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面向客户需求的产品优化设计方法研究

李汝鹏,魏巍,周峰,邹成

《中国工程科学》 2018年 第20卷 第2期   页码 33-41 doi: 10.15302/J-SSCAE-2018.02.006

摘要： 本文提出了一种快速响应客户需求的产品优化设计方法，通过基于模糊相似理论的需求信息模糊聚类方法，对具有模糊性和多样性的原始客户需求信息进行精简分类处理，以获取客户需求集合；然后构建了一种综合联合分析法（CA）和质量功能展开（QFD）的全新CA-QFD需求转化方法，从客户需求到产品设计属性进行精确转化，并通过对实例产品的优化设计，实现快速响应客户需求；最后，通过锻压机主工作液压缸的优化设计实例，验证了本文方法的可行性和适用性

关键词： 快速响应客户需求     模糊聚类     需求转化     CA-QFD方法     产品优化设计    

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NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

《医学前沿（英文）》 2023年 第17卷 第2期   页码 263-274 doi: 10.1007/s11684-022-0935-0

摘要： Melanoma is the most aggressive cutaneous tumor. Neuropilin and tolloid-like 2 (NETO2) is closely related to tumorigenesis. However, the functional significance of NETO2 in melanoma progression remains unclear. Herein, we found that NETO2 expression was augmented in melanoma clinical tissues and associated with poor prognosis in melanoma patients. Disrupting NETO2 expression markedly inhibited melanoma proliferation, malignant growth, migration, and invasion by downregulating the levels of calcium ions (Ca2+) and the expression of key genes involved in the calcium signaling pathway. By contrast, NETO2 overexpression had the opposite effects. Importantly, pharmacological inhibition of CaMKII/CREB activity with the CaMKII inhibitor KN93 suppressed NETO2-induced proliferation and melanoma metastasis. Overall, this study uncovered the crucial role of NETO2-mediated regulation in melanoma progression, indicating that targeting NETO2 may effectively improve melanoma treatment.

关键词： melanoma     neuropilin and tolloid-like 2     Ca2+/CaMKII signaling pathway    

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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca

《医学前沿（英文）》 doi: 10.1007/s11684-023-0983-0

摘要： Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis in a murine model of HFpEF

关键词： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Effect of K and Ca on catalytic activity of Mn-CeO

Boxiong SHEN, Lidan DENG, Jianhong CHEN

《环境科学与工程前沿（英文）》 2013年 第7卷 第4期   页码 512-517 doi: 10.1007/s11783-013-0519-y

摘要： Mn-CeO /Ti-pillared clay (PILC) is an attractive catalyst for selective catalytic reduction of NO at low temperature because of its low cost. The poisoning of K and Ca on the catalyst of Mn-CeO /Ti-PILC is an important problem because K and Ca are always in presence in flue gas. To investigate the effect of K and Ca on the physicochemical characters of the catalysts, the techniques of NH -temperature programmed desorption (TPD), H -temperature programmed reduction (TPR), and X-ray photoelectron spectroscopy (XPS) were used to analyze the fresh and deactivated catalysts of Mn-CeO /Ti-PILC. (Ca)Mn-CeO /Ti-PILC and (K)Mn-CeO /Ti-PILC are denoted for the dopes of the catalyst of Mn-CeO /Ti-PILC with Ca and K, respectively. The activities of Mn-CeO /Ti-PILC, (Ca)Mn-CeO /Ti-PILC and (K)Mn-CeO /Ti-PILC for NH -selective catalytic reduction (SCR) reaction at low temperature were investigated. The results showed that with the dopes of K and Ca on the catalysts, the SCR activities of the catalysts decreased greatly, and K exhibited more poisoning effect than Ca. With the dopes of K and Ca, the acidity, the redox property and chemisorbed oxygen on the surfaces of the catalysts were decreased, which resulted in a decreasing in SCR activity.

