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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells
LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan
《医学前沿(英文)》 2007年 第1卷 第3期 页码 269-273 doi: 10.1007/s11684-007-0051-1
关键词: 3T3-L1 influence resistance receptor substrate-1 transport
Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN
《化学科学与工程前沿(英文)》 2012年 第6卷 第3期 页码 339-347 doi: 10.1007/s11705-012-1209-1
关键词: cryogel scaffold tissue engineering dextran hyaluronate 3T3-L1 preadipocyte
PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa
《医学前沿(英文)》 2008年 第2卷 第3期 页码 259-263 doi: 10.1007/s11684-008-0049-3
CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 554-562 doi: 10.1007/s11684-017-0543-6
T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.
关键词: CAR-T CRISPR-Cas9 LAG-3
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
Shi-Yong Sun
《医学前沿(英文)》 2021年 第15卷 第2期 页码 221-231 doi: 10.1007/s11684-020-0812-7
关键词: mTOR cancer therapy resistance GSK3 protein degradation E3 ubiquitin ligase PD-L1
An extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3) for free vibration analysis
NGUYEN-THOI,L. Le-ANH,V. Ho-HUU,H. Dang-TRUNG,T. NGUYEN-THOI
《结构与土木工程前沿(英文)》 2015年 第9卷 第4期 页码 341-358 doi: 10.1007/s11709-015-0302-1
关键词: cracked Reissner-Mindlin shell free vibration analysis cell-based smoothed discrete shear gap method (CS-FEM-DSG3) extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3) smoothed finite element methods (SFEM)
《医学前沿(英文)》 doi: 10.1007/s11684-023-1003-0
关键词: Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
《医学前沿(英文)》 2022年 第16卷 第1期 页码 150-155 doi: 10.1007/s11684-021-0846-5
基于玻璃通孔的Ka波段宽带滤波封装天线 Research Article
方针1,2,张继华1,2,3,高莉彬1,2,陈宏伟1,2,李文磊1,2,梁天鹏1,2,蔡旭东1,2,蔡星周3,贾惟聪3,郭欢3,李勇3
《信息与电子工程前沿(英文)》 2023年 第24卷 第6期 页码 916-926 doi: 10.1631/FITEE.2200573
APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Drought stress typically causes heavy losses in apple production and uncovering the mechanisms by which apple tolerates drought stress is important in apple breeding. MdSIZ1 is a SUMO (small ubiquitin-like modifier) E3 ligase that promotes SUMO binding to substrate proteins. Here, we demonstrate that MdSIZ1 in apple has a negative relationship with drought tolerance. MdSIZ1 RNAi transgenic apple trees had a higher survival rate after drought stress. During drought stress they had higher leaf water potential, reduced ion leakage, lower H2O2 and malondialdehyde contents, and higher catalase activity. In addition, MdSIZ1 RNAi transgenic plants had a higher net photosynthetic rate during the latter period of drought stress. Finally, the transgenic apple trees also altered expression levels of some microRNAs in response to drought stress. Taken together, these results indicate that apple MdSIZ1 negatively regulates drought stress by enhancing leaf water-holding capacity and antioxidant enzyme activity.
用以产生高纯度涡旋波束的宽带圆极化透射阵 Correspondence
邱靓婕1,2,3,4,李秀萍1,2,3,4,齐紫航1,2,3,4,赵文禹1,2,3,4,黄雨菡5
《信息与电子工程前沿(英文)》 2023年 第24卷 第6期 页码 927-934 doi: 10.1631/FITEE.2200539
Self-motions of 3-RPS manipulators
Josef SCHADLBAUER, Manfred L. HUSTY, Stéphane CARO, Philippe WENGERY
《机械工程前沿(英文)》 2013年 第8卷 第1期 页码 62-69 doi: 10.1007/s11465-013-0366-3
Recently a complete kinematic description of the 3-RPS parallel manipulator was obtained using algebraic constraint equations. It turned out that the workspace splits into two components describing two kinematically different operation modes. In this paper the algebraic description is used to give a complete analysis of all possible self-motions of this manipulator in both operation modes. Furthermore it is shown that a transition from one operation mode into the other in a self-motion is possible.
APPLE SUMO E3 LIGASE MDSIZ1 NEGATIVELY REGULATES DROUGHT TOLERANCE
《农业科学与工程前沿(英文)》 2021年 第8卷 第4期 页码 662-662 doi: 10.15302/J-FASE-2021408
《医学前沿(英文)》 2022年 第16卷 第6期 页码 883-895 doi: 10.1007/s11684-022-0919-0
关键词: osteosarcoma autophagy metastasis drug resistance Beclin1 LC3B
标题 作者 时间 类型 操作
Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells
LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan
期刊论文
Cryo-copolymerization preparation of dextran-hyaluronate based supermacroporous cryogel scaffolds for tissue engineering applications
Dongjiao ZHOU, Shaochuan SHEN, Junxian YUN, Kejian YAO, Dong-Qiang LIN
期刊论文
randomized trials of maintenance bacillus Calmette-Guerin instillation efficacy against recurrence of T1G3
PAN Jiangang, ZHOU Xing, CHEN Zhiguang, HAN Ruifa
期刊论文
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
Shi-Yong Sun
期刊论文
An extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3) for free vibration analysis
NGUYEN-THOI,L. Le-ANH,V. Ho-HUU,H. Dang-TRUNG,T. NGUYEN-THOI
期刊论文
Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression andhypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1
期刊论文
Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient
期刊论文
虞晓含:中医话健康,食补改善免疫力(2020年3月1日)
2022年04月18日
会议视频
Self-motions of 3-RPS manipulators
Josef SCHADLBAUER, Manfred L. HUSTY, Stéphane CARO, Philippe WENGERY
期刊论文