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Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation

《医学前沿（英文）》 2023年第17卷第2期页码 339-351 doi: 10.1007/s11684-022-0943-0

摘要： Ketone bodies have beneficial metabolic activities, and the induction of plasma ketone bodies is a health promotion strategy. Dietary supplementation of sodium butyrate (SB) is an effective approach in the induction of plasma ketone bodies. However, the cellular and molecular mechanisms are unknown. In this study, SB was found to enhance the catalytic activity of 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), a rate-limiting enzyme in ketogenesis, to promote ketone body production in hepatocytes. SB administrated by gavage or intraperitoneal injection significantly induced blood β-hydroxybutyrate (BHB) in mice. BHB production was induced in the primary hepatocytes by SB. Protein succinylation was altered by SB in the liver tissues with down-regulation in 58 proteins and up-regulation in 26 proteins in the proteomics analysis. However, the alteration was mostly observed in mitochondrial proteins with 41% down- and 65% up-regulation, respectively. Succinylation status of HMGCS2 protein was altered by a reduction at two sites (K221 and K358) without a change in the protein level. The SB effect was significantly reduced by a SIRT5 inhibitor and in Sirt5-KO mice. The data suggests that SB activated HMGCS2 through SIRT5-mediated desuccinylation for ketone body production by the liver. The effect was not associated with an elevation in NAD⁺/NADH ratio according to our metabolomics analysis. The data provide a novel molecular mechanism for SB activity in the induction of ketone body production.

关键词： sodium butyrate succinylation HMGCS2 ketogenesis SIRT5

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matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2

《医学前沿（英文）》 2021年第15卷第5期页码 750-766 doi: 10.1007/s11684-021-0839-4

摘要： Exposure to particulate matter 2.5 (PM2.5) potentially triggers airway inflammation by activating nuclear factor-κB (NF-κB). Sirtuin 2 (SIRT2) is a key modulator in inflammation. However, the function and specific mechanisms of SIRT2 in PM2.5-induced airway inflammation are largely understudied. Therefore, this work investigated the mechanisms of SIRT2 in regulating the phosphorylation and acetylation of p65 influenced by PM2.5-induced airway inflammation and bronchial hyperresponsiveness. Results revealed that PM2.5 exposure lowered the expression and activity of SIRT2 in bronchial tissues. Subsequently, SIRT2 impairment promoted the phosphorylation and acetylation of p65 and activated the NF-κB signaling pathway. The activation of p65 triggered airway inflammation, increment of mucus secretion by goblet cells, and acceleration of tracheal stenosis. Meanwhile, p65 phosphorylation and acetylation, airway inflammation, and bronchial hyperresponsiveness were deteriorated in SIRT2 knockout mice exposed to PM2.5. Triptolide (a specific p65 inhibitor) reversed p65 activation and ameliorated PM2.5-induced airway inflammation and bronchial hyperresponsiveness. Our findings provide novel insights into the molecular mechanisms underlying the toxicity of PM2.5 exposure. Triptolide inhibition of p65 phosphorylation and acetylation could be an effective therapeutic approach in averting PM2.5-induced airway inflammation and bronchial hyperresponsiveness.

关键词： particulate matter 2.5 sirtuin 2 p65 airway inflammation bronchial hyperresponsiveness triptolide

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基于 5G技术的教育信息化应用研究

卢向群,孙禹

《中国工程科学》 2019年第21卷第6期页码 120-128 doi: 10.15302/J-SSCAE-2019.06.020

摘要：

教育信息化日益普及，智慧学习空间不断出现，学生对学习内容的个性化、便捷化、多样化需求也日益凸显，而第五代移动通信（ 5G）技术以其大带宽、本文重点探索 5G技术的教育信息化应用，在梳理教育信息化主要特征的基础上，分析了我国教育网络面临的技术挑战，从教学、教研、教育管理三方面着手，论证提出相应的 5G应用场景，形成 5G教育信息化总体视图。面向 2035年， 5G的技术普及与应用拓展，将不断丰富教育场景的内涵，推动教育场景的变革，成为我国教育信息化创新的原生动力。