关键词： Mn-CeOx/Ti-pillared clay (PILC)     low-temperature selective catalytic reduction (SCR)     K and Ca poisoning effect    

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Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

《医学前沿（英文）》 2007年 第1卷 第4期   页码 418-422 doi: 10.1007/s11684-007-0082-7

摘要： The effects of heat stress on the neurons in hippocampal CA1 region of brain ischemia/reperfusion were explored. The mice were pretreated with heat stress followed by ischemia/reperfusion by clipping bilateral cervical commo n arteries for 7 min. Mice were divided randomly into four groups as follows: (1) normal control group; (2) heat stress pretreated subsequent to ischemia/reperfusion group (HS/IR); (3) ischemia/reperfusion group (IR); and (4) heat stress group (HS). Animals in the last three groups were subdivided into three subgroups: 1 d, 4 d, 14 d respectively. The Morris water maze was used to test the ability of learning and memorizing, Nissl staining was used to count the average number of survived neurons in hippocampal CA1 region, and immunohistochemistry combined with image analysis system to detect the changes of Microtubule associated protein 2 (MAP-2) expression. The results showed that mice in IR group exhibited increased escape latency when compared with that of normal, HS and HS/IR groups (<0.01), and the mice in IR group adopted an inefficient search strategy, major in circling and restricted searching manners. Nissl staining results showed a significant reduction in the number of pyramidal neurons in hippocampal CA1 regions in HS/IR and IR groups, with a decrease in IR group (<0.01). Compared with normal group, the expression of MAP-2 in hippocampal CA1 region obviously decreased in IR group (<0.05). The present results indicate that heat stress pretreatment can improve the spatial learning and memorizing function through protection to hippocampal neurons.
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Laboratory study on high-temperature adsorption of HCl by dry-injection of Ca(OH)

Junjun TAN,Guohua YANG,Jingqiao MAO,Huichao DAI

《环境科学与工程前沿（英文）》 2014年 第8卷 第6期   页码 863-870 doi: 10.1007/s11783-013-0618-9

摘要： Combustion-generated hydrogen chloride (HCl) is considered to be a very hazardous acid gaseous pollutant. This paper presents a laboratory study on the dry adsorption of HCl. The experiments were conducted in a dual-layer granular bed filter, at gas temperatures of 500°C–700°C and (Ca)/ (Cl)molar ratios of 1.0–5.0 using the silver nitrate titration method by dry adsorbent powders Ca(OH) . Mainly, the adsorption efficiency of HCl and utilization efficiency of Calcium were studied, by varying relevant factors including (Ca)/ (Cl), temperature, feeding method, water vapor and CO . With a relatively higher HCl concentration of 1000 ppm, the experimental results revealed that 600°C may be the optimum temperature for HCl adsorption when optimum (Ca)/ (Cl) was 2.5 in our tests. The results also demonstrated that the feeding at a constant pressure was more effective, and the HCl adsorption efficiency could rapidly reach over 90% with (Ca)/ (Cl) = 2.5 at 600°C. Furthermore, the HCl adsorption efficiency was found to be slightly promoted by water vapor, while could be impeded by CO , and the utilization efficiency of calcium could be up to 74.4% without CO , while was only 36.8% with CO when (Ca)/ (Cl) was 2.5 at 600°C.

关键词： acid gas HCl     Ca(OH)2     dry adsorption     high temperature     dual-layer granular bed filter    

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虚实融合的协同工作环境CAR-CA工程技术研究进展

赵沁平

《中国工程科学》 2009年 第11卷 第10期   页码 25-31

摘要： 面向我国自行设计生产商用大飞机的需求，在863计划支持下，正在研制用于驾驶舱布局设计和飞机关键部件辅助拆装维护的虚 实融合协同工作环境CAR-CA（collaborative augmented reality概要介绍CAR-CA的工程技术研究进展，包括体系结构、系统组成、关键技术研究和系统的应用前景等。

关键词： 虚实融合     协同工作     驾驶舱     设计     维护    

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Augmented hydrogen production by gasification of ball milled polyethylene with Ca(OH)

Giovanni Cagnetta, Kunlun Zhang, Qiwu Zhang, Jun Huang, Gang Yu

《环境科学与工程前沿（英文）》 2019年 第13卷 第1期 doi: 10.1007/s11783-019-1096-5

摘要：

PE ball milling pretreatment induces higher H2 production and purity by gasification.

