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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

《医学前沿（英文）》 2021年 第15卷 第6期   页码 942-942 doi: 10.1007/s11684-021-0876-z

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Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study

《环境科学与工程前沿（英文）》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1716-y

摘要：

● A systematic framework was developed to identify i-PPCPs for landfill leachate.

关键词： Landfill leachates     PPCPs     Indicator     Screening criteria     Source-specificity    

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Investigating the role of exiting vehicles and turn indicator usage in gap acceptance at single-lane

Nathan P. BELZ

《结构与土木工程前沿（英文）》 2017年 第11卷 第1期   页码 8-16 doi: 10.1007/s11709-016-0365-7

摘要： Roundabouts are becoming a preferred form of intersection control type due to their safety and capacity benefits. Yield control at roundabout entries inherently reduces fuel consumption and emissions when compared to other conventional intersection types. However, these benefits can be limited by poor driver behavior and judgment when entering the roundabout. This research addresses the nature of gap distributions and use of turn indicators by exiting vehicles at three single-lane roundabouts in Vermont, New York, and Alaska. Presented here is a comparison of vehicle headways measured at two different locations in each roundabout. Rejected headways are analyzed in the context of priority abstaining events when entering drivers yield to vehicles exiting on the same leg of the roundabout suggesting that “true” critical gaps are being overestimated. Results indicate that exiting vehicles, particularly those that do not use their turn indicators when departing from the major-stream of traffic have an influence on the entry decision of drivers on the same approach. This behavior is of particular concern for intersection efficiency (i.e., delay) and sustainability (i.e., excess fuel consumption and emissions). Results prompt the consideration of more consistent guidance on and enforcement of turn indicator use during roundabout negotiations.

关键词： roundabouts     exiting vehicles     turn indicator use     headways    

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Modeling effects of a tidal barrage on water quality indicator distribution in the Severn Estuary

Guanghai GAO, Roger A. FALCONER, Binliang LIN

《环境科学与工程前沿（英文）》 2013年 第7卷 第2期   页码 211-218 doi: 10.1007/s11783-012-0464-1

摘要： In this study, emphasis has focused on assessing the potential hydro-environmental impacts of a barrage across the Severn Estuary, with a numerical model being developed and applied to the estuary to assess the impacts of proposed Severn Barrage on the hydrodynamic, sediment transport and faecal indicator organism distribution within the estuary. The results show that the Severn Barrage has the potential to reduce the tidal currents in a highly dynamic estuary. This leads to the reduction of suspended sediment concentrations, which in turn affects the bacterial transport processes which is highly related to the sediment transport processes.

关键词： water quality indicator     Severn Estuary     numerical model     tidal energy    

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Water environment security indicator system for urban water management

Tian HAO, Pengfei DU, Yun GAO

《环境科学与工程前沿（英文）》 2012年 第6卷 第5期   页码 678-691 doi: 10.1007/s11783-012-0450-7

摘要： Water environment security (WES) is defined in terms of three aspects: first, that it meets basic demands due to industrial and domestic usage; second, that it protects public health from acute and chronic threats; and third, that measures are adopted to ensure sustainable ecological functioning of freshwater resources. Limitations associated with current water environment security indicators in China — including inefficiency in terms of environmental monitoring, inappropriate indicators and parameters that do not take sufficient account of local water characteristics, and a lack of management targets — leads to a failure of effective water management. To achieve better water environment management, a systematic approach, encompassing several steps including establish ideal indicator system and narrow down the scope, screen priority pollutants, identify local characteristics and organize discussion workshop, should be followed to establish a comprehensive water environment indicator system. A case study in Suzhou is included to demonstrate the detailed operational procedures used to assess the risks associated with poor management practices relating to water environment security as well as design an appropriate water environment security indicator system.