关键词：教育信息技术教育信息化 5G 技术应用场景

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5G应用下的MIMO阵列天线去耦方法综述 Review Articles

Xiao-xi ZHANG, Ai-di REN, Ying LIU

《信息与电子工程前沿（英文）》 2020年第21卷第1期页码 62-71 doi: 10.1631/FITEE.1900466

摘要：提出一种面向微纳卫星的自主汽化管理液氨推进系统。相比常规冷气或液化气推进系统，提出多路平行筛孔式汽化装置和对应汽化控制方法。所提方案有效解决了液氨高汽化潜热和不易完全汽化的问题，从而发挥液氨推进剂高贮存密度和高比冲性能优势。此外，重点分析自主汽化管理液氨推进系统的工作流程及其涉及的物理化学过程和数学模型。综合考虑推力表现和能源效率，提出最优系统推力控制策略。地面测试表明，自主汽化管理液氨推进系统总重1.8 kg（包含0.34 kg液氨推进剂），比冲达到100 s，系统功耗在10 W以下。自主汽化管理液氨推进系统具有高比冲、低功耗、可实现性强、推力输出均一稳定等特点，适合微纳卫星在轨应用。

关键词： MIMO阵列；5G手机；去耦方法

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

《医学前沿（英文）》 2023年第17卷第2期页码 317-329 doi: 10.1007/s11684-022-0931-4

摘要： Long noncoding RNAs (lncRNAs) play a critical role in the regulation of atherosclerosis. Here, we investigated the role of the lncRNA growth arrest-specific 5 (lncR-GAS5) in atherogenesis. We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis, which presented as increased plaque size and reduced collagen content. Moreover, impaired autophagy was observed, as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells. By contrast, lncR-GAS5 knockdown promoted autophagy. Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3I ratio and decreased the P62 level, thus enhancing the formation of autophagic vacuoles, autolysosomes, and autophagosomes. Mechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium, which was reversed by the knockdown of SRSF10. Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene, SRSF10. Notably, miR-193-5p overexpression decreased plaque size and increased collagen content. Altogether, these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy. In conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway. Thus, miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

关键词： lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis

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2020普遍通信与5G技术国际会议(UC5G 2020)

会议日期： 2020年03月26日

会议地点：上海

主办单位： APISE

5G综述及中国的进展 None

Shan-zhi CHEN, Shao-li KANG

《信息与电子工程前沿（英文）》 2018年第19卷第3期页码 309-321 doi: 10.1631/FITEE.1800070

摘要： 5G技术、标准和产业化从20012年开始高速发展，是全球经济新的驱动力。本文全面介绍了5G，包括愿景、要求、演进、关键技术、标准化、频谱分配、技术试验、产业化进展和5G主要贡献者。同时指出，中国企业作为5G主要技术和标准的贡献者，正处于“5G引领”过程中。最后介绍了5G最新进展和作者关于5G的再思考。

关键词： 5G；IMT-2020；关键技术；标准；现场试验

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Boehmite-supported CuO as a catalyst for catalytic transfer hydrogenation of 5-hydroxymethylfurfural

《化学科学与工程前沿（英文）》 2023年第17卷第4期页码 415-424 doi: 10.1007/s11705-022-2225-4

摘要： 2,5-bis(hydroxymethyl)furan (BHMF) is an important monomer of polyester. Its oxygen-containing rigid ring structure and symmetrical diol functional group establish it as an alternative to petroleum-based monomer with unique advantages for the prodution of the degradable bio-based polyester materials. Herein, we prepared a boehmite-supported copper-oxide catalyst for the selective hydrogenation of 5-hydroxymethylfurfural into BHMF via catalytic transfer hydrogenation (CTH). Further, ethanol successfully replaced conventional high-pressure hydrogen as the hydrogen donor, with up to 96.9% BHMF selectivity achieved under suitable conditions. Through characterization and factor investigations, it was noted that CuO is crucial for high BHMF selectivity. Furthermore, kinetic studies revealed a higher by-product activation energy compared to that of BHMF, which explained the influence of reaction temperature on product distribution. To establish the catalyst structure-activity correlation, a possible mechanism was proposed. The copper-oxide catalyst deactivated following CTH because ethanol reduced the CuO, which consequently decreased the active sites. Finally, calcination of the catalyst in air recovered its activity. These results will have a positive impact on hydrogenation processes in the biomass industry.

