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The FGF metabolic axis

Xiaokun Li

《医学前沿（英文）》 2019年第13卷第5期页码 511-530 doi: 10.1007/s11684-019-0711-y

摘要： Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members by acquiring divergent structural elements that enable functional divergence and specification. Heparan sulfate-binding FGFs, which play critical roles in embryonic development and adult tissue remodeling homeostasis, adapt to an autocrine/paracrine mode of action to promote cell proliferation and population growth. By contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparan sulfate while acquiring affinity for transmembrane α-Klotho (KL) or β-KL as a coreceptor, thereby adapting to an endocrine mode of action to drive interorgan crosstalk that regulates a broad spectrum of metabolic homeostasis. FGF19 metabolic axis from the ileum to liver negatively controls diurnal bile acid biosynthesis. FGF21 metabolic axes play multifaceted roles in controlling the homeostasis of lipid, glucose, and energy metabolism. FGF23 axes from the bone to kidney and parathyroid regulate metabolic homeostasis of phosphate, calcium, vitamin D, and parathyroid hormone that are important for bone health and systemic mineral balance. The significant divergence in structural elements and multiple functional specifications of FGF19, 21, and 23 in cellular and organismal metabolism instead of cell proliferation and growth sufficiently necessitate a new unified and specific term for these three endocrine FGFs. Thus, the term “FGF Metabolic Axis,” which distinguishes the unique pathways and functions of endocrine FGFs from other autocrine/paracrine mitogenic FGFs, is coined.

关键词： FGF19 FGF21 FGF23 FGFR metabolism endocrine Klotho

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

《医学前沿（英文）》 2013年第7卷第1期页码 25-30 doi: 10.1007/s11684-013-0244-8

摘要：

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.

关键词： FGF21 metabolism pharmacology physiology clinical relevance

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FGF23 associated bone diseases

null

《医学前沿（英文）》 2013年第7卷第1期页码 65-80 doi: 10.1007/s11684-013-0254-6

摘要：

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease.

关键词： fibroblast growth factor 23 FGF receptor phosphate metabolism Klotho bone disease

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

《医学前沿（英文）》 2022年第16卷第6期页码 896-908 doi: 10.1007/s11684-022-0944-z

摘要： Fibroblast growth factor 13 (FGF13) is aberrantly expressed in multiple cancer types, suggesting its essential role in tumorigenesis. Hence, we aimed to explore its definite role in the development of acute myeloid leukemia (AML) and emphasize its associations with bone marrow niches. Results showed that FGF13 was lowly expressed in patients with AML and that its elevated expression was related to prolonged overall survival (OS). Univariate and multivariate Cox regression analyses identified FGF13 as an independent prognostic factor. A prognostic nomogram integrating FGF13 and clinicopathologic variables was constructed to predict 1-, 3-, and 5-year OS. Gene mutation and functional analyses indicated that FGF13 was not associated with AML driver mutations but was related to bone marrow niches. As for immunity, FGF13 was remarkably associated with T cell count, immune checkpoint genes, and cytokines. In addition, FGF13 overexpression substantially inhibited the growth and significantly induced the early apoptosis of AML cells. The xenograft study indicated that FGF13 overexpression prolonged the survival of recipient mice. Overall, FGF13 could serve as an independent prognostic factor for AML, and it was closely related to the bone marrow microenvironment.

关键词： acute myeloid leukemia FGF13 prognosis immune-related genes bone marrow niches

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

《医学前沿（英文）》 2009年第3卷第1期页码 61-66 doi: 10.1007/s11684-009-0007-8

摘要： The aim of this study was to explore the regulatory mechanism of retinoic acid (RA) on the TBX1 gene expression in myocardial cells. Ventricular cardiocytes were isolated from neonatal rats and cultured, and then treated with different concentrations of retinoic acid. The expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measured by using RT-PCR and Western blot technique, respectively. There was basal expression of Shh and Fgf8 in the control group. When treated with 3×10 mol/L RA, we observed that the expression of Shh mRNA and protein in neonatal rat myocardial cells were up-regulated by 1.51 ( <0.05) and 1.10 times ( <0.05), respectively. In comparison with the control group, under the concentration of 5×10 mol/L RA, they were up-regulated by 2.21 ( <0.05) and 2.38 times ( <0.05) individually. Meanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 times ( <0.05) and 80% ( <0.05) separately compared with the control group after stimulation of 3×10 mol/L RA, and they were up-regulated by 3.48 ( <0.05) and 2.04 times ( <0.05) individually after stimulation of 5×10 mol/L RA. The results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardial cells. At the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1 expression.

