stool specimens were collected from patients with diarrhea at a hospital in urban Shanghai. C. cayetanensis was not detected in any of the stool specimens by traditional microscopy, whereas five stool specimens (1.72%, 5/291) were positive by PCR. These positive cases confirmed by molecular technology were all in the adult group (mean age 27.8 years; 2.94%, 5/170) with watery diarrhea. Marked infection occurred in the rainy season of May and July. Sequence and phylogenetic analyses of the partial 18S rRNA genes of C. cayetanensis isolated showed intra-species diversity of this parasite. This study showed, for the first time, that C. cayetanensis is a pathogen in outpatients with diarrhea in Shanghai, albeit at a low level. However, the transmission dynamics of this parasite in these patients remain uncertain.

关键词： Cyclospora cayetanensis outpatients with diarrhea stool specimens 18S rRNA gene

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标题作者时间类型操作

Occupational risk of exposure to methicillin-resistant (MRSA) and the quality of infection hygiene in nursing homes

期刊论文

Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus

null

期刊论文

Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell

期刊论文

Blockchain application in healthcare service mode based on Health Data Bank

Jianxia GONG, Lindu ZHAO

期刊论文

中国健康服务业发展战略研究

韩德民,卢九星,李星明,李建

期刊论文

Personalized biomedical devices & systems for healthcare applications

I-Ming CHEN, Soo Jay PHEE, Zhiqiang LUO, Chee Kian LIM

期刊论文

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

期刊论文

区域性医疗集团资源协同仿真建模和政策建议研究

胡依群,苏强,李晓雪,郑静晨

期刊论文

Serologic study on the outbreak of acute upper respiratory tract infections caused by adenovirus 3

JIANG Lufang, JU Liwen, LIN Yuzun, ZHOU Liandi, YU Shunzhang, JIANG Qingwu, JIANG Renjie

期刊论文

Epidemiology of fungal infections in China

null

期刊论文

Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies

期刊论文

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

期刊论文

Protecting healthcare personnel from 2019-nCoV infection risks: lessons and suggestions

Zhiruo Zhang, Shelan Liu, Mi Xiang, Shijian Li, Dahai Zhao, Chaolin Huang, Saijuan Chen

期刊论文

Transparent exopolymer particles (TEPs)-associated protobiofilm: A neglected contributor to biofouling

期刊论文

infections among diarrheal outpatients in Shanghai: a retrospective case study

null

期刊论文

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