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Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu
《医学前沿(英文)》 2021年 第15卷 第4期 页码 585-593 doi: 10.1007/s11684-020-0817-2
关键词: Stevens–Johnson syndrome toxic epidermal necrolysis auxiliary score ABCD-10 pulmonary consolidation
PM10 emissions from industrial coal-fired chain-grate boilers
Xinghua Li, Junzan Han, Lei Duan
《环境科学与工程前沿(英文)》 2017年 第11卷 第6期 doi: 10.1007/s11783-017-0966-y
关键词: coal-fired chain-grate boiler PM10 size distribution particulate emission control devices size-dependent collection efficiency
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice
《医学前沿(英文)》 页码 957-971 doi: 10.1007/s11684-023-0988-8
关键词: DNAH10 mice motile cilia mutation primary ciliary dyskinesia
《医学前沿(英文)》 2022年 第16卷 第4期 页码 596-609 doi: 10.1007/s11684-021-0868-z
关键词: innate immune checkpoint Siglec10 kidney renal clear cell carcinoma
The most influential “Top 10 Events” in carbon neutrality and climate change in 2022
《能源前沿(英文)》 2023年 第17卷 第1期 页码 1-4 doi: 10.1007/s11708-023-0869-5
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
《医学前沿(英文)》 2008年 第2卷 第3期 页码 298-302 doi: 10.1007/s11684-008-0057-3
关键词: inflammatory presence interleukin-10 dose-dependent ox-LDL
Preface of special issue of the 10 th International Conference on CO 2 Utilization
Changjun LIU,
《化学科学与工程前沿(英文)》 2010年 第4卷 第2期 页码 109-109 doi: 10.1007/s11705-009-0258-6
《医学前沿(英文)》 2022年 第16卷 第6期 页码 969-974 doi: 10.1007/s11684-021-0912-z
关键词: severe malaria nigeria malaria mortality PfPR2-10 intermediate malaria transmission
《农业科学与工程前沿(英文)》 2022年 第9卷 第2期 页码 309-311 doi: 10.15302/J-FASE-2022440
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 24-32 doi: 10.1007/s11684-014-0312-8
In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.
关键词: osteopontin (OPN) hepatocellular carcinoma metastasis prognosis therapeutic target biomarker genetic polymorphism
NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation
Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li
《医学前沿(英文)》 2019年 第13卷 第6期 页码 646-657 doi: 10.1007/s11684-018-0643-y
关键词: androgen-independent prostate cancer normal epithelial cell-specific 1/kallikrein 10 sodium/iodide symporter radiation therapy proliferation
山奈酚作为新型ADAM10抑制剂治疗金黄色葡萄球菌感染 Article
王婷婷, 王建锋, 许湘竹, 蒋帆, 吕红发, 齐清辉, 张灿, 吕强华, 邓旭明
《工程(英文)》 2023年 第28卷 第9期 页码 206-221 doi: 10.1016/j.eng.2023.03.006
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 410-422 doi: 10.1007/s11684-017-0527-6
Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusion protein causes lethal hyperfibrinolysis in acute promyelocytic leukemia (APL), but the mechanism is unclear. To facilitate the investigation of regulatory association between ANXA2 and promyelocytic leukemia/retinoic acid receptor a (PML/RARα) fusion protein, this work was performed to determine the transcription start site of ANXA2 promoter with rapid amplification of 5′-cDNA ends analysis. Zinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2 transcripts and translational expressions of both ANXA2 and S100A10, while S100A10 transcripts remained constitutive. The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higher than that by control pSG5 vector or wild-type RARα. The overexpression of ANXA2 in U937 transfected with full-length ANXA2 cDNA was associated with increased S100A10 subunit, although S100A10 transcripts remained constitutive. The tPA-dependent initial rate of plasmin generation (IRPG) in zinc-treated U937/PR9 increased by 2.13-fold, and cell invasiveness increased by 27.6%. Antibodies against ANXA2, S100A10, or combination of both all remarkably inhibited the IRPG and invasiveness in U937/PR9 and NB4. Treatment of zinc-induced U937/PR9 or circulating APL blasts with all-trans retinoic acid (ATRA) significantly reduced cell surface ANXA2 and S100A10 and associated reductions in IRPG and invasiveness. Thus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate S100A10. Increased AIIt promoted IRPG and invasiveness, both of which were partly abolished by antibodies against ANXA2 and S100A10 or by ATRA.
关键词: annexin A2-S100A10 heterotetramer PML/RARα fusion protein plasmin cell invasion acute promyelocytic leukemia
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《医学前沿(英文)》 2012年 第6卷 第1期 页码 94-99 doi: 10.1007/s11684-012-0181-y
Systematic reviews and meta-analyses are playing an increasingly important role in clinical research and practice. This study aimed to measure the scientific production of systematic review and meta-analysis from the three major regions of China: the Mainland (ML), Hong Kong (HK), and Taiwan (TW). English articles on systematic review and meta-analysis from ML, HK, and TW from 2001 to 2010 were retrieved from the PubMed database. The total number of articles, impact factors (IF), and articles published in high-impact journals were conducted for quantity and quality comparisons among the three regions. There were 1 587 published articles from ML (1 292), HK (203), and TW (92) during the past ten years. The annual total numbers of articles in the three regions increased significantly from 2001 to 2010 (from 13 to 677). The number of articles from ML has exceeded that from TW since 2001, and surpassed that from HK in 2003. The accumulated IF of articles from ML (3 488.24) was higher than those from HK (493.16) and TW (216.39). HK had the highest average IF of 3.31, followed by ML of 2.90 and TW of 2.85. Researchers from HK published a larger proportion of papers in high-impact journals than those from ML and TW. The Cochrane Database of Systematic Reviews was the most popular journal in China. Chinese authors have been very active to enhance the systematic review and meta-analysis research over the past ten years, especially in ML. The gap between ML and the other two regions has been narrowed. But there is still considerable room for Chinese authors to improve their studies on systematic review and meta-analysis.
关键词: systematic review meta-analysis China Chinese impact factor
屠海令,孙棕檀,姚源,徐源
《中国工程科学》 2017年 第19卷 第5期 页码 85-91 doi: 10.15302/J-SSCAE-2017.05.015
《麻省理工科技评论》自2001年起每年发布“全球十大突破性技术”,关注技术的商业应用潜力及其对人类生活和社会的重大影响。本文从技术影响类型、技术领域等角度入手,对《麻省理工科技评论》近六年发布的60项突破性技术进行深入理解和分析,为准确把握未来产业动态和科技趋势提供借鉴。
关键词: 科技评论 “全球十大突破性技术” 商业 产业 社会
标题 作者 时间 类型 操作
Cohort study of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation of risk models and new predictor of pulmonary consolidation on computed tomography
Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu
期刊论文
Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient
期刊论文
Effect of IL-10 on formation of foam cell induced by ox-LDL
WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng
期刊论文
Preface of special issue of the 10 th International Conference on CO 2 Utilization
Changjun LIU,
期刊论文
Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in
期刊论文
GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021
期刊论文
Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies
null
期刊论文
NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation
Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li
期刊论文
Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent
null
期刊论文
Scientific publications on systematic review and meta-analysis from Chinese authors: a 10-year survey
null
期刊论文