关键词： biomass 5-hydroxymethylfurfural 2 5-bis(hydroxymethyl)furan transfer hydrogenation catalysis

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一场潜在的5G干扰风暴

Chris Palmer

《工程（英文）》 2019年第5卷第5期页码 815-816 doi: 10.1016/j.eng.2019.08.007

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2020年5G移动通信与信息科学国际学术会议（MCIS-5G2020）

会议日期： 2020年06月26日

会议地点：广东广州

Management innovation of Chang’e-5 project

《工程管理前沿（英文）》 2021年第8卷第4期页码 620-626 doi: 10.1007/s42524-021-0165-1

关键词： lunar exploration sample return systems engineering project management

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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial

《医学前沿（英文）》 doi: 10.1007/s11684-023-0993-y

摘要： Metastases of uveal melanoma (UM) spread predominantly to the liver. Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for tumor control. The impact of LDT on the response to systemic treatment is unknown. A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were included in this analysis. Patients were recruited from prospective skin cancer centers and the German national skin cancer registry (ADOReg) of the German Dermatologic Cooperative Oncology Group (DeCOG). Two cohorts were compared: patients with LDT (cohort A, n = 78) versus those without LDT (cohort B, n = 104). Data were analyzed for response to treatment, progression-free survival (PFS), and overall survival (OS). The median OS was significantly longer in cohort A than in cohort B (20.1 vs. 13.8 months; P = 0.0016) and a trend towards improved PFS was observed for cohort A (3.0 vs. 2.5 months; P = 0.054). The objective response rate to any ICB (16.7% vs. 3.8%, P = 0.0073) and combined ICB (14.1% vs. 4.5%, P = 0.017) was more favorable in cohort A. Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM.

关键词： uveal melanoma liver-directed therapy immune checkpoint blockade SIRT anti-PD-1 anti-CTLA-4

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Thermoresponsive block copolymer supported Pt nanocatalysts for base-free aerobic oxidation of 5-hydroxymethyl

《化学科学与工程前沿（英文）》 2021年第15卷第6期页码 1514-1523 doi: 10.1007/s11705-021-2092-4

摘要： A base-free catalytic system for the aerobic oxidation of 5-hydroxymethyl-2-furfural was exploited by using Pt nanoparticles immobilized onto a thermoresponsive poly(acrylamide-co-acrylonitrile)-b-poly(N-vinylimidazole) block copolymer, with an upper critical solution temperature of about 45 °C. The Pt nanocatalysts were well-dispersed and highly active for the base-free oxidation of 5-hydroxymethyl-2-furfural by molecular oxygen in water, affording high yields of 2,5-furandicarboxylic acid (up to>99.9%). The imidazole groups in the block copolymer were conducive to the improvement of catalytic performance. Moreover, the catalysts could be easily separated and recovered based on their thermosensitivity by cooling the reaction system below the upper critical solution temperature. Good stability and reusability were observed over these copolymer-immobilized catalysts with no obvious decrease in catalytic activity in the five consecutive cycles.