Ca(OH)2 reacts at solid state with PE boosting H2 and capturing CO2.

Ca(OH)2 significantly reduces methanation side-reaction.

关键词： Hydrogen production     Gasification     Plastic waste     High energy ball milling    

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Kinetics of pozzolanic reaction for preparation of flue gas desulfurizer from fly ash and Ca(OH)2

WANG Jingang, HU Jinbang, WANG Daobin, DUAN Zhenya

《化学科学与工程前沿（英文）》 2007年 第1卷 第3期   页码 266-270 doi: 10.1007/s11705-007-0048-y

摘要： A kinetic model of the pozzolanic reaction for the preparation of flue gas desulfurizers from fly ash and Ca(OH) was deduced on the basis of solid phase reaction kinetic theory. Kinetic expressions and parameters were obtained and verified by experiment. A comparison of calculated results with experimental results showed that precision in kinetic expressions was good. The apparent reaction rate constants of the pozzolanic reaction could be raised by increasing the specific surface area of fly ash and the hydration temperature, and by using a suitable additive.

关键词： comparison     calculated     pozzolanic reaction     precision     preparation    

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具有泵送控释性能的肠靶向Janus型双腔室海藻酸钙基微胶囊 Article

温霜, 巨晓洁, 刘文英, 刘玉琼, 蒲兴群, 刘壮, 汪伟, 谢锐, Yousef Faraj, 褚良银

《工程（英文）》 2023年 第24卷 第5期   页码 114-125 doi: 10.1016/j.eng.2022.05.021

摘要：

本文成功开发了一种具有泵送控释特性的θ形双腔室肠靶向海藻酸钙基微胶囊，囊壁为海藻酸钙-壳聚糖/精蛋白/二氧化硅（ACPSi）复合壳，为封装的药物在胃环境中提供了良好保护，实现药物的肠靶向释放。该θ形微胶囊由含药室和助推室两个腔室组成：含药室负载疏水药物吲哚美辛，其囊壁内嵌肠溶性
羟丙甲基纤维素邻苯二甲酸酯（HPMCP）微球，作为“微阀门”（micro-valves）；助推室包封助推剂聚丙烯酸（PAA），在肠液环境中，PAA发生溶胀，可提高吲哚美辛释放速率。结果显示，载药的θ-ACPSi 微胶囊在模拟胃液（pH值为2.5）中，吲哚美辛的释放率小于1%。然而，进入模拟肠液（pH值为6.8）时，含药室囊壁中的HPMCP微球溶解，释药“微通道”（microchannel）被打开，同时助推室中的PAA发生溶胀，为药物的释放提供推动力。结果，吲哚美辛在小肠中以恒定的速度释放60%以上。因此，该θ-ACPSi 微胶囊具有良好的泵送和肠靶向控释性能，为口服肠道靶向给药系统的开发提供了一种新策略。

关键词： 微胶囊     海藻酸钙     肠靶向递送     泵送性能     控制释放    

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Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: A meta-analysis

Shang-Long LIU, Zi-Fang SONG, Qing-Gang HU, Shao-Bo HU, Jun LI, Qi-Chang ZHENG, Duo SHAN,