关键词： water environment security     supervision and management     monitoring parameter     indicator system     Suzhou    

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China’s Agriculture Green Development: from Concept to Actions RESEARCH ARTICLE

《农业科学与工程前沿（英文）》 2024年 第11卷 第1期   页码 20-34 doi: 10.15302/J-FASE-2023512

摘要：

China has initiated a green transformation plan in 2015, which was soon applied to agriculture, known as the Agriculture Green Development (AGD) initiative, with the goals of achieving food security, high resource use efficiency, and an ecofriendly environment. To assess the agricultural transformation from 1997 to 2020, this paper proposes a national-scale indicator system consisting three dimensions (socioeconomic, food production and eco-environmental) and ten sub-dimensions to quantify the AGD score. This study showed that AGD score in China was at a moderate level during 1997–2010, scoring 40 out of 100. During this stage, decreased scores in the sub-dimensions of resource consumption, environmental quality, and environmental cost have offset the improvement in the socioeconomic dimension, resulting in fluctuated scores around 40. In the second stage (2011–2020), China’s AGD score improved but still at moderate level, scoring an average of 46.3, with each dimension increasing by 5.3%–25.0%. These results indicate that China has made progress in the agricultural transformation, transitioning from conceptualization to actions through the implementation of various policies and projects. However, the study emphasizes the need for more effort to address the insufficient and unbalanced development, along with the growing eco-environmental challenges, especially the trade-offs among dimensions.

关键词： agricultural transformation     Agriculture Green Development     historical trend     indicator system     theoretical conception    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

null

《医学前沿（英文）》 2016年 第10卷 第1期   页码 41-51 doi: 10.1007/s11684-016-0429-z

摘要：

Midline2 (MID2) is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breast cancer 1, early-onset (BRCA1). However, the role of MID2 in breast cancer remains unknown. This study investigated the expression, prognostic value, and role of MID2 in breast cancer. The expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and established cell lines compared with that in normal breast epithelial cells and paired adjacent non-tumor tissue (P<0.001). Immunohistochemical analysis demonstrated that MID2 was overexpressed in 272 of 284 (95.8%) paraffin-embedded, archived breast cancer tissue. Moreover, MID2 expression increased with advanced clinical stage (P<0.001). High MID2 expression was significantly associated with advanced clinical stages and T, N, and M staging (all P<0.05). Univariate and multivariate analyses indicated that high MID2 expression was an independent prognostic factor for poor overall survival in the entire cohort (93.73 vs. 172.1 months; P<0.001, log-rank test) and in subgroups with stages Tis+ I+ II and III+ IV. Furthermore, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide colony formation, and anchorage-independent growth ability assays were conducted. Results showed that siRNA silencing of MID2 expression significantly reduced MCF-7 and MDA-MB-231 cell proliferation in vitro and blocked the growth of MDA-MB-231 cell xenograft tumors in vivo (P<0.05). This study indicated that MID2 may be a novel prognostic marker and interventional target in breast cancer.

关键词： breast cancer     MID2     proliferation     overall survival     xenograft    

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Nonlinear dynamic behavior of rotating blade with breathing crack

Laihao YANG, Zhu MAO, Shuming WU, Xuefeng CHEN, Ruqiang YAN

《机械工程前沿（英文）》 2021年 第16卷 第1期   页码 196-220 doi: 10.1007/s11465-020-0609-z

摘要： This study aims at investigating the nonlinear dynamic behavior of rotating blade with transverse crack. A novel nonlinear rotating cracked blade model (NRCBM), which contains the spinning softening, centrifugal stiffening, Coriolis force, and crack closing effects, is developed based on continuous beam theory and strain energy release rate method. The rotating blade is considered as a cantilever beam fixed on the rigid hub with high rotating speed, and the crack is deemed to be open and close continuously in a trigonometric function way with the blade vibration. It is verified by the comparison with a finite element-based contact crack model and bilinear model that the proposed NRCBM can well capture the dynamic characteristics of the rotating blade with breathing crack. The dynamic behavior of rotating cracked blade is then investigated with NRCBM, and the nonlinear damage indicator (NDI) is introduced to characterize the nonlinearity caused by blade crack. The results show that NDI is a distinguishable indicator for the severity level estimation of the crack in rotating blade. It is found that severe crack (i.e., a closer crack position to blade root as well as larger crack depth) is expected to heavily reduce the stiffness of rotating blade and apparently result in a lower resonant frequency. Meanwhile, the super-harmonic resonances are verified to be distinguishable indicators for diagnosing the crack existence, and the third-order super-harmonic resonances can serve as an indicator for the presence of severe crack since it only distinctly appears when the crack is severe.

