检索范围:
排序: 展示方式:
《医学前沿(英文)》 2022年 第16卷 第4期 页码 551-573 doi: 10.1007/s11684-022-0928-z
关键词: HCC bone osteotropism clinical basic researches advances
The impact of hypoxia in hepatocellular carcinoma metastasis
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 33-41 doi: 10.1007/s11684-013-0301-3
Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC). Hypoxia stabilizes transcription factor, hypoxia-inducible factor (HIF), to activate gene transcription. Expression of HIF is closely associated with metastasis and poor prognosis in HCC. HIF mediates expression of genes that are involved in every step of HCC metastasis including epithelial-mesenchymal transition, invasion of the extracellular matrix, intravasation, extravasation, and secondar y growth of the metastases. Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when used alone or as combined treatment to curb HCC metastasis. This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular focus on cancer metastasis.
关键词: hypoxia hepatocellular carcinoma (HCC) metastasis hypoxia-inducible factor (HIF)
肠道菌群调节在肝细胞癌和肝移植中的应用 Review
向泽, 吴健, 李佳芮, 郑树森, 魏绪勇, 徐骁
《工程(英文)》 2023年 第29卷 第10期 页码 59-72 doi: 10.1016/j.eng.2022.12.012
肝细胞癌(HCC)是最常见的肝脏恶性肿瘤,严重危害公众健康。肝移植(LT)是治疗HCC的有效方法,但缺血再灌注(I/R)损伤、移植排斥反应及各类并发症会大大降低其疗效。肠道菌群通过微生物群-肠道-肝脏轴对HCC的发生、发展以及LT疗效产生影响。本文综述了肠道菌群与慢性肝病的双向相互作用及其影响HCC的机制,并且概括了肠道菌群在HCC中的诊断和预后价值。在移植肿瘤学时代,肠道菌群在HCC和LT中的作用应得到重视,这可以为临床瓶颈难题的解决提供新的见解。
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 90-95 doi: 10.1007/s11684-010-0021-x
关键词: cyclooxygenase-2 gene single nucleotide polymorphisms susceptibility primary hepatocellular carcinoma hepatitis B virus infection
Jianpeng Liu, Xinhua Chen, Shusen Zheng
《医学前沿(英文)》 2021年 第15卷 第2期 页码 170-177 doi: 10.1007/s11684-020-0747-z
关键词: nanosecond pulsed electric fields (nsPEF) hepatocellular carcinoma (HCC) immune response recurrence metastasis
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 322-330 doi: 10.1007/s11684-015-0408-9
This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma (HCC) by comparing the global gene expression profiles between tumors and their corresponding non-tumorous liver tissue. Based on the differential gene expression analysis, we identified a number of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated (CENPF and FOXM1) and downregulated (CLEC4G, CRHBP, and CLEC1B) genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview by subjecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new biomarkers and further in-depth characterization.
Towards the optimization of management of hepatocellular carcinoma
Xi Feng, Madhava Pai, Malkhaz Mizandari, Tinatin Chikovani, Duncan Spalding, Long Jiao, Nagy Habib
《医学前沿(英文)》 2011年 第5卷 第3期 页码 271-276 doi: 10.1007/s11684-011-0148-4
关键词: management hepatocellular carcinoma (HCC) radiofrequency (RF) ablation laparoscopic liver resection stem cell intravascular RF ablation endobiliary RF ablation
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 217-226 doi: 10.1007/s11684-014-0326-2
This study was designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the risk of hepatocellular carcinoma (HCC). A total of 1021 healthy controls, 302 HBV surface antigen (HBsAg) seroclearance subjects, and 2011 HBsAg-positive subjects (including 1021 HCC patients) were enrolled in this study. Quantitative PCR was used to genotype rs3783553. HBV mutations were determined by direct sequencing. Multivariate logistic regression analyses were performed to test the associations of rs3783553, mutations, and their interactions with the risk of HCC. No significant association was found between rs3783553 and the risk of HCC among healthy controls, HBsAg seroclearance subjects, HBsAg-positive subjects without HCC, and all controls. Additionally, rs3783553 was not significantly associated with chronic HBV infection, liver cirrhosis, HBV e antigen seroconversion, abnormal alanine aminotransferase, and high viral load (>104 copies/ml). However, the TTCA insertion allele of rs3783553 was significantly associated with an increased frequency of HBV C7A mutation compared with homozygous TTCA deletion carriers [(del/ins+ ins/ins) vs. del/del, adjusted odds ratio (OR)=1.48, 95% confidence interval (CI)=1.09-2.02, P=0.013]. Multiplicative interaction of rs3783553 with HBV preS deletion significantly reduced the risk of HCC in males, with an adjusted OR of 0.64 (95% CI=0.42-0.98; P=0.041) after age and HBV genotype were adjusted. Although rs3783553 did not significantly affect genetic susceptibility to HBV-related HCC, its variant allele may predispose the host to selecting HBV C7A mutation during evolution and significantly reduce the risk of HCC caused by HBV preS deletion. This study provides an insight into the complex host-virus interaction in HBV-induced hepatocarcinogenesis and is helpful in determining HBsAg-positive subjects who are likely to develop HCC.
关键词: hepatocellular carcinoma (HCC) interaction miRNA-122-binding site IL-1A rs3783553 hepatitis B virus (HBV) mutations
Weiqi Rong, Yang Zhang, Lei Yang, Lin Feng, Baojun Wei, Fan Wu, Liming Wang, Yanning Gao, Shujun Cheng, Jianxiong Wu, Ting Xiao
《医学前沿(英文)》 2019年 第13卷 第2期 页码 250-258 doi: 10.1007/s11684-018-0632-1
标题 作者 时间 类型 操作
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives
期刊论文
Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
期刊论文
Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric field
Jianpeng Liu, Xinhua Chen, Shusen Zheng
期刊论文
TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma
null
期刊论文
Towards the optimization of management of hepatocellular carcinoma
Xi Feng, Madhava Pai, Malkhaz Mizandari, Tinatin Chikovani, Duncan Spalding, Long Jiao, Nagy Habib
期刊论文
Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk
null
期刊论文