关键词： aerobic oxidation base-free 5-hydroxymethyl-2-furfural Pt nanoparticle thermoresponsive block copolymer

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Catalytic hydrogenation of insoluble organic matter of CS/Acetone from coal over mesoporous HZSM-5 supported

《化学科学与工程前沿（英文）》 2022年第16卷第10期页码 1505-1513 doi: 10.1007/s11705-022-2164-0

摘要： Four supported catalysts, nickel and ruthenium on a HZSM-5 support, were prepared by equal volume impregnation and in-situ decomposition of carbonyl nickel. The properties of catalysts were investigated by catalytic hydro-conversion of 2,2′-dinaphthyl ether as the model compound and extraction residue of Naomaohu lignite as the sample under an initial H₂ pressure of 5 MPa and temperature at 150 °C. According to the catalytic hydro-conversion results of the model compound, Ni−Ru/HZSM-5 exhibited the best catalytic performance. It not only activated H₂ into H···H, but also further heterolytically split H···H into immobile H^‒ attached on the acidic centers of Ni−Ru/HZSM-5 and relatively mobile H⁺. Catalytic hydro-conversion of the extraction residue from Naomaohu lignite was further examined over the optimized catalyst, Ni−Ru/HZSM-5. Detailed molecular compositions of products from the extraction residue with and without hydrogenation were characterized by Fourier transform infrared spectroscopy and gas chromatography/mass spectrometry. The analytical results showed that the oxygen-containing functional groups in products of hydrogenated extraction residue were obviously reduced after the catalytic treatment. The relative content of oxygenates in the product with catalytic treatment was 18.57% lower than that in the product without catalytic treatment.

关键词： HZSM-5 Ni-based catalyst catalytic hydrogenation coal model compound

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Methanol to propylene: the effect of iridium and iron incorporation on the HZSM-5 catalyst

Alireza MOHAMMADREZAEI, Sadegh PAPARI, Mousa ASADI, Abas NADERIFAR, Reza GOLHOSSEINI

《化学科学与工程前沿（英文）》 2012年第6卷第3期页码 253-258 doi: 10.1007/s11705-012-0902-4

摘要： The effect of iridium and iron impregnation of HZSM-5 zeolite on the methanol to propylene reaction (MTP) was investigated. The selectivities of propylene and other hydrocarbons, and the conversion of methanol were compared by performing MTP in a small pilot plant. The results indicate that HZSM-5 zeolite modified by iron and iridium increased propylene selectivity by 6.3% and 8%, respectively. The selectivity of propylene was higher for Ir/H-ZSM-5 than for Fe/H-ZSM-5, where Fe/H-ZSM-5 was more stable than Ir/H-ZSM-5. Analytic techniques, including X-ray diffraction, BET surface area, temperature-programmed desorption of ammonia, and inductively coupled plasma atomic emission spectroscopy, were used to characterize the modified zeolites as well as the parent zeolites.

关键词： HZSM-5 promoter iridium iron MTP

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标题作者时间类型操作

Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation

期刊论文

matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating the SIRT2

期刊论文

基于 5G技术的教育信息化应用研究

卢向群,孙禹

期刊论文

5G应用下的MIMO阵列天线去耦方法综述

Xiao-xi ZHANG, Ai-di REN, Ying LIU

期刊论文

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

期刊论文

2020普遍通信与5G技术国际会议(UC5G 2020)

2020年03月26日

会议信息

5G综述及中国的进展

Shan-zhi CHEN, Shao-li KANG

期刊论文

Boehmite-supported CuO as a catalyst for catalytic transfer hydrogenation of 5-hydroxymethylfurfural

期刊论文

一场潜在的5G干扰风暴

Chris Palmer

期刊论文

2020年5G移动通信与信息科学国际学术会议（MCIS-5G2020）

2020年06月26日

会议信息

Management innovation of Chang’e-5 project

期刊论文

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma: results from a retrospective multicenter trial

期刊论文

Thermoresponsive block copolymer supported Pt nanocatalysts for base-free aerobic oxidation of 5-hydroxymethyl

期刊论文

Catalytic hydrogenation of insoluble organic matter of CS/Acetone from coal over mesoporous HZSM-5 supported

期刊论文

Methanol to propylene: the effect of iridium and iron incorporation on the HZSM-5 catalyst

Alireza MOHAMMADREZAEI, Sadegh PAPARI, Mousa ASADI, Abas NADERIFAR, Reza GOLHOSSEINI

期刊论文

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