关键词： rotating blade     breathing crack     nonlinear vibration     nonlinear damage indicator    

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of the situational awareness effects for smart distribution networks under the novel design of indicator

Leijiao GE, Yuanliang LI, Suxuan LI, Jiebei ZHU, Jun YAN

《能源前沿（英文）》 2021年 第15卷 第1期   页码 143-158 doi: 10.1007/s11708-020-0703-2

摘要： As a key application of smart grid technologies, the smart distribution network (SDN) is expected to have a high diversity of equipment and complexity of operation patterns. Situational awareness (SA), which aims to provide a critical visibility of the SDN, will enable a significant assurance for stable SDN operations. However, the lack of systematic evaluation through the three stages of perception, comprehensive, and prediction may prevent the SA technique from effectively achieving the performance necessary to monitor and respond to events in SDN. To analyze the feasibility and effectiveness of the SA technique for the SDN, a comprehensive evaluation framework with specific performance indicators and systematic weighting methods is proposed in this paper. Besides, to implement the indicator framework while addressing the key issues of human expert scoring ambiguity and the lack of data in specific SDN areas, an improved interval-based analytic hierarchy process-based subjective weighting and a multi-objective programming method-based objective weighting are developed to evaluate the SDN SA performance. In addition, a case study in a real distribution network of Tianjin China is conducted whose outcomes verify the practicality and effectiveness of the proposed SA technique for SDN operating security.

关键词： distribution networks     operation and maintenance     expert systems    

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Effect of streambed substrate on macroinvertebrate biodiversity

DUAN Xuehua, WANG Zhaoyin, TIAN Shimin

《环境科学与工程前沿（英文）》 2008年 第2卷 第1期   页码 122-128 doi: 10.1007/s11783-008-0023-y

摘要： Macroinvertebrates are important components of stream ecosystems, and are often used as indicator species for the assessment of river ecology. Numerous studies have shown that substrate is the primary physical environmental variable affecting the taxa richness and density of macroinvertebrates. The aim of this work is to study the effects of the characteristics of streambed substrate, such as grain size, shape, and roughness, on the composition and biodiversity of macroinvertebrates. A field experiment was done on the Juma River, a second-order mountain stream in northern China. Substrata of cobbles, hewn stones, pebbles, coarse sand, and fine sand were used to replace the original gravel and sand bed in a stretch of 30 m in length. The sampling results indicated that the macroinvertebrate assemblage is significantly affected by the grain size, porosity and interstitial dimension of the substrate, while it is rarely affected by the shape and the surface roughness of the experimental substrata. Macroinvertebrate compositions in cobbles and hewn stones were stable and changed least over time. The taxa richness and density of individuals in the substrata of cobbles, hewn stones, and pebbles are much higher than in those of the coarse sand and fine sand.