关键词： retinoic acid Tbx1 protein Shh protein Fgf8 protein

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面向21世纪的中国林业遥感

赵宪文

《中国工程科学》 1999年第1卷第3期页码 16-21

摘要：对21世纪中国林业遥感前景进行了展望。作者认为下一个世纪中国林业遥感发展的主要方向是：包容各种新技术，形成新的技术体系，并与国际接轨；利用遥感的优势，研究森林的宏观状况与作用；与森林经营进一步结合。

关键词：林业遥感持续发展 21世纪

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21世纪油气工业发展刍议

陈俊武

《中国工程科学》 2000年第2卷第4期页码 21-24

摘要：文章从世界能源消费不断增长的社会发展需求出发，考虑日益苛刻的环境保护政策和举世关心的可持续发展的战略方针，结合今后科学技术的进展，分别从产品需求和资源供应、产品规格和环境保护、非常规石油进入角色及天然气前景引人瞩目四个专题进行论述，对21

关键词： 21世纪石油天然气油气工业

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21世纪人类生活与生存的科技

蒋正华

《中国工程科学》 2002年第4卷第4期页码 1-11

摘要：

从管理学角度回顾了过去百年的世界历史，研究新世纪可能发生的进步，并探讨更好地建立世界和平与合作，实现共同发展的方案。

关键词： 21世纪科技进步人类生活与生存

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Digital manufacturing—the development direction of the manufacturing technology in the 21st century

XIONG You-lun, YIN Zhou-ping

《机械工程前沿（英文）》 2006年第1卷第2期页码 125-130 doi: 10.1007/s11465-006-0021-3

摘要： After introducing the concepts of digital manufacturing technology, the discipline framework of digital manufacturing is presented in the paper by discussing its basic concept, theory foundation, key technology and scientific problems in detail. As the core of the advanced manufacturing technology, digital manufacturing is gradually becoming the main manufacturing technology of the twenty-first century. Firstly, the main features of digital manufacturing are indicated and its key supporting technologies are investigated by grouping them into four levels related to product development, numerical control, production management, and enterprise collaboration, respectively. Moreover, the existing problems in the research on the multi-discipline theory foundation of digital manufacturing such as manufacturing informatics, computational manufacturing, and manufacturing intelligence, are also indicated. Then, the core scientific problems of digital manufacturing are discussed in depth, which focuses on digitization of manufacturing information, modeling of manufacturing constraints, high-speed and high-precision numerical control theory, and Internet-based collaboration and integration. Lastly, the development trends and application perspectives of digital manufacturing are concluded.

关键词： development foundation multi-discipline scientific supporting

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21世纪计算与信息技术的挑战

Wm. A. Wulf

《中国工程科学》 2000年第2卷第10期页码 9-12

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新材料发展现状及21世纪发展趋势研讨会

《中国工程科学》 2001年第3卷第11期页码 88-94

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How diplomacy saved the COP21 Paris Climate Conference, but now, can we save ourselves?

D. Nathaniel MULCAHY, David L. MULCAHY

《能源前沿（英文）》 2018年第12卷第3期页码 344-352 doi: 10.1007/s11708-017-0498-y

摘要：

To solve a problem, three things are necessary: awareness, means, and will. The 2015 COP21 Paris accord was a masterful, perhaps even world-saving, diplomatic advance toward making the world aware of climate change. Some of that success may have been because publications from the IPCC and the National Academy of Science were made available, on line, as prepublication offerings, in order to be widely viewed before the Paris Climate Conference. This provided diplomats and negotiators with the latest information about climate change, its nearness in time, its consequences, and how well current mitigation technologies can succeed. Whatever the reasons, the Paris Climate Conference, was a success. Leaders of 195 nations agreed that climate change is a real and present danger to life as is known to all. This important understanding was accomplished despite the presentation of well established scientific facts which, without very diplomatic handling, could easily have evoked overwhelming political opposition to an agreement and thus another COP failure. In this paper, the fact that how some scientific truths, written specifically to be overlooked, were presented in order to prepare COP21 participants for the conference is explained. Besides, the effectiveness and efficiency of currently favored mitigation policies, the extent of ongoing progress to better ones, and finally, how a new appreciation of climate change consequences can strengthen the will of nation states and industries to work toward solutions are evaluated.

关键词： COP21 Paris climate agreement offsets mitigation IPCC

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新材料发展现状及21世纪发展趋势研讨会论文摘要

《中国工程科学》 2001年第3卷第12期页码 100-101

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Silk Roads for the 21st Century: Engineering Mega-Infrastructure for Development and Sustainability

Tony Marjoram

《工程管理前沿（英文）》 2016年第3卷第3期页码 187-196 doi: 10.15302/J-FEM-2016038

摘要： Infrastructure facilitates the movement of people, the production and distribution of goods and services, and underpins development. Infrastructure is expensive and long-lasting, and needs long-term policy, planning and management, in terms of design, construction, operation and maintenance. Infrastructure relates particularly to engineering and technology. All technological change brings economic, social, cultural and environmental change, planned and unpredicted. Mega levels of technology bring mega levels of change, effects and impacts. Mega infrastructure such as the Silk Road Economic Belt and 21st Century Maritime Silk Road, the “One Belt, One Road” (OBOR) initiative, announced by President Xi Jinping in 2013, will require equally mega policy, planning and management. This paper will discuss policy, planning and management issues relating to mega infrastructure and the OBOR initiative, with particular reference to energy, communications, transportation, health, emergency preparedness and response, and less predictable areas of change, for example in disease prevention and control, within the overall need for economic, environmental and ecological sustainability. The paper will discuss associated needs for education, training and capacity building in engineering. The paper will also refer to lessons learnt from the original Silk Road in the context of the development of civilizations and intercultural dialogue through the transfer of goods, services, technologies, ideas, knowledge, customs, cultures and philosophies, less predictable and unwanted transfers, for example of disease, and the need for awareness, policy, planning and management of such wider issues.

关键词： infrastructure growth development sustainability change new Silk Roads