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Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin
《医学前沿（英文）》 2018年 第12卷 第5期 页码 518-524 doi: 10.1007/s11684-017-0575-y
The increased levels of intracellular reactive oxygen species (ROS) in granulosa cells (GCs) may affect the pregnancy results in women with polycystic ovary syndrome (PCOS). In this study, we compared thein vitro fertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factor infertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group had significantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factor group (P<0.05); however, the number of retrieved oocytes was not significantly different between the two groups (P>0.05). PCOS group had slightly lower fertilization, cleavage, grade I/II embryo, clinical pregnancy, and implantation rates and higher miscarriage rate than the tubal factor group (P>0.05). We further found a significantly higher ROS level of GCs in the PCOS group than in the tubal factor group (P<0.05). The increased ROS levels in GCs caused GC apoptosis, whereas NADPH oxidase 2 (NOX2) specific inhibitors (diphenyleneiodonium and apocynin) significantly reduced the ROS production in the PCOS group. In conclusion, the increased ROS expression levels in PCOS GCs greatly induced cell apoptosis, which further affected the oocyte quality and reduced the positive IVF-ET pregnancy results of women with PCOS. NADPH oxidase pathway may be involved in the mechanism of ROS production in GCs of women with PCOS.
周丹妮,杨菁,吴庚香,李赛姣,余楠,赵萌,文妍琪
《中国工程科学》 2014年 第16卷 第5期 页码 79-84
探究体外受精—胚胎移植/单精子卵泡浆内注射-胚胎移植（IVF/ICSI）患者注射人绒毛膜促性腺激素（HCG）日血清雌孕激素水平对妊娠结局的影响回顾分析武汉大学人民医院生殖医学中心2011 年9 月—2012 年9 月符合相关条件行IVF的新鲜周期患者1 270 例，按血清孕酮值将其分为两组进行比较，低孕酮组HCG日血清孕酮值<
关键词： 孕酮值 HCG日 IVF/ICSI 新鲜周期 临床妊娠率
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《医学前沿（英文）》 2017年 第11卷 第4期 页码 563-569 doi: 10.1007/s11684-017-0535-6
The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer in infertile couples has been debated. This retrospective study included data collected from 1051 patients from July 2011 to June 2014. Multiple maternal baseline covariates were subjected to propensity score matching analysis, and each day 5/6 group woman was matched to one day 2/3 group woman. A systematic meta-analysis was conducted to validate the results. After matching was completed, 217 patients on the day 2/3 group were matched with those on the day 5/6 group, and no significant differences in the baseline characteristics were observed between the two groups. The cumulative pregnancy rate (57.14% vs. 53.46%, OR 1.16, 95% CI 0.79–1.70) and cumulative live birth rate (53.00% vs. 49.77%, OR 1.14, 95% CI 0.78–1.66) of day 5/6 embryo transfers were higher than those of day 2/3 embryo transfers, but this difference was not significant. The mean cycles per live birth and mean days per live birth in the day 5/6 group were significantly lower than those in the day 2/3 group. This study demonstrated that day 5/6 embryo transfer is a more cost-effective and time-efficient policy than day 2/3 embryo transfer to produce a live baby.
关键词： blastocyst embryo transfer cumulative pregnancy rate cumulative live birth rate IVF
标题 作者 时间 类型 操作
Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with
Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin
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