关键词： Substrata     physical environmental     indicator     ecology     substrate    

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基于海面更快区域卷积神经网络的导航雷达平面位置指示器图像海面目标检测方法 Research Article

陈小龙,牟效乾,关键,刘宁波,周伟

《信息与电子工程前沿（英文）》 2022年 第23卷 第4期   页码 630-643 doi: 10.1631/FITEE.2000611

摘要： 更快的区域卷积神经网络（Faster R-CNN）作为一种经典深度学习目标检测算法，已广泛应用于高分辨率合成孔径雷达和逆合成孔径雷达的图像检测。然而，对于大多数常见的低分辨率雷达平面位置指示器（PPI）图像，很难取得良好性能。本文以导航雷达PPI图像为例，针对复杂背景（如海杂波）和目标特性情况，提出一种基于海面的更快的区域卷积神经网络（Marine-Faster R-CNN）算法的海面目标检测方法。该方法利用卷积神经网络（CNN）对雷达回波生成的PPI图像进行特征提取和目标识别。首先，为提高检测海面目标的准确率，降低虚警率，设计了特征融合网络FFNet（Feature Fusion Network），并从锚点尺度、多目标检测、数据样本平衡性、尺度归一化等方面优化Faster R-CNN，并基于此建立Marine-Faster R-CNN海面目标检测模型。然后，利用日本无线电株式会社（JRC）导航雷达采集不同条件下的回波数据，构建海面目标数据集。最后，与经典Faster R-CNN方法和恒虚警率算法对比，证明所提方法准确率更高，稳健性更佳，泛化能力更强，可应用于导航雷达海面目标检测。它的性能经过了来自不同观测条件（海况、雷达参数和不同目标）数据集的验证。

关键词： 海面目标检测；导航雷达；平面位置指示器（PPI）图像；卷积神经网络；更快的区域卷积神经网络    

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SUSTAINABLE NITROGEN MANAGEMENT INDEX: DEFINITION, GLOBAL ASSESSMENT AND POTENTIAL IMPROVEMENTS

《农业科学与工程前沿（英文）》 2022年 第9卷 第3期   页码 356-365 doi: 10.15302/J-FASE-2022458

摘要：

● A composite N management index is proposed to measure agriculture sustainability.

关键词： global assessment     indicator     nitrogen management     sustainable agriculture     sustainable development goals    

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Comparison of indicators for agricultural green development and the Sustainable Development Goals, and mapping the way forward RESEARCH ARTICLE

《农业科学与工程前沿（英文）》 2024年 第11卷 第1期   页码 69-82 doi: 10.15302/J-FASE-2024548

摘要：

While agricultural green development (AGD) is highly recognized and has become a national strategy in China, it is imperative to bridge the knowledge gaps between AGD and the UN Sustainable Development Goals (SDGs), and to evaluate the contribution of AGD to meeting the SDGs. The first aim of this study was to compare the AGD goals and indicators with those of the SDGs so as to identify their relationship. The next aim was to examine the historical evolution of AGD indicators and analyze the gaps between the current status of various indicators and their benchmarks. Limiting factors were identified in China’s transition toward AGD. These findings reveal that the indicators of AGD align with those of the SDGs, but have greater specificity to the context in China and are more quantifiable. There has been a significant increase per capita calorie and protein intakes in China, as well as a notable rise in agricultural output per unit of arable land and rural incomes from 1980 to the 2010s. However, these achievements have been accompanied by a high resource use and environmental pollution, highlighting the need for a more sustainable, environmentally responsible agriculture in China.

关键词： Agricultural green development     sustainable development goals     environmental sustainability     indicator system     optimization pathway    

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过氧化氢作为环境胁迫指标在植被管理中的应用 Article

Takashi Asaeda, Senavirathna Mudalige Don Hiranya Jayasanka, Li-Ping Xia, Abner Barnuevo

《工程（英文）》 2018年 第4卷 第5期   页码 610-616 doi: 10.1016/j.eng.2018.09.001

摘要：

适应性植被管理非常耗时，其需要长时间的野外监测以获取可靠的数据。目前适应性植被管理手段虽已被广泛应用，但在进行栖息地状况评估时，仍然依赖于长时间的野外观测。目前的植被相关研究中，活性氧类（ROS）已经被视为一种环境胁迫指标。在这些ROS中，过氧化氢（H2O2）相对稳定，并且可以被准确、方便地量化。植物中H2O2含量可以被用作岸生和水生植被管理过程的胁迫指标，同时可以用来评估栖息地中单一植物物种的生长状况。本研究证明了植被管理中应用H2O2作为定量化环境胁迫指标的可行性。在实验室和野外（日本的真嗣湖、沙巴河、伊诺河和海河）条件下，分别开展了不同胁迫程度下大型水生植物和岸生植物生成H2O2情况的研究，结果表明H2O2可以作为环境管理中的胁迫指标。