《医学前沿（英文）》 2010年 第4卷 第4期   页码 457-462 doi: 10.1007/s11684-010-0240-1

摘要： This study was performed to determine the prognostic role of preoperative serum carbohydrate antigen (CA) 19-9 levels in the survival of patients with cholangiocarcinoma. Articles published up to June 1, 2010 that evaluated preoperative CA19-9 levels and the prognosis of cholangiocarcinoma were collected for meta-analysis. The required information for calculating individual relative risk (RR) was extracted from the studies, and a combined overall RR was estimated. Nine eligible studies were included. One study dealt with extra-hepatic cholangiocarcinoma, while the other eight studies analyzed intra-hepatic cholangiocarcinoma. The mean methodological quality score was 74.1%, ranging from 65.5% to 82.5%. The overall RR for the nine studies was 1.28 (95% confidence interval= 1.10–1.46), and the Z-score for overall effect was 13.83 (<0.001). The association between serum CA19-9 level and lymph node involvement was also assessed. The combined RR was 1.471 (95% confidence interval= 0.411–5.264) and Z-score for overall effect was 0.59 ( = 0.553). CA19-9 levels were associated significantly with the prognosis of patients with cholangiocarcinoma. This meta-analysis shows that elevation of preoperative CA19-9 levels is correlated with a poor prognosis of patients with cholangiocarcinoma. However, larger scale and randomized studies are needed to draw a more substantive conclusion.

关键词： cholangiocarcinoma     prognostic factors     serum carbohydrate antigen 19-9    

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Numerical study of EGR effects on reducing the pressure rise rate of HCCI engine combustion

Gen CHEN, Norimasa IIDA, Zuohua HUANG,

《能源前沿（英文）》 2010年 第4卷 第3期   页码 376-385 doi: 10.1007/s11708-010-0118-6

摘要： The effects of the inert components of exhaust gas recirculation (EGR) gas on reducing the pressure rise rate of homogeneous charge compression ignition engine combustion were investigated numerically by utilizing the CHEMKIN II package and its SENKIN code, as well as Curran’s dimethyl ether reaction scheme. Calculations were conducted under constant volume combustion and engine combustion (one compression and one expansion only, respectively) conditions. Results show that with constant fuel amount and initial temperature and pressure, as EGR ratio increases, combustion timings are retarded and the duration of thermal ignition preparation extends non-linearly; peak values of pressure, pressure rising rate (PRR), and temperature decrease; and peak values of heat release rate in both low temperature heat release (LTHR) and high temperature heat release decrease. Moreover, maximum PRR decreases as CA50 is retarded. With constant fuel amount, mixtures with different EGR ratios can obtain the same CA50 by adjusting the initial temperature. Under the same CA50, as EGR ratio increases, the LTHR timing is advanced and the duration of thermal ignition preparation is extended. Maximum PRR is almost constant with the fixed CA50 despite the change in EGR ratio, indicating that the influence of EGR dilution on chemical reaction rate is offset by other factors. Further investigation on the mechanism of this phenomenon is needed.

关键词： HCCI engine     combustion     EGR     DME     CA50     PRR    

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Optimization of Land-use Based on the Theory of Cellular Automata and Value of Ecosystem Services

Lian-fu Jiang,Guo-xian Xu,Hao Jiang

《工程管理前沿（英文）》 2014年 第1卷 第4期   页码 395-401 doi: 10.15302/J-FEM-2014058

摘要： The main objective of the study was to confirm the location and configuration of “Habitat Conservation Area” in Dongguan City. The land utilization condition in the target city was simulated using Arc GIS and Geo SOS software basing on multi-criteria decision model of Cellular Automata (CA). Both the simulation result and accuracy satisfied well the basic requirements. In addition to multi-criteria decision model, space optimization technique was used as well in simulation experiments.

关键词： Ecosystem service function     optimization of land use     Cellular Automata (CA)    

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Formation of CaCO hollow microspheres in carbonated distiller waste from Solvay soda ash plants

《化学科学与工程前沿（英文）》   页码 1659-1671 doi: 10.1007/s11705-022-2173-z

摘要： For decades, distiller waste and CO2 were not the first choice for production of high valued products. Here, CaCO3 hollow microspheres, a high-value product was synthesized from such a reaction system. The synthetic methods, the formation mechanism and operational cost were discussed. When 2.5 L·min–1·L–1 CO2 was flowed into distiller waste (pH = 11.4), spheres with 4–13 μm diameters and about 2 μm shell thickness were obtained. It is found that there is a transformation of CaCO3 particles from solid-cubic nuclei to hollow spheres. Firstly, the Ca(OH)2 in the distiller waste stimulated the nucleation of calcite with a non-template effect and further maintained the calcite form and prevented the formation of vaterite. Therefore, in absence of auxiliaries, the formation of hollow structures mainly depended on the growth and aging of CaCO3. Studies on the crystal morphology and its changes during the growth process point to the inside–out Ostwald effect in the formation of hollow spheres. Change in chemical properties of the bulk solution caused changes in interfacial tension and interfacial energy, which promoted the morphological transformation of CaCO3 particles from cubic calcite to spherical clusters. Finally, the flow process for absorption of CO2 by distiller waste was designed and found profitable.