关键词： 大型植物     河岸边区域     环境梯度     胁迫指标     活性氧类     过氧化氢    

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Smart model for accurate estimation of solar radiation

Lazhar ACHOUR, Malek BOUHARKAT, Ouarda ASSAS, Omar BEHAR

《能源前沿（英文）》 2020年 第14卷 第2期   页码 383-399 doi: 10.1007/s11708-017-0505-3

摘要： Prediction of solar radiation has drawn increasing attention in the recent years. This is because of the lack of solar radiation measurement stations. In the present work, 14 solar radiation models have been used to assess monthly global solar radiation on a horizontal surface as function of three parameters: extraterrestrial solar irradiance ( ), duration sunshine ( ) and daylight hours ( ). Since it has been observed that each model is adequate for some months of the year, one model cannot be used for the prediction of the whole year. Therefore, a smart hybrid system is proposed which selects, based on the intelligent rules, the most suitable prediction model of the 14 models listed in this study. For the test and evaluation of the proposed models, Tamanrasset city, which is located in the south of Algeria, is selected for this study. The meteorological data sets of five years (2000–2004) have been collected from the Algerian National Office of Meteorology (NOM), and two spatial databases. The results indicate that the new hybrid model is capable of predicting the monthly global solar radiation, which offers an excellent measuring accuracy of values ranging from 93% to 97% in this location.

关键词： global solar radiation     statistical indicator     hybrid model     spatial database     correlation coefficients    

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标题 作者 时间 类型 操作

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

期刊论文

Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study

期刊论文

Investigating the role of exiting vehicles and turn indicator usage in gap acceptance at single-lane

Nathan P. BELZ

期刊论文

Modeling effects of a tidal barrage on water quality indicator distribution in the Severn Estuary

Guanghai GAO, Roger A. FALCONER, Binliang LIN

期刊论文

Water environment security indicator system for urban water management

Tian HAO, Pengfei DU, Yun GAO

期刊论文

China’s Agriculture Green Development: from Concept to Actions

期刊论文

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

null

期刊论文

Nonlinear dynamic behavior of rotating blade with breathing crack

Laihao YANG, Zhu MAO, Shuming WU, Xuefeng CHEN, Ruqiang YAN

期刊论文

of the situational awareness effects for smart distribution networks under the novel design of indicator

Leijiao GE, Yuanliang LI, Suxuan LI, Jiebei ZHU, Jun YAN

期刊论文

Effect of streambed substrate on macroinvertebrate biodiversity

DUAN Xuehua, WANG Zhaoyin, TIAN Shimin

期刊论文

基于海面更快区域卷积神经网络的导航雷达平面位置指示器图像海面目标检测方法

陈小龙,牟效乾,关键,刘宁波,周伟

期刊论文

SUSTAINABLE NITROGEN MANAGEMENT INDEX: DEFINITION, GLOBAL ASSESSMENT AND POTENTIAL IMPROVEMENTS

期刊论文

Comparison of indicators for agricultural green development and the Sustainable Development Goals, and mapping the way forward

期刊论文

过氧化氢作为环境胁迫指标在植被管理中的应用

Takashi Asaeda, Senavirathna Mudalige Don Hiranya Jayasanka, Li-Ping Xia, Abner Barnuevo

期刊论文

Smart model for accurate estimation of solar radiation

Lazhar ACHOUR, Malek BOUHARKAT, Ouarda ASSAS, Omar BEHAR

期刊论文