关键词： distiller waste     CO2     hollow microsphere     CaCO3     Ca(OH)2     inside−out Ostwald effect    

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Pore-scale simulation of water/oil displacement in a water-wet channel

Jin Zhao, Guice Yao, Dongsheng Wen

《化学科学与工程前沿（英文）》 2019年 第13卷 第4期   页码 803-814 doi: 10.1007/s11705-019-1835-y

摘要： Water/oil flow characteristics in a water-wet capillary were simulated at the pore scale to increase our understanding on immiscible flow and enhanced oil recovery. Volume of fluid method was used to capture the interface between oil and water and a pore-throat connecting structure was established to investigate the effects of viscosity, interfacial tension (IFT) and capillary number ( ). The results show that during a water displacement process, an initial continuous oil phase can be snapped off in the water-wet pore due to the capillary effect. By altering the viscosity of the displacing fluid and the IFT between the wetting and non-wetting phases, the snapped-off phenomenon can be eliminated or reduced during the displacement. A stable displacement can be obtained under high number conditions. Different displacement effects can be obtained at the same number due to its significant influence on the flow state, i.e., snapped-off flow, transient flow and stable flow, and ultralow IFT alone would not ensure a very high recovery rate due to the fingering flow occurrence. A flow chart relating flow states and the corresponding oil recovery factor is established.

关键词： VOF     pore scale     immiscible displacement     EOR     snap-off     Ca    

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标题 作者 时间 类型 操作

面向客户需求的产品优化设计方法研究

李汝鹏,魏巍,周峰,邹成

期刊论文

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

期刊论文

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca

期刊论文

Effect of K and Ca on catalytic activity of Mn-CeO

Boxiong SHEN, Lidan DENG, Jianhong CHEN

期刊论文

Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

期刊论文

Laboratory study on high-temperature adsorption of HCl by dry-injection of Ca(OH)

Junjun TAN,Guohua YANG,Jingqiao MAO,Huichao DAI

期刊论文

虚实融合的协同工作环境CAR-CA工程技术研究进展

赵沁平

期刊论文

Augmented hydrogen production by gasification of ball milled polyethylene with Ca(OH)

Giovanni Cagnetta, Kunlun Zhang, Qiwu Zhang, Jun Huang, Gang Yu

期刊论文

Kinetics of pozzolanic reaction for preparation of flue gas desulfurizer from fly ash and Ca(OH)2

WANG Jingang, HU Jinbang, WANG Daobin, DUAN Zhenya

期刊论文

具有泵送控释性能的肠靶向Janus型双腔室海藻酸钙基微胶囊

温霜, 巨晓洁, 刘文英, 刘玉琼, 蒲兴群, 刘壮, 汪伟, 谢锐, Yousef Faraj, 褚良银

期刊论文

Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: A meta-analysis

Shang-Long LIU, Zi-Fang SONG, Qing-Gang HU, Shao-Bo HU, Jun LI, Qi-Chang ZHENG, Duo SHAN,

期刊论文

Numerical study of EGR effects on reducing the pressure rise rate of HCCI engine combustion

Gen CHEN, Norimasa IIDA, Zuohua HUANG,

期刊论文

Optimization of Land-use Based on the Theory of Cellular Automata and Value of Ecosystem Services

Lian-fu Jiang,Guo-xian Xu,Hao Jiang

期刊论文

Formation of CaCO hollow microspheres in carbonated distiller waste from Solvay soda ash plants

期刊论文

Pore-scale simulation of water/oil displacement in a water-wet channel

Jin Zhao, Guice Yao, Dongsheng Wen

